Nephrotic Syndrome in Malignant Disease of Non-Renal Origin

Loughridge, Lavinia W.; Lewis, Martin

doi:10.1016/s0140-6736(71)90999-8

Cited by 97 publications

(25 citation statements)

References 15 publications

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“…The nephrotic syndrome in association with cancer has been widely reported [25,26] and the lesions described include minimal lesion [25] extra membranous glomerulopathy [25,26], membrano-proliferative glomerulo nephritis [25,26] and focal glomerulonephritis [26]. However, to our knowl edge, extracapillary glomerulonephritis has not previously been reported in association with malignancy.…”

Section: Aetiological Featuresmentioning

confidence: 80%

The Significance of Extracapillary Proliferation

Whitworth

Morel-Marogér

Mignon

et al. 1976

Nephron

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Renal biopsy and clinical data from 60 patients with extracapillary proliferation (crescent formation) in > 50% of glomeruli were correlated. Nephropathy was related to infection (15 cases) malignancy (4 cases) and trichlorethylene exposure (2 cases). Isolated proteinuria was found 0.5–20 years before biopsy in 16 patients. Outcome was significantly related to percentage of crescentic involvement. Oligoanuria and impaired function at presentation were bad prognostic signs but preceding infection was favourable. Diverse histological and immunofluorescent findings indicate that extracapillary glomerulonephritis is not a single entity. The clinical course is not always rapidly progressive.

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Section: Aetiological Featuresmentioning

confidence: 80%

The Significance of Extracapillary Proliferation

Whitworth

Morel-Marogér

Mignon

et al. 1976

Nephron

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“…Several authors [13][14][15][16][17] have reported that MG is fre quently associated with or precedes the onset of carcino mas. For instance in a series described by Eagen and Lewis [18] of 67 patients with carcinomas, 33 had MG.…”

Section: Risks and Benefitsmentioning

confidence: 99%

What Is the Basis for the Use of Steroids in the Treatment of Idiopathic Membranous Nephropathy?

Garattini

Bertani²,

Remuzzi

1987

Nephron

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In the past 30 years steroids have been widely employed in the management of primary glomerulopathies. At variance with ‘minimal-change nephropathy’, in which glucocorticoids are of well-known value, in other forms of immune-mediated glomerulopathies and particularly in idiopathic ‘membranous glomerulopathy’ results of controlled trials are inadequate or controversial. Retrospective analysis of the data reported in the literature indicates a beneficial effect in some series but appears disappointing in others. Certainly the use of high-dose steroids for a prolonged period of time can expose the patients to serious side effects. The aim of the present review is to critically evaluate the results obtained with the use of steroids in the treatment of ‘membranous glomerulopathy’ and reexamine the rationale of their use in the light of the new information on the glucocorticoids mechanism of action on the immune system.

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“…The association of nephrotic syndrome and malignancies is a well-recognized phenomenon (1)(2)(3)(4). However, glomerulopathies associated with lymphoid malignancies are relatively uncommoncompared to carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Nephrotic Syndrome in a Patient with Intravascular Lymphomatosis.

et al. 2003

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The association of malignancy with nephrotic syndrome and renal histopathologic abnormalities is well documented.Wereport a case of intravascular lymphomatosis (IVL) presenting as nephrotic syndrome which was diagnosed by renal biopsy. Histological examination of the renal biopsy specimens showed dissemination of neoplastic lymphoid cells throughout the glomerular capillary bed. These tumor cells were positive for CD20.Since the nephrotic syndromeimprovedwith treatment of the lymphoma, intravascular lymphomatosis may well have played an important role in the pathogenesis of minimal change nephrotic syndrome in this patient. (Internal Medicine 42: 98-101, 2003)

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Nephrotic Syndrome in Malignant Disease of Non-Renal Origin

Cited by 97 publications

References 15 publications

The Significance of Extracapillary Proliferation

The Significance of Extracapillary Proliferation

What Is the Basis for the Use of Steroids in the Treatment of Idiopathic Membranous Nephropathy?

Nephrotic Syndrome in a Patient with Intravascular Lymphomatosis.

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