The Significance of Extracapillary Proliferation

Whitworth, Judith A.; Morel-Marogér, L; Mignon, Françoise; Richet, G

doi:10.1159/000180578

Cited by 93 publications

(13 citation statements)

References 14 publications

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“…Nevertheless, our find ings. like the observations of Whitworth et al [14] and Petzel et al [15] support the idea that crescentic GN can occur as a paraneoplastic syndrome distinct from those renal lesions previously reported to be associated with malignancy.…”

Section: Discussionsupporting

confidence: 77%

“…In contrast, crescentic GN is not usually thought of as a complication of malignancy despite the fact that in a large clinicopathologic study of crescentic GN, 4/60 (7%) of patients had malignancy [14], Our series suggests that 'idiopathic' crescentic GN may indeed be a renal lesion associated with malignancy. 7 of 80 patients with cres centic GN had an associated malignancy.…”

Section: Discussioncontrasting

confidence: 54%

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Crescentic Glomerulonephritis Associated with Nonrenal Malignancies

et al. 1984

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A review of 80 patients with the renal biopsy diagnosis of idiopathic glomerulonephritis with extracapillary proliferation (crescentic GN) disclosed 7 cases with a coexistent nonrenal malignancy; 6 carcinomas and 1 lymphoma. In a control group of 80 patients with the renal biopsy diagnosis of minimal change or focal segmental glomerulosclerosis, only 1 case of coexistent malignancy was found (chi-square = 4.74, p < 0.05). All of the malignancies occurred in patients older than 40 years of age and the prevalence of malignancy in patients with crescentic GN over the age of 40 was 20%. Light microscopy, immunofiuorescence, and electron microscopy revealed fibrin deposition in all cases and no evidence of anti-GBM or immune complex disease. 3 patients experienced a rapidly progressive course while renal function improved in 4 patients following treatment of the underlying malignancy. The pathogenic mechanisms leading to crescentic GN in patients with malignancy are unknown; however, the high prevalence of malignancy in crescentic GN patients older than 40 along with the improvement during the treatment of the underlying malignancy suggests an etiological relationship.

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Section: Discussionsupporting

confidence: 77%

Section: Discussioncontrasting

confidence: 54%

Crescentic Glomerulonephritis Associated with Nonrenal Malignancies

et al. 1984

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“…In our opinion extracapillary lesions, which have frequently been described, also deserve consideration: the relationship between crescentic glomerulonephritis and malignancies and the significance of this relation ship have been recently underlined [28][29][30].…”

Section: Discussionmentioning

confidence: 91%

Nephropathy Associated with Wilms’ Tumor

Gusmano¹,

Perfumo²,

Raspino³

et al. 1987

Nephron

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The association of nephropathy with Wilms’ tumor and male pseudohermaphroditism is known as Drash’s syndrome. The absence of either pseudohermaphroditism or Wilms’ tumor has also been reported. The nephropathy, characterized by proteinuria or nephrotic syndrome, leads rapidly and inevitably to renal failure. The renal findings are those of a chronic glomerulopathy with mesangial hypercellularity, glomerular sclerosis, interstitial infiltration and marked tubular dilation. This infrequent syndrome usually appears in early life, between 1 and 3 years of age. The case of nephropathy associated with Wilms’ tumor we present here is characterized by age and onset: an abrupt onset of renal insufficiency without previous signs of nephropathy in a 13-year-old girl.

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“…The retrospective series of Whitworth et al [2] found 4/60 patients with carcinoma who subsequently manifested crescentic glo merulonephritis, and Biava et al [3] noted 7/81 in their series. Notably, 9 of these cases occurred after the tumour was found, at inter vals up to 3 years.…”

Section: Sim Ultaneous Presentation Of G Astric Carcinom a And Crescementioning

confidence: 94%