Nephrotic Syndrome in Patients With Schistosoma Mansoni Infection *

Pf, Queiroz; Brito, Edilson; Martinelli, Reinaldo; Rocha, Heonir

doi:10.4269/ajtmh.1973.22.622

Cited by 46 publications

(13 citation statements)

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“…In Brazil, mass treatment with oral medications has led to a decrease in the occurrence of the hepatosplenic form of schistosomiasis and a similar impact has been seen on the occurrence of schistosomal glomerulopathy (Correia et al 1997). This change in the frequency of schistosomal glomerulopathy may be reflected in the change in the distribution of glomerular lesions associated with nephrotic syndrome in adults (over 15 years old) that was reported by Queiroz et al (1973Queiroz et al ( ) between 1970Queiroz et al ( -1973 and that we noted in a study conducted between 2003-2006 (Fig. 2).…”

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confidence: 66%

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Schistosomal glomerulopathy and changes in the distribution of histological patterns of glomerular diseases in Bahia, Brazil

dos-Santos¹,

Sweet

Bahiense-Oliveira

et al. 2011

Mem. Inst. Oswaldo Cruz

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confidence: 66%

“…2). Membranoproliferative glomerulonephritis was the most prevalent renal lesion observed in adult patients with nephrotic syndrome in the study by Queiroz et al (1973). In our study, focal segmental glomerulosclerosis was the predominant pattern of disease in this group of patients.…”

supporting

confidence: 62%

Schistosomal glomerulopathy and changes in the distribution of histological patterns of glomerular diseases in Bahia, Brazil

dos-Santos¹,

Sweet

Bahiense-Oliveira

et al. 2011

Mem. Inst. Oswaldo Cruz

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“…The pronounced hypergammaglobulinemia found in humans (16,26,106) and mice (251) and the occurrence of autoantibodies in the latter (134) (8,14). Proteinuria may be linked to HS disease manifestations (177,232). However, glomerulopathy without proteinuria occurs frequently (252) and, when associated with salmonellosis, may be caused by the bacterial rather than the helminthic infection (24 (61,136,230,247).…”

Section: Introductionmentioning

confidence: 99%

Immunopathology of Schistosoma mansoni infection

1989

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Schistosomiasis mansoni is a chronic helminthic disease that affects about 100 million people in the tropics. The worms have a life span of 5 to 10 years, and they live in the mesenteric veins of the host. Lightly infected individuals are asymptomatic or manifest mild intestinal symptoms. Heavily infected individuals often develop severe morbidity with hepatosplenomegaly, sometimes with a fatal outcome. Morbidity is attributed to the strong humoral and T-cell-mediated host immune responses developed to a variety of parasite antigens and expressed as tissue inflammations. The immunopathology includes dermatitis, immune complex-mediated kidney disease, and, chiefly, T-cell-mediated granuloma formation and fibrosis around disseminated parasite eggs. This review describes the mechanisms of induction and expression of immunopathology in infected persons and experimental animals. Immunoregulatory mechanisms that modulate the enhanced immune responses and may ameliorate excessive morbidity are discussed.

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“…Studies from the 1970s demonstrated that membranoproliferative glomerulonephritis was the most prevalent type because of the high prevalence of schistosomiasis and other parasitic diseases. [7][8][9] More recent studies have shown an increase in the incidence of focal and segmental glomerulosclerosis, and this is currently the most prevalent form of glomerulonephritis in Brazil and other regions of the world. [10][11][12] So far, there have been few studies on the distribution of glomerular diseases in the northeastern region of Brazil.…”

Section: Introductionmentioning

confidence: 99%

Pattern, clinical features and response to corticoids of glomerular diseases in a Brazilian population. An analytical cross-sectional study

et al. 2014

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CONTEXT AND OBJECTIVE: Glomerular disease registries are increasing all around the world. The aim of this study was to evaluate the clinical characteristics and treatment response among patients with glomerular diseases followed up in a tertiary hospital in Brazil. DESIGN AND SETTING: Analytical cross-sectional study; tertiary-level public hospital. METHODS:This study included patients with glomerular diseases followed up at a tertiary hospital in Fortaleza, northeastern Brazil. Clinical and laboratory data on each patient were registered. The response to specific treatment was evaluated after 3, 6 and 12 months. RESULTS:The study included 168 patients of mean age 37 ± 14 years. The main clinical presentations were nephrotic proteinuria (67.3%) and renal insufficiency (17.9%). The mean proteinuria value decreased after the treatment began. Regarding 24-hour proteinuria on admission, there was no significant difference between patients with a good response and those with no response (7,448 ± 5,056 versus 6,448 ± 4,251 mg/24 h, P = 0.29). The glomerular disease with the highest remission rate was MCD (92%). Absence of interstitial fibrosis presented a strong correlation with remission (remission in patients without fibrosis = 83.4% versus 16.3% in those with fibrosis, P = 0.001).CONCLUSIONS: The present study found that the most frequent glomerular disease was FSGS, followed by MCD, MN and LN. The presence of interstitial fibrosis was a predictor of poor therapeutic response. Com relação à proteinúria de 24 horas na admissão, não houve diferença significativa entre os pacientes com boa resposta ao tratamento e aqueles sem resposta (7.448 ± 5.056 versus 6.448 ± 4.251 mg/24 h, P = 0,29). A doença com maior índice de remissão foi a DLM (92%). A ausência de fibrose intersticial apresentou forte correlação com a remissão (remissão em pacientes sem fibrose = 83,4% versus 16,3% naqueles com fibrose, P = 0,001). CONCLUSÕES: O presente estudo encontrou como glomerulopatia mais frequente a GESF, seguida da DLM, NM e NL. A presença de fibrose intersticial foi um preditor de pobre resposta terapêutica. RESUMO

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Nephrotic Syndrome in Patients With Schistosoma Mansoni Infection *

Cited by 46 publications

References 0 publications

Schistosomal glomerulopathy and changes in the distribution of histological patterns of glomerular diseases in Bahia, Brazil

Schistosomal glomerulopathy and changes in the distribution of histological patterns of glomerular diseases in Bahia, Brazil

Immunopathology of Schistosoma mansoni infection

Pattern, clinical features and response to corticoids of glomerular diseases in a Brazilian population. An analytical cross-sectional study

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