Nephrotoxic Effects of Chronically Administered Olanzapine and Risperidone in Male Rats

Güleç, Mustafa; Özcan, Halil; Oral, Elif; Dursun, Onur Burak; Ünal, Deniz; Aksak, Selina; Selli, Jale; Keleş, Osman Nuri; Ünal, Bünyamin; Albayrak, Abdulmecit; Halıcı, Zekai

doi:10.5455/bcp.20111208083355

Cited by 10 publications

(6 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly there are rare reports on olanzapine-induced nephrotoxicity as well but with low dose (2.5 mg/kg/d) injected intraperitoneally for 6 weeks, however the dose of 0.5 mg/kg/d has been reported safe (Mustafa et al, 2012). Furthermore, we found mild to moderate focal increase in glomerular cellularity, cellular proliferation and Bowman’s capsules with negligible basement membranes.…”

Section: Discussionmentioning

confidence: 99%

“…Nephrotoxicity with chronic administration (6 weeks) of olanzapine (0.5 and 2.5 mg/kg/d) has been reported with postulation that it was due to oxidative stress (Mustafa et al, 2012). Dietary and pharmacological interventions have been recommended to lessen the APDs-associated alarming events with the suggestion to study the impact of APDs on body weight by gradually escalating the dose (Gohlke et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Olanzapine induced biochemical and histopathological changes after its chronic administration in rats

Shah

Subhan

Ali

et al. 2016

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

Olanzapine is a second generation antipsychotic acting mainly as a dopamine D and serotonine 5-HT receptors antagonist prescribed in the treatment of schizophrenia and various other psychiatric illnesses. Even though olanzapine is widely used in psychiatry, its effects on the architecture of pancreas, liver and kidneys are little known. The histology of pancreas especially has never been studied. For these reasons, the current study was designed to elucidate the toxic effects of chronic administration of olanzapine on pancreas, liver and kidneys and the enzymes released by these tissues in an escalating dose manner. Fourteen male rats were divided into two groups equally, the olanzapine group and the controls. Olanzapine was administered in a dose of 5 mg/kg/d for the first eight weeks, 10 mg/kg/d for next four weeks and 15 mg/kg/d through the last two week period of 14 weeks experiment. The controls received acidified saline only. Both the groups received restricted diet (20 g/12 h). The body weight and level of random blood sugar (RBS) were measured on a weekly basis. The levels of lipase, amylase, alanine transaminase (ALT) and aspartate transaminase (AST) were determined terminally. At the end of the experiment, the tissues were dissected out for histopathological evaluation. Significant loss in body weight, change in the level of random blood sugar ( < 0.05, < 0.001) and significant rise in amylase and lipase levels ( < 0.05, < 0.001) were observed. However, the same treatment has shown no significant change in the levels of alanine and aspartate transaminases ( > 0.05). The pancreas has shown derangement of beta cells and fibrotic growth. A mild to moderate focal increase in glomerular cellularity, cellular proliferation and glomerular capsules with negligible basement membranes were observed in the kidneys. No changes were observed in the architecture of the liver. The findings of this study indicated that the incidence of adverse effects associated with olanzapine could be prevented/alleviated/delayed by allowing restricted diet.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Olanzapine induced biochemical and histopathological changes after its chronic administration in rats

Shah

Subhan

Ali

et al. 2016

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

show abstract

“…A comparable renal toxicity was reported by Abdelmajeed (2009) Gulec et al, (2011) noted that chronically administered olanzapine and risperidone caused nephrotoxic effects in male rats. Olanzapine and risperidone are members of the antipsychotic family and showed significant nephrotoxic effects with losing regularities in both tubular and glomerular structure of kidneys 22 .…”

Section: Discussionmentioning

confidence: 99%

Ameliorative Effect of Broccoli Powder on Renal Toxicity in Mice Caused by Continuous Exposure to Escitalopram Antidepressant Drug

Saxena¹,

Shahani²

2017

Int. Res. J. Pharm.

View full text Add to dashboard Cite

Antidepressants induced metabolic syndrome is a major public health problem in the treatment of psychiatric disorders which leads to an increased risk of cardiovascular disease, non-alcoholic hepatic steatosis and renal dysfunction. Psychiatric disorder is a mental illness that includes depression, schizophrenia, and anxiety disorder that affect millions of people around the world. The purpose of present study was to investigate the protective role of broccoli powder against continuous ingestion of antidepressant drug induced nephrotoxicity in Swiss albino mice. In present study mice were continuously treated with escitalopram antidepressant drug (20 mg/kg/b.w. orally) for 4, 8 and 12 weeks. The escitalopram drug intoxicated group showed elevation in serum urea and creatinine level. Escitalopram drug intoxicated group also showed degeneration of glomerulus and renal tubule that are comparable with carbon tetrachloride (33 mg/kg) group considered as positive control. Group that received both broccoli powder and escitalopram drug (200 mg/kg + 20 mg/kg) significantly reduced elevated level of serum urea and creatinine with mild degeneration of glomerulus and renal tubule as compared to antidepressant drug intoxicated group.

show abstract

“…al. [5] The duct system received little attention although these form important functional component of urogenital system.…”

Section: Introductionmentioning

confidence: 99%

Histopathological and Histomorphometric Studies on the Effects of Olanzapine on Vas Deferens and Urinary Bladder: An Experimental Study in Albino Rats.

Akram

Syed

Faruqi

2019

AANAT

View full text Add to dashboard Cite

Introduction: Olanzapine an atypical anti-psychotic drug is widely used in a number of disorders like schizophrenia and bipolar disorder. Olanzipine shows affinity for a number of muscarinic, dopaminergic and histaminic receptors in the body due to which its effects can be seen on a number of organs in the body. The present study was conducted to see the adverse effects of the drug on the histology of urinary bladder and vas deference as data is not availabe on these organs. Subjects and Methods: Twelve male albino rats divided into equal number of experimental and control groups i.e. 6 rats each. Olanzapine was injected intraperitoneally in experimental rats at a dose of 4mg/kg for 6 weeks daily. Results: Control group received same volume of normal saline, daily, intraperitoneally for the same period. Conclusion: Histopathological and histomorphometric changes conformed degeneration in urinary bladder & vas deferens.

show abstract

Nephrotoxic Effects of Chronically Administered Olanzapine and Risperidone in Male Rats

Cited by 10 publications

References 30 publications

Olanzapine induced biochemical and histopathological changes after its chronic administration in rats

Olanzapine induced biochemical and histopathological changes after its chronic administration in rats

Ameliorative Effect of Broccoli Powder on Renal Toxicity in Mice Caused by Continuous Exposure to Escitalopram Antidepressant Drug

Histopathological and Histomorphometric Studies on the Effects of Olanzapine on Vas Deferens and Urinary Bladder: An Experimental Study in Albino Rats.

Contact Info

Product

Resources

About