Nerve Conduction study in healthy individuals, a preliminary age based study

Thakur, Dilip; Paudel, Bishnu Hari; Jha, Chandra Bhushan

doi:10.3126/kumj.v8i3.6218

Cited by 15 publications

(19 citation statements)

References 17 publications

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“…We expected to see a shorter delay time between stimulus and onset of response in SCD patients because of the autonomic hypersensitivity suggested by sigh‐induced vasoconstriction in SCD patients, and hypersensitivity to pain in sickle mice in direct neuron recordings . However, while this was apparent in the univariable analysis (Supporting Information Table S2), the difference in delay between pain and vasoconstriction in our data was related to participant's age ( P = .01) in the multivariable model, which is consistent with the known slowing of nerve conduction velocity with increasing age …”

Section: Discussionsupporting

confidence: 78%

Individuals with sickle cell disease have a significantly greater vasoconstriction response to thermal pain than controls and have significant vasoconstriction in response to anticipation of pain

et al. 2017

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The painful vaso-occlusive crises (VOC) that characterize sickle cell disease (SCD) progress over hours from the asymptomatic steady-state. SCD patients report that VOC can be triggered by stress, cold exposure and pain itself. We anticipated that pain could cause neural-mediated vasoconstriction, decreasing regional blood flow and promoting entrapment of sickle cells in the microvasculature. Therefore, we measured microvascular blood flow in the fingers of both hands using plethysmography and laser-Doppler flowmetry while applying a series of painful thermal stimuli on the right forearm in 23 SCD patients and 25 controls. Heat pain applied to one arm caused bilateral decrease in microvascular perfusion. The vasoconstriction response started before administration of the thermal pain stimulus in all subjects, suggesting that pain anticipation also causes significant vasoconstriction. The time delay between thermal pain application and global vasoconstriction ranged from 5 to 15.5 seconds and increased with age (p < 0.01). Although subjective measures, pain threshold and pain tolerance were not different between SCD subjects and controls, but the vaso-reactivity index characterizing the microvascular blood flow response to painful stimuli was significantly higher in SCD patients (p = .0028). This global vasoconstriction increases microvascular transit time, and may promote entrapment of sickle cells in the microvasculature, making vaso-occlusion more likely. The rapidity of the global vasoconstriction response indicates a neural origin that may play a part in the transition from steady-state to VOC, and may also contribute to the variability in VOC frequency observed in SCD patients.

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Section: Discussionsupporting

confidence: 78%

Individuals with sickle cell disease have a significantly greater vasoconstriction response to thermal pain than controls and have significant vasoconstriction in response to anticipation of pain

et al. 2017

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“…Without adjustment for age, the sensitivity and specificity of nerve conduction study will decrease when using the same reference data in patients with different age. 12 Interestingly we also noted that the voltage of electrical stimulus needed to record a threshold action potential was found to increase with advancing age. In group III an electrical stimulus of 40-50 mV was needed in comparison to group I who needed 15-25 mV.…”

Section: Discussionmentioning

confidence: 71%

A study on median nerve conduction velocity in different age groups

2015

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“…Without adjustment for age, the sensitivity and specificity of NCS will decrease when using the same reference data in patients with different age. [16] There are many crosssectional studies that have estimated the reduction in NCV ranging between 0.13 m/sec and 0.22 m/sec [17] these also point to the fact that aging has a definite effect on the NC parameters. Cai and Zhang [18] reported in their study that the conduction velocity in a newborn is approximately 50% of adult values and progressively increase, reaching the adult value at the age of three.…”

Section: Discussionmentioning

confidence: 99%

Influence of age, height, gender on median and ulnar nerve conduction study

R¹,

Kannan²,

Patil³

2017

Natl J Physiol Pharm Pharmacol

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Background: Nerve conduction studies (NCSs) is a test to measure the electrical activity in the nerve and used to measure nerve function disease progression. Physiological factors such as age, temperature, height, and gender are known to affect the nerve conduction velocity (NCV). Studies have reported different results with regard to these physiological factors affecting NCS. Aims and Objectives: To examine the influence of age, height, and gender on median and ulnar NCS. Materials and Methods: 103 healthy individuals of both sexes in the age group of 15-65 were included in the study. The neurophysiological study consisted of motor and sensory NCS of the ulnar nerve and median nerve using RMS EMG MKII equipment. Results: The correlation of age on the conduction velocities of median and ulnar nerve showed a significant negative correlation which suggests that as age advances the conduction velocity decreases. The correlation of height on the median and ulnar nerves did not show statistical significance. The influence of gender was analyzed using student t-test, in which the conduction velocities of median motor (P = 0.007), ulnar motor (P = 0.01), and sensory (P = 0.05) were faster in females compared to males. Conclusion: Age and gender have a significant role in influencing the nerve conduction parameters. We could not determine a definite relation of height and NCV. The present study adds substantial evidence that adjusting the nerve conduction parameters for physiological factors such as age and gender and will increase the diagnostic sensitivity and lays emphasis that an electrodiagnostic data should be created considering these variables.

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Nerve Conduction study in healthy individuals, a preliminary age based study

Abstract: Background

Cited by 15 publications

References 17 publications

Individuals with sickle cell disease have a significantly greater vasoconstriction response to thermal pain than controls and have significant vasoconstriction in response to anticipation of pain

Individuals with sickle cell disease have a significantly greater vasoconstriction response to thermal pain than controls and have significant vasoconstriction in response to anticipation of pain

A study on median nerve conduction velocity in different age groups

Influence of age, height, gender on median and ulnar nerve conduction study

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