Nerve conduction velocity studies of workers employed in the manufacture of phenoxy herbicides

Singer, Raymond; Moses, Marion; Valciukas, José A.; Lilis, Ruth; Selikoff, Irving J.

doi:10.1016/0013-9351(82)90032-9

Cited by 42 publications

(15 citation statements)

References 31 publications

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“…These non-pesticide ingredients may have contributed to the observed associations between HPEEs and measures of neurobehavioral function independently of the specific active pesticide ingredient. Furthermore, although recent studies of neurological outcomes among pesticide-exposed workers have focused on organophosphate pesticide exposure, many other pesticides have some neurotoxic potency as well (Reuber 1983; Singer et al 1982; Keim and Alavanja 2001; Kamel and Hoppin, 2004; Costa et al 2008). In the present study, pesticide-specific information was available for only the most recently reported HPEE at the time of each AHS interview and little or no additional information was available about the formulation of the involved pesticide.…”

Section: Discussionmentioning

confidence: 99%

High pesticide exposure events and central nervous system function among pesticide applicators in the Agricultural Health Study

Starks

Gerr

Kamel

et al. 2011

Int Arch Occup Environ Health

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Purpose While acute pesticide poisoning can be associated with persistent adverse central nervous system (CNS) effects, little is known about the effect of episodic and unusually high pesticide exposure events (HPEEs) that typically do not result in acute poisoning. The objective of this investigation was to examine the association between HPEEs and CNS function among licensed pesticide applicators enrolled in the Agricultural Health Study (AHS). Methods In 2006–2008, 693 male participants, with no history of a physician-diagnosed pesticide poisoning, completed nine neurobehavioral tests to assess memory, motor speed, sustained attention, verbal learning, and visual scanning and processing. Information on HPEEs and pesticide poisonings was obtained from previous AHS interviews. Associations between HPEEs and neurobehavioral outcomes were estimated with linear regression controlling for age and outcome-specific covariates. Results A history of at least one HPEE was reported by 156 (23%) participants. Adverse associations were observed between HPEEs and two of the nine neurobehavioral tests. On a test of visual scanning and processing (Digit-Symbol), participants with HPEEs were 4.2 seconds slower (95% CI: −7.27, −1.11) than those without HPEEs, equivalent to the effect of 3.9 years of age in this population. On a test of visual scanning and motor speed (Sequences A), participants with HPEEs were 2.5 seconds slower (95% CI: −4.53, −0.41) than those without HPEEs, equivalent to the effect of 3.9 years of age. No significant associations were observed between HPEEs and the other neurobehavioral tests. Conclusions HPEEs may contribute to adverse CNS outcomes independent of diagnosed pesticide poisoning.

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Section: Discussionmentioning

confidence: 99%

High pesticide exposure events and central nervous system function among pesticide applicators in the Agricultural Health Study

Starks

Gerr

Kamel

et al. 2011

Int Arch Occup Environ Health

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“…Furthermore, slowing of NCV by arsenic (Blom et al, 1985), carbon disulfide (Hirata et al, 1984), acrylamide (Fullerton, 1969), herbicides (2,4-D) (Singer et al, 1982) and triorthocresyl phosphate (Janz and Neundorfer, 1968) has been reported.…”

Section: Application In Occupational Andmentioning

confidence: 96%

Neurophysiological Methods in Occupational and Environmental Health: Methodology and Recent Findings

Araki

Yokoyama

Murata

1997

Environmental Research

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“…Die exponierten Arbeiter wiesen mit zunehmender Beschäftigungsdauer signifikant verminderte Leitungsgeschwindigkeiten auf (Singer et al 1982). Die exponierten Arbeiter wiesen mit zunehmender Beschäftigungsdauer signifikant verminderte Leitungsgeschwindigkeiten auf (Singer et al 1982).…”

Section: Neurologische Wirkungunclassified

2,4‐Dichlorphenoxyessigsäure (2,4‐D) einschl. Salze und Ester [MAK Value Documentation in German language, 1994]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 20. Lieferung, Ausgabe 1994 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik Erfahrungen beim Menschen Akute Toxizität Wirkungen bei wiederholter Exposition Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Sonstige Wirkungen Tierexperimentelle Befunde und in‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Sonstige Wirkungen Bewertung

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Nerve conduction velocity studies of workers employed in the manufacture of phenoxy herbicides

Cited by 42 publications

References 31 publications

High pesticide exposure events and central nervous system function among pesticide applicators in the Agricultural Health Study

High pesticide exposure events and central nervous system function among pesticide applicators in the Agricultural Health Study

Neurophysiological Methods in Occupational and Environmental Health: Methodology and Recent Findings

2,4‐Dichlorphenoxyessigsäure (2,4‐D) einschl. Salze und Ester [MAK Value Documentation in German language, 1994]

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