Nerve fibers TGF-β1 (transforming growth factor beta1) expression is related to dysmenorrhea and the laparoscopic appearance of endometriotic implants

Innervation of endometrium and myometrium in women with painful adenomyosis and uterine fibroids

“…Peritoneal and deeply infiltrating endometriotic lesions showed SP-positive nerve fibers (34,45). Nerve growth factor and neutrophin-3 were expressed in endometriotic plaques, and NGF specific tyrosine-kinase receptor (Trk-A), transforming growth factor (TGF-b1), and growth-associated protein 43 were expressed in endometriosis-associated nerve fibers (4,45,47). Activated mast cells and degranulating mast cells were present in endometriotic lesions (5).…”

A pilot study to evaluate the clinical relevance of endometriosis-associated nerve fibers in peritoneal endometriotic lesions

“…However, the fundamental pathological mechanism underlying endometriosis-related pain seems to be unclear, particularly the role of peritoneal lesions in generating pelvic pain (19,20). Important data on innervation of endometriosis, endometrium, and myometrium have been delivered by different groups of investigators.…”

Growth-associated protein 43–positive sensory nerve fibers accompanied by immature vessels are located in or near peritoneal endometriotic lesions

“…The fundamental pathological mechanism underlying endometriosis-associated pain still remains unclear, particularly the role of peritoneal lesions in generating pelvic pain (21,22).…”