Nerve growth factor level in the prostatic fluid of patients with chronic prostatitis/chronic pelvic pain syndrome is correlated with symptom severity and response to treatment

Watanabe, Toyohiko; Inoue, Miayabi; Sasaki, Kenji; Araki, Motoo; Uehara, Shuichiro; Monden, Koichi; Sakaguchi, Takashi; Nasu, Yasutomo; Kumon, Hiromi; Chancellor, Michael B.

doi:10.1111/j.1464-410x.2010.09716.x

Cited by 59 publications

(55 citation statements)

References 20 publications

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“…Several recent publications reported other biomarkers of CP. Watanabe et al [20] reported research from 20 cases, which revealed that nerve growth factor levels were significantly elevated in EPS from men with CPPS (NIH-III prostatitis) compared to controls. Wei et al [21] reported that the levels of B7-H3 were significantly lower in EPS from men with CPPS compared to controls.…”

Section: Discussionmentioning

confidence: 99%

Clinical Evaluation of Urine Prostatic Exosomal Protein in the Diagnosis of Chronic Prostatitis

Li¹,

Jiang²,

Liu³

et al. 2017

Urol Int

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Objective: To evaluate the clinical potential of urine prostatic exosomal protein (PSEP) as a diagnostic biomarker of chronic prostatitis (CP). Materials andmethods: Using an enzyme-linked immunosorbent assay kit, urine PSEP levels were detected in 103 control cases as well as 283 cases of CP, with 82 cases fulfilling the definition of the USA National Institutes of Health category II (NIH-II), 108 cases of NIH-IIIa and 93 cases of NIH-IIIb. The values of age, body mass index, prostate volume, serum prostatic specific antigen (PSA) urine PSEP levels, and seminal parameters were analyzed. Results: The PSEP levels were significantly higher in patients of NIH-II (2.09 [2.35] ng/mL), NIH-IIIa (1.80 [2.95] ng/mL) and NIH-IIIb (1.64 [2.48] ng/mL) compared to the value of 0.24 (0.76) ng/mL in the controls. ROC identified a cutoff value of 1.387 ng/mL, with a sensitivity of 59.0% and specificity of 94.2%. The area under the ROC curve was 0.833. PSEP levels positively correlated with serum PSA levels in the NIH-IIIb group, and with EPS WBC count in the NIH-IIIa group, and with semen WBC count in each CP subgroups but negatively correlated with sperm motility in both the NIH-IIIa group and the NIH-IIIb group. Conclusion: Urine PSEP could be a potential biomarker for CP.

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Section: Discussionmentioning

confidence: 99%

Clinical Evaluation of Urine Prostatic Exosomal Protein in the Diagnosis of Chronic Prostatitis

Li¹,

Jiang²,

Liu³

et al. 2017

Urol Int

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“…To reduce the number of white blood cells in CNP rats, down regulate the expression of NF-κB, iNOS, ICAM-1, TNF-α, and inhibit the inflammatory reaction Turmeric [ 13] curcumin After intraperitoneal injection of curcumin in rats, the levels of IL-1β, TNF-α, MCP-1 and MIP-1α were reduced, and the peripheral nerves were repaired.…”

Section: Tripterygium Wilfordii Polyglycosidementioning

confidence: 99%

Modern Analysis of Traditional Chinese Medicine for Chronic Abacterial Prostatitis

Liu¹,

Tan²,

Li³

et al. 2017

Proceedings of the 2nd International Conference on Biomedical and Biological Engineering 2017 (BBE 2017)

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Abstract. Objective: To explore the therapeutic principles of modern Chinese medicine for chronic prostatitis and the application of TCM in CNP. Procedures and Methods: Analysised the relevant information and literature, to explore the mechanism of Chinese medicine for the treatment of prostatitis, sum up TCM and Chinese patent medicine of treatment prostatitis, Put forward ideas for the development of TCM treat CNP. Results: Various active ingredients of TCM played a role in reducing fever and causing diuresis and other effects, to achieve anti-infection, improve microcirculation, regulate the role of prostatic fluid PH value, significant efficacy in the treatment of CNP is safe and reliable, with little side effect. Conclusion:To summarize TCM on CNP of the exact curative effect and active ingredients, to provide more scientific and accurate basis for the TCM treatment of prostatitis, to develop new drugs for treatment of prostatitis and to promote Chinese medicine to the world. Related Study on Prostatitis of Chinese and Western Medicine Western Medicine for Chronic Non-Bacterial Prostatitis in Modern ResearchThe incidence of prostatitis for outpatient department of Urology in more common, accounting for about 20% to 25%, divided into bacterial and non bacterial type, according to the microscope prostate massage fluid, semen, terminal urine routine results, chronic non-bacterial prostate (CP / CNP) is divided into inflammatory and noninflammatory, The clinical manifestations of urgent urinationfrequent urination, urinary obstruction, perineal, testicular and lumbosacral tingling or pain and body age increasing, decreased resistance, reduce the secretion of male hormones and other reasons will aggravate the disease, causing obstruction, stones and other complications, seriously affect the quality of life of patients. Because of the special physiological structure of the pathogenic causes and pathological changes is not clear, prostatic epithelial lipid membrane is a variety of antibiotics into the acinar barrier, the clinical treatment by depending on experience, which lead to poor efficacy of prostatitis.Western medicine in the treatment of CNP mainly through the inhibition of neurotransmitter release, smooth muscle relaxation, improve the patients with depression and anxiety to alleviate pain, sedation, improve urine flow rate, improve voiding symptoms, alleviate perineal pain, antidepression etc.. Commonly used drugs are: non steroidal anti-inflammatory drugs; αblockers, 5αreductase inhibitors; anti spasm analgesic (such as Gaba Martin), tricyclic antidepressants; antibiotics, etc.. However, due to the lack of understanding of the etiology and pathology of Western medicine, often lead to poor efficacy or poor compliance of patients. 57This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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“…Researchers in Japan recently analyzed NGF levels expressed in the prostatic fluid of 20 patients with CP/CPPS before and after single, varied, 8-week treatment trials. These were compared to the NGF levels found in 4 asymptomatic control patients [28]. Before initiating treatment, men with CP/CPPS were found to have elevated NGF as measured by enzyme-linked immunosorbent assay; however, the difference between patients and control patients was not significant.…”

Section: Nervous Systemmentioning

confidence: 99%

Proposed New Pathophysiology of Chronic Prostatitis/Chronic Pelvic Pain Syndrome

Cho

Min

2015

Urogenit Tract Infect

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The most common type of prostatitis is category III, also known as chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). The current National Institutes of Health definition of CP/CPPS includes genitourinary pain with or without voiding symptoms in the absence of uropathogenic bacteria, as detected by standard microbiological methods, or other identifiable causes such as malignancy. Many different etiologies and mechanisms of pathogenesis of CP/CPPS have been proposed with a suggested role for immunological, neurological, endocrine, and psychological factors. We examined the data supporting the role of each of these areas and also examined the possible interrelationship of these factors in producing the symptoms of CP/CPPS. Prostatitis types IIIa and IIIb are classified according to the presence of pain without concurrent presence of bacteria; however, it is becoming more evident that, although levels of bacteria are not directly associated with levels of pain, the presence of bacteria might act as the initiating factor that drives primary activation of mast-cell-mediated inflammation in the prostate. The gate control theory provides a neurologic basis for the influence of both somatic and psychological factors on pain. Acceptance of chronic pain as a diagnosis may be difficult for the clinician and patient, however it is an important concept in the care of CP/CPPS, which enables the use of pain-directed therapies. Management of CP/CPPS will remain challenging; however, this review provides a better understanding of the condition and improved management strategies based on the newest evidence and concepts available. Keywords: Prostatitis; Chronic pain; Physiopathology INTRODUCTIONChronic prostatitis/chronic pelvic pain syndrome (CP/ CPPS) is a condition of chronic pelvic pain in men [1]. It has been estimated that between 2% and 14% of men worldwide may have symptoms of CP/CPPS [2,3]. The diagnosis is made on the basis of symptoms of pain with or without voiding symptoms in the absence of other identifiable causes [4]. The etiology of symptoms in a given patient can be from many causes. Whether there are identifiable, repeatable patterns of causes of symptoms, or just individual patients with distinct individual phenotypes are unknown. Because CP/CPPS is a common condition associated with significant physical, mental, and social burden, the medical community has made tremendous efforts to understand the condition and improve management strategies. Despite these efforts, answers remain elusive. Robust tools to measure symptom severity Our improved understanding of the etiology and clinical phenotypes associated with CP/CPPS has made the condition less of a clinical enigma. Acceptance of clinical definitions (and classification system) and validated, reliable outcome questionnaire (the CP symptom index) has led to high-quality treatment evidenced from randomized placebo-controlled trials. This article is a very timely review of the topic and provides the clinician with an improved understanding of CP/CPPS a...

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Nerve growth factor level in the prostatic fluid of patients with chronic prostatitis/chronic pelvic pain syndrome is correlated with symptom severity and response to treatment

Cited by 59 publications

References 20 publications

Clinical Evaluation of Urine Prostatic Exosomal Protein in the Diagnosis of Chronic Prostatitis

Clinical Evaluation of Urine Prostatic Exosomal Protein in the Diagnosis of Chronic Prostatitis

Modern Analysis of Traditional Chinese Medicine for Chronic Abacterial Prostatitis

Proposed New Pathophysiology of Chronic Prostatitis/Chronic Pelvic Pain Syndrome

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