Nervione, a new benzofuran derivative from <i>Nervilia concolor</i>

Tran, Cong-Luan; Tri, Mai Dinh; Tien-Trung, Nguyen; Phan, Nhat-Minh; Phan, Cam-Tu Dang; Tran, Thanh-Nha; Do, Thanh-Hung; Tran, Nguyen‐Minh‐An; Tran, Thi-Ngoc-Mai; Duong, Thuc‐Huy

doi:10.1080/14786419.2021.1920585

Cited by 4 publications

References 28 publications

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Antioxidant, Cytotoxic, Anti‐Glycation, and Anti‐Tyrosinase Compounds from the Leaves of Uvaria Siamensis

Wongwad,

Jadsadajerm,

Mungmai

et al. 2024

Chemistry & Biodiversity

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A new oxidized heptene, 7‐benzoyloxy‐4‐hydroxy‐1‐ethoxy‐2E,4Z‐heptadiene‐1,6‐dione, namely siamheptene A (1), together with eight known compounds (2–9), were isolated from the leaves of Uvaria siamensis. Their structures were identified by detailed analysis of spectroscopic (IR, 1D and 2D NMR) and mass spectrometric data. Compound 9 is reported for the first time from Uvaria genus. Siamheptene A was evaluated for cytotoxicity against HeLa (cervical cancer cells), A549 (lung cancer cells), and Vero cells using the MTT assay and screened for antibacterial activities. In addition, isolated compounds (1–7, and 9) were investigated for their antioxidant (DPPH, FRAP and ABTS assays), anti‐glycation, and anti‐tyrosinase properties. Based on our results,compound 1 had mild cytotoxicity against Hela and A549 cancer cell lines, with IC50 ranging from 31.09 to 31.67 μg/mL. Compound 1 also showed antioxidant activities in all tasted assays. However, it showed no detectable activity (> 128 μg/mL) against various bacterial strains, and it has no inhibitory effects on tyrosinase enzymes. Among of all tested compounds, chrysin (5), showcased highest anti‐glycation and anti‐tyrosinase activities. This comprehensive analysis provides highlighting the potential of 1 as a lead compound for further structural modification and development of cytotoxic or antioxidant agents.

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Antioxidant, Cytotoxic, Anti‐Glycation, and Anti‐Tyrosinase Compounds from the Leaves of Uvaria Siamensis

Wongwad,

Jadsadajerm,

Mungmai

et al. 2024

Chemistry & Biodiversity

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Proteomics-based network pharmacology and molecular docking reveal the potential mechanisms of 5,6,7,4′-tetramethoxyflavone against HeLa cancer cells

You,

Li,

Ding

et al. 2024

Heliyon

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Recurvataside, a new saponin from aerial parts of Mussaenda recurvata

Tri

Tram

Ngoc

et al. 2022

Natural Product Research

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A new glycoside, recurvataside (1) and six known compounds, quinovic acid (2), quinovic acid 28-O-β-D-glucopyranosyl ester (3), 3-O-β-D-glucopyranosylquinovic acid (4), 3-O-β-Dglucopyranosylquinovic acid 28-O-β-D-glucopyranosyl ester (5), pomolic acid (6), and ursolic acid (7) were isolated from aerial parts of Mussaenda recurvata. The structure of compound 1 was identified from its spectroscopic data and by comparison with the literature.Recurvataside represents the first occurrence of δ-oleanolic acid saponin bearing two Dglucose units at C-3 and C-28 in nature. This is the first time δ-oleanane-type saponin reported in the genus Mussaenda. Compounds 1-7 were evaluated the cytotoxicity against two cancer cell lines MCF-7 and HepG2. Among them, only compound 7 exhibited moderate activity against MCF-7 and HepG2 cell lines with IC 50 value of 16.97 ± 1.55 and 20.28 ± 1.00 μM, respectively. Compounds 1-7 were also tested for their inhibitory NO production in LPS-stimulated RAW264.7 cells. Compounds 3, 5, and 7 showed significant reduction of nitrite accumulation in LPS-stimulated RAW 264.7 cells with the IC 50 values of 8. 81 ± 0.48, 13.42 ± 0.84, and 18.37 ± 0.67 μM, respectively

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Nervione, a new benzofuran derivative from Nervilia concolor

Cited by 4 publications

References 28 publications

Antioxidant, Cytotoxic, Anti‐Glycation, and Anti‐Tyrosinase Compounds from the Leaves of Uvaria Siamensis

Antioxidant, Cytotoxic, Anti‐Glycation, and Anti‐Tyrosinase Compounds from the Leaves of Uvaria Siamensis

Proteomics-based network pharmacology and molecular docking reveal the potential mechanisms of 5,6,7,4′-tetramethoxyflavone against HeLa cancer cells

Recurvataside, a new saponin from aerial parts of Mussaenda recurvata

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