Nesfatin-1 alleviates gastric damage via direct antioxidant mechanisms

Kolgazi, Meltem; Cantali-Ozturk, Cigdem; Deniz, Rabia; Ozdemir-Kumral, Zarife Nigar; Yüksel, Meral; Şirvancı, Serap; Yeğen, Berrak Ç.

doi:10.1016/j.jss.2014.06.057

Cited by 58 publications

(59 citation statements)

References 32 publications

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“…18 Furthermore, Kolgazi et al reported that nesfatin-1 alleviates gastric damage via antioxidant mechanisms. 17 So consistent with these reports, in the present study we first demonstrated that nesfatin-1 pretreatment significantly ameliorated serum SCr, BUN and histopathologic damage by attenuate oxidative stress and apoptotic cell death.…”

Section: Discussionsupporting

confidence: 92%

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The protective effect of nesfatin-1 against renal ischemia–reperfusion injury in rats

Jiang

Wang

et al. 2015

Renal Failure

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(2015) The protective effect of nesfatin-1 against renal ischemia-reperfusion injury in rats, Renal Failure, 37:5,[882][883][884][885][886][887][888][889] LABORATORY STUDYThe protective effect of nesfatin-1 against renal ischemia-reperfusion injury in rats Guanjun Jiang, Min Wang, Lei Wang, Hui Chen, Zhiyuan Chen, Jia Guo, Xiaodong Weng, and Xiuheng Liu Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei, PR China Abstract Introduction: The pathogenetic mechanisms underlying ischemia-reperfusion (I/R) injury involve oxidative stress, inflammation and apoptosis. Nesfatin-1, a novel peptide, has been reported to possess antioxidant, anti-inflammatory and anti-apoptic properties. The study was to examine the potential protective effects of nesfatin-1 on renal I/R injury. Materials and methods: I/R model was induced by placing a clamp across left renal artery for 45 min followed by 24 h reperfusion, along with a contralateral nephrectom. Twenty-four rats divided into three groups: sham-operated group, vehicle-treated I/R and nesfatin-1-treated I/R. Nesfatin-1 was intraperitoneally injected 30 min before renal ischemia. We harvested serum and kidneys at 24 h after reperfusion. Renal function and histological changes were assessed. Marker of oxidative stress and cells in kidney were also evaluated. Results: The animals with nesfatin-1 significantly improved renal functional and histologic lesions induced by I/R injury. The malondialdehyde (MDA) level decreased, whereas superoxide dismutase (SOD) and catalase (CAT) activities were significantly increased. Moreover, nesfatin-1-treated rats had a markedly decrease in apoptotic tubular cells, as well as a decrease in caspase-3 activity and an increase in the bcl-2/Bax ratio. Conclusions: This is the first evidence that nesfatin-1 treatment ameliorates acute renal I/R injury by suppressing oxidative stress and cell apoptosis. Therefore, it is promising as a potential therapeutic agent for renal IR injury.

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Section: Discussionsupporting

confidence: 92%

“…15,16 Recently, it has also reported that nesfatin-1 possessed antioxidant, anti-inflammatory and anti-apoptotic properties, and protects the heart against I/R injury. [17][18][19] However, to the best of our knowledge, there have been no articles to report the protective effects of nesfatin-1 against renal I/R injury.…”

Section: Introductionmentioning

confidence: 99%

The protective effect of nesfatin-1 against renal ischemia–reperfusion injury in rats

Jiang

Wang

et al. 2015

Renal Failure

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“…This finding is in line with other investigators who concluded that, Nesfatin-1 can be protective for intestinal and renal ischemia reperfusion injury by inhibiting the generation of pro-inflammatory mediators [21] . Also, Nesfatin-1 can alleviate gastric inflammatory damage induced by indomethacin [21] .…”

Section: C-reactive Protein (Crp)supporting

confidence: 93%

“…Furthermore, Nesfatin-1 significantly decreased CRP level in post conditioning group (group III), indicating that Nesfatin-1 has anti inflammatory property which is protective against cardiac I/R. This finding is in line with other investigators who concluded that, Nesfatin-1 can be protective for intestinal and renal ischemia reperfusion injury by inhibiting the generation of pro-inflammatory mediators [21] . Also, Nesfatin-1 can alleviate gastric inflammatory damage induced by indomethacin [21] .…”

Section: C-reactive Protein (Crp)supporting

confidence: 87%

“…Moreover, it is possible to say that oxidative and inflammatory response activation are extremely important in ischemia-reperfusion (MI/R)injury phenomenon [18] . It is worth saying that Nesfatin-1 could serve a neuro and gastroprotective function by supporting the balance in oxidant and antioxidant systems and by affecting inflammatory profile [19,20,21] ,So the reduced expression of Nesfatin-1 may play a role in the pathogenesis of MI/R injury [19,20] . Moreover, administration of exogenous Nesfatin-1 may play a cardioprotective effect in those patients.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Nesfatin-1 on Ischaemia-Reperfusion Injury in Isolated Heart of Albino Rats

Tawfik

Al-Aleem

Ibrahim

et al. 2016

Zagazig University Medical Journal

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Background: Nesfatin-1 is a hypothalamic neuropeptide which is involved in control of food intake and glucose homeostasis. Lower plasma level of Nesfatin-1 in patients with acute myocardial infarction (AMI) was reported. Objective: This study was designed to explore possible effect of Nesfatin-1 on ischemia-reperfusion injury in isolated heart of adult male albino rats and to explain the possible involved mechanisms, in a trial to clarify Nesfatin-1 expected cardioprotective effect. Design: This study was carried out on eighteen adult male albino rats which were divided equally (n=6) into 3 groups: Group I (ischemia-reperfusion I/R group); hearts were stabilized then subjected to (I/R) protocol, Group II (Nesfatin-1 preconditioning group); Nesfatin-1 was infused for 20 minutes before hearts were subjected to ischemia and Group III (Nesfatin-1 post-conditioning group); Nesfatin-1 was infused for 20 minutes at the beginning of 120 minutes of reperfusion. Cardiac performance indicators as left ventricular pressure (LVP), +max (LV dp/dt), -max (LVdP/dt)+, in addition to heart rate were recorded. Lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB), superoxide dismutase (SOD) and C-reactive protein (CRP) were measured in the collected perfusate and cardiac Malondialdehyde (MDA) was measured. Finally, Nitro blue tetrazolium stain was used to detect the necrotic tissue percentage to the whole left ventricular mass. Results: In group III (post conditioning group), there was a significant increase of the studied cardiac parameters compared to group I (I/R). Nesfatin-1 significantly increased LVP, +max (dp/dt), -max (dp/dt) and HR in comparison with I/R group. This was associated with a significant decrease in LDH and CK-MB levels, a significant increase in SOD level and a significant decrease in MDA and CRP levels. Moreover, Nesfatin-1 caused a significant decrease in percentage of necrotic tissue to the whole left ventricular mass. Regarding group II, no significant changes were detected in all parameters except for significant increase in SOD level and significant decrease in CRP level. Conclusion: Nesfatin-1 protects against ischemia/reperfusion injury in vitro through its antioxidant and anti-inflammatory properties by limiting the infarction area, only if given as a post conditioning factor after I/R. Those results open the way to include Nesfatin-1 among the strategies for management of cardiac infarction during reperfusion.

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Atractylodes Processing Products Protect against Gastric Ulcers in Rats by Influencing the NF‐κB‐MMP‐9/TIMP‐1 Regulatory Mechanism and Intestinal Flora

Zeng

Shen

Fan

et al. 2023

Chemistry & Biodiversity

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Atractylodes macrocephala Koidz. (AM) is a Chinese herbal medicine that is widely used for treating gastrointestinal diseases. However, little research has focused on it as a single medicine for treating gastric ulcers. Honey‐bran stir‐frying is a characteristic method of concocting AM, so we speculated that AM is more effective after this preparation process. Analysis by ultra‐high‐performance liquid chromatography‐hybrid quadrupole‐Orbitrap high‐resolution mass spectrometry revealed changes in the chemical composition of raw Atractylodes (SG), bran‐fried Atractylodes (FG), and honey‐bran‐fried Atractylodes (MFG). MFG was superior to SG and FG in improving the pathological structure of gastric tissue in rats with acute gastric ulcers, reducing inflammatory cell infiltration in gastric tissue, and significantly reducing malondialdehyde while increasing superoxide dismutase and glutathione peroxidase, and reducing the damage caused by free radical accumulation in the gastric mucosa. In addition, MFG reduced the expression of matrix metalloproteinase‐9 (MMP‐9), an inhibitor of metalloproteinase‐1 (TIMP‐1) and nuclear factor kappa‐B (NF‐κB)proteins, inhibited inflammatory response, and regulated the degradation and rebalancing of the extracellular matrix. Fecal microbiota analysis also revealed that MFG normalized the intestinal flora to some extent. Our study shows that AM had a protective effect on rats with alcohol‐induced acute gastric ulcers before and after processing, and AM‐processed products were more effective than raw ones. Compared with MF, MFG had a higher rate of ulcer inhibition and a stronger anti‐inflammatory effect, and its mechanism of action was related to the NF‐κB‐MMP‐9/TIMP‐1 signaling pathway.

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Nesfatin-1 alleviates gastric damage via direct antioxidant mechanisms

Cited by 58 publications

References 32 publications

The protective effect of nesfatin-1 against renal ischemia–reperfusion injury in rats

The protective effect of nesfatin-1 against renal ischemia–reperfusion injury in rats

Effect of Nesfatin-1 on Ischaemia-Reperfusion Injury in Isolated Heart of Albino Rats

Atractylodes Processing Products Protect against Gastric Ulcers in Rats by Influencing the NF‐κB‐MMP‐9/TIMP‐1 Regulatory Mechanism and Intestinal Flora

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