Nesfatin-1 and Vitamin D levels may be associated with systolic and diastolic blood pressure values and hearth rate in polycystic ovary syndrome

Şahin, Figen Kır; Şahin, Serap Baydur; Ural, Ülkü Mete; Cüre, Medine Cumhur; Şentürk, Senem; Tekın, Yeşim Bayoğlu; Balık, Gülşah; Yüce, Süleyman; Kırbaş, Aynur

doi:10.17305/bjbms.2015.432

Cited by 26 publications

(30 citation statements)

References 37 publications

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“…Their results were similar to those reported by Tan et al (28) who compared the levels of Nesfatin-1 in 38 adult subjects. Sahin et al (29) found higher levels of Nesfatin-1 in polycystic ovary syndrome than healthy controls and also reported that these values positively correlated with SBP and DBP. In our study, the Nesfatin-1 levels in both groups were between the commercial kit normal values.…”

Section: Discussionmentioning

confidence: 92%

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Can Nesfatin-1 Predict Hypertension in Obese Children?

Güneş¹,

Baylan²,

Güneş³

et al. 2020

Jcrpe

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Objective: The prevalence of childhood obesity is increasing and leads to co-morbidities such as hypertension. However, it is still not clear why some obese individuals are hypertensive and others not. Nesfatin-1 is a recently discovered anorexigenic peptide which also has effects on blood pressure (BP). Our aim was to evaluate the relationship between obesity-related hypertension and Nesfatin-1. Methods: This cross-sectional study comprised 87 obese children. The patients were divided into two groups; hypertensive (n=30) and normotensive (n=57) obese. The American Academy of Pediatrics guidelines were used to diagnose hypertension. Blood samples were collected after 12 hours of fasting to investigate Nesfatin-1 concentrations. We also evaluated serum trace elements in addition to the routine blood tests. Results: Body mass index (BMI), weight and serum Nesfatin-1 concentrations were higher in the hypertensive group (p=0.002, p=0.001, and p=0.007, respectively). There was no difference between serum zinc levels, but Copper (Cu) levels were significantly lower in the hypertensive group (p=0.248, p=0.007, respectively). There were positive correlations between BP and BMI and weight Z-scores and a negative correlation with Cu. The optimal cut-off value of Nesfatin-1 to predict hypertension was found to be >1.8 ng/mL, with a specificity of 71.9% and a sensitivity of 96.7% [area under the curve=0.703, 95% confidence interval (CI): 0.577-0.809; p=0.002]. In multiple logistic regression analysis Nesfatin-1 [Odds ratio (OR)=1.103, 95% CI: 1.039-1.171; p=0.001], Cu (OR=0.947, 95% CI: 0.915-0.979; p=0.001) and BMI for age Z-score (OR=56.277, 95% CI: 5.791-546.907; p=0.001) still remained significant predictors of hypertension. Conclusion: Nesfatin-1 levels are higher and are an independent predictor of hypertension in obese subjects.(2), and is over 10% in some studies (3). This increased prevalence also poses a more serious problem by increasing the incidence of obesity-related co-morbid conditions. In addition to metabolic diseases such as diabetes and insulin resistance, obese patients are prone to various cardiovascular diseases such as hypertension and dyslipidemia. This increased disease burden, starting from childhood, deserves Abstract 29 What is already known on this topic? What this study adds?Childhood obesity is increasing over the years and leads to morbidities such as hypertension.Obesity causes hypertension but the reason/s why all obese individuals are not hypertensive is controversial. This study aimed to clarify part of this issue by comparing obese peers stratified by blood pressure and found that Nesfatin-1 independently predicts hypertension in obese children.

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Section: Discussionmentioning

confidence: 92%

“…In our study Nesfatin-1 was independently associated with hypertension and was predictive of hypertension in obese subjects. Zhao et al (23) and Sahin et al (29) found a positive correlation between Nesfatin-1 level and BP. However we did not find significant correlation between Nesfatin-1 and BP.…”

Section: Discussionmentioning

confidence: 96%

Can Nesfatin-1 Predict Hypertension in Obese Children?

Güneş¹,

Baylan²,

Güneş³

et al. 2020

Jcrpe

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“…Dai et al showed that lower nesfatin-1 concentration may have an important role in the development of acute myocardial infarction (17). Sahin et al reported that Nesfatin-1 levels play an important role in the pathogenesis of hypertension in patients with polycystic ovary syndrome (18). Angelone et al demonstrated that Nesfatin-1 elicits an incisive influence on the heart by depressing contractility and relaxation (23).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies showed that there is an association between serum nesfatin-1 concentrations and development and severity of peripheral arterial disease (16), acute myocardial infarction (17), and hypertension (18). However, it was not studied yet the effects of functional gene variations of NUCB2/Nesfatin-1 gene on CAD risk.…”

Section: Introductionmentioning

confidence: 99%

Rs214101 Variation of NUCB2/Nesfatin-1 Gene: Effects on Metabolic Parameters Independent of Type 2 Diabetes or Obesity in Coronary Artery Disease

et al. 2017

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Nesfatin-1 (NUCB2) gene, was introduced as a novel satiety factor involves in the control of energy homeostasis in the hypothalamus. Since NUCB2/nesfatin-1 has an effect on diabetes and obesity, it is a candidate gene that can be responsible for causing coronary artery disease (CAD).Therefore, we aimed to identify the association between rs214101 (C/T) SNP of NUCB2 gene and the possible amplified effects of this genetic variation together on the development risk of CAD in this study.This study was carried out in 110 patients with CAD, and 69 CAD-free controls. The NUCB2/nesfatin-1 rs214101 genotypes were analysed by PCR-RFLP technique. The CC genotype frequency of the NUCB2 rs214101 was greater in control group than CAD group (34.8% vs.52.7%; P = 0,019).The CC-genotype was associated with low serum HDL-C level compared to T allele in female CAD subgroup (P = 0.031), but, not in males. Unlike the CAD group, it was observed that the male control subjects carrying CC genotype have higher serum HDL-cholesterol and diastolic blood pressure levels than those with T allele (P = 0.043 and P = 0.031, respectively) but, not in females. Logistic regression analysis confirmed that the NUCB2/Nesfatin-1 rs214101 CC-genotype is associated with low serum HDL-cholesterol in female CAD patients. Our results suggest that the CC genotype of NUCB2 rs214101 may contribute to susceptibility CAD risk in relation to low HDL-C and that the genetic effect could differ by gender.

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“…Wysoki poziom krążącej nesfatyny-1 jest związany ze wzrostem skurczowego i rozkurczowego ciśnienia krwi oraz rytmu serca (ryc. 1) (80). Biorąc pod uwagę fakt, iż tkanka tłuszczowa jest źródłem nesfatyny-1, a wielkość sekrecji jest związana z dietą (78), nesfatyna-1 może odgrywać istotną rolę w oddziaływaniu otyłości na rozwój chorób układu sercowo-naczyniowego (25).…”

Section: Nesfatyna-1 a Otyłośćunclassified

Nesfatin-1: Pleiotropic hormone

Tymicki¹,

Puzio²,

Pawłowska-Olszewska³

2020

Medycyna Weterynaryjna

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Nesfatin-1 was first identified in 2006 as an anorexigenic peptide involved in appetite regulation. It is expressed both in the central nervous system and in the peripheral tissues. The anatomical location of neurons expressing nesfatin-1 and its co-occurrence with other neurotransmitters in the CNS indicate that its physiological role involves not only the regulation of food intake, but also neuroendocrine regulation and autonomic control of internal organs and behavioral responses. It affects the functions of the digestive tract and the cardiovascular system and plays an important role in the regulation of water intake, sleep, and reproductive functions. It plays an important role in the mechanism of metabolic control of the body, regulation of energy balance and body temperature, and development of obesity. Nevertheless, both the main source of nesfatin-1 in the circulation and the exact mechanisms of its functioning are not fully understood. Considering the pleiotropic effect of nesfatin-1, the relationship between the degree of body fatness and the risk of various diseases and the increase in the expression of nesfatin-1 in adipocytes with the development of obesity, it can be assumed that in the near future it will be taken into account as an important factor in the development, and perhaps treatment, of various diseases.

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Nesfatin-1 and Vitamin D levels may be associated with systolic and diastolic blood pressure values and hearth rate in polycystic ovary syndrome

Cited by 26 publications

References 37 publications

Can Nesfatin-1 Predict Hypertension in Obese Children?

Can Nesfatin-1 Predict Hypertension in Obese Children?

Rs214101 Variation of NUCB2/Nesfatin-1 Gene: Effects on Metabolic Parameters Independent of Type 2 Diabetes or Obesity in Coronary Artery Disease

Nesfatin-1: Pleiotropic hormone

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