Nesfatin-1 improves oxidative skin injury in normoglycemic or hyperglycemic rats

Solmaz, Ali; Gülçiçek, Osman Bilgin; Yiğitbaş, Hakan; Çelik, Atilla; Karagöz, Ayça; Özsavcı, Derya; Şirvancı, Serap; Yeğen, Berrak Ç.

doi:10.1016/j.peptides.2015.12.006

Cited by 24 publications

(22 citation statements)

References 53 publications

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“…Nesfatin-1 inhibited the expression of IL-1β in rats. 20 Inflammatory genes such as NF-κB, TNFα, IL-1β, and IL-6 were significantly suppressed by nesfatin-1 treatment. 7 The rats undergoing subarachnoid hemorrhage showed increased levels of TNFα, IL-1β, and IL-6 in brain.…”

Section: Discussionmentioning

confidence: 94%

“…9 Nesfatin-1 is highly expressed in human and rodent beta cells. 20 Nesfatin-1 is likely to alleviate DR via an anti-angiogenic role. 10 In addition, NUCB2 was positively correlated with insulin gene expression and insulin secreting capacity.…”

Section: Discussionmentioning

confidence: 99%

“…Recent study reported that nesfatin-1 improves oxidative skin injury in rats through suppressing vascular endothelial growth factor in the epidermal keratinocytes. 20 Nesfatin-1 is likely to alleviate DR via an anti-angiogenic role.…”

Section: Discussionmentioning

confidence: 99%

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Relation of serum and vitreous nesfatin-1 concentrations with diabetic retinopathy

et al. 2017

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

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Relation of serum and vitreous nesfatin-1 concentrations with diabetic retinopathy

et al. 2017

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“…extrahypothalamic tissues such as gastrointestinal tissue (gastric oxyntic mucosa, pancreatic beta cells, and liver), skeletal muscle, and adipose tissue [25][26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Nesfatin-1 alleviates extrahepatic cholestatic damage of liver in rats

Solmaz

Gülçiçek

Erçetin

et al. 2016

Bosn J of Basic Med Sci

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Obstructive jaundice (OJ) can be defined as cessation of bile flow into the small intestine due to benign or malignant changes. Nesfatin-1, recently discovered anorexigenic peptide derived from nucleobindin-2 in hypothalamic nuclei, was shown to have anti-inflammatory and antiapoptotic effects. This study is aimed to investigate the therapeutic effects of nesfatin-1 on OJ in rats. Twenty-four adult male Wistar-Hannover rats were randomly assigned to three groups: sham (n = 8), control (n = 8), and nesfatin (n = 8). After bile duct ligation, the study groups were treated with saline or nesfatin-1, for 10 days. Afterward, blood and liver tissue samples were obtained for biochemical analyses, measurement of cytokines, determination of the oxidative DNA damage, DNA fragmentation, and histopathologic analyses. Alanine aminotransferase and gamma-glutamyl transferase levels were decreased after the nesfatin treatment; however, these drops were statistically non-significant compared to control group (p = 0.345, p = 0.114). Malondialdehyde levels decreased significantly in nesfatin group compared to control group (p = 0.032). Decreases in interleukin-6 and tumor necrosis factor-α levels from the liver tissue samples were not statistically significant in nesfatin group compared to control group. The level of oxidative DNA damage was lower in nesfatin group, however this result was not statistically significant (p = 0.75). DNA fragmentation results of all groups were similar. Histopathological examination revealed that there was less neutrophil infiltration, edema, bile duct proliferation, hepatocyte necrosis, basement membrane damage, and parenchymal necrosis in nesfatin compared to control group. The nesfatin-1 treatment could alleviate cholestatic liver damage caused by OJ due to its anti-inflammatory and antioxidant effects.

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“…Nesfatin‐1 injection contributed to the reduced expression of nuclear factor kappa‐B, and reduced levels of TNF‐α, IL‐1β, and IL‐6 in rat traumatic brain tissues [6]. Solmaz reported that nesfatin‐1 treatment depressed skin IL‐1β levels in non‐diabetic or diabetic rats with surgical wounds [14]. Additionally, increased plasma levels of proinflammatory cytokines including TNF‐α, IL‐1β, and IL‐6, were depressed by nesfatin‐1 treatment in rats with subarachnoid hemorrhage [15].…”

Section: Discussionmentioning

confidence: 99%

Association of serum nesfatin‐1 concentrations with atrial fibrillation

Duan

2018

The Kaohsiung J of Med Scie

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Nesfatin‐1, a newly discovered adipokine, inhibits inflammatory response. Inflammation is involved in the mechanism of atrial fibrillation (AF). We aim to determine the association between serum nesfatin‐1 concentrations and AF. A population of 200 patients with AF and 108 patients without AF were enrolled in this study. These patients were divided into three subgroups of paroxysmal AF, persistent AF, and permanent AF. Serum nesfatin‐1 concentrations were lower in AF patients than in controls. Logistic regression analysis showed that serum nesfatin‐1 concentrations were inversely associated with AF. Serum nesfatin‐1 concentrations in permanent AF patients decreased compared with those in persistent and paroxysmal AF groups. In addition, persistent AF patients showed reduced serum nesfatin‐1 concentrations compared with paroxysmal AF subjects. Serum nesfatin‐1 concentrations were negatively correlated with left atrial diameter. In conclusion, serum nesfatin‐1 concentrations were inversely correlated with AF development.

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Nesfatin-1 improves oxidative skin injury in normoglycemic or hyperglycemic rats

Cited by 24 publications

References 53 publications

Relation of serum and vitreous nesfatin-1 concentrations with diabetic retinopathy

Relation of serum and vitreous nesfatin-1 concentrations with diabetic retinopathy

Nesfatin-1 alleviates extrahepatic cholestatic damage of liver in rats

Association of serum nesfatin‐1 concentrations with atrial fibrillation

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