Relation of serum and vitreous nesfatin-1 concentrations with diabetic retinopathy

Dai, Rongfeng; Deng, Guohua; Sun, Zhuo; Liu, Zhinan; Qian, Yu; Yan, Han

doi:10.1002/jcla.22105

Cited by 12 publications

(13 citation statements)

References 22 publications

(30 reference statements)

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“…Li et al first investigated the fasting plasma levels of nesfatin-1 in type 2 diabetes patients and found that fasting nesfatin-1 levels were significantly lower in the type 2 diabetes group compared with the levels in healthy subjects [ 12 ]. Several subsequent studies also reached the same conclusion [ 10 , 11 , 13 , 14 ]. However, Zhang et al reached the opposite conclusion [ 9 ].…”

Section: Discussionsupporting

confidence: 61%

“…These results showed no evidence of heterogeneity and explained part of the heterogeneity problem of the full analysis. As four studies from the antidiabetic treatment subgroup were located in China [ 11 – 14 ], we next performed pooled analysis, and the result was similar to that for the antidiabetic treatment subgroup [ Figure 2(c) , MD = −0.27; 95% CI (−0.34 and −0.20), P < 0.00001, I 2 = 0%].…”

Section: Resultsmentioning

confidence: 84%

“…Six studies were in English [ 8 – 13 ] and one was Chinese [ 14 ]. Three studies were cross-sectional studies [ 9 – 11 ] and four were case-control studies [ 8 , 12 – 14 ]. The diagnosis of type 2 diabetes was based on the criteria from the American Diabetes Association (ADA) in three studies [ 10 – 12 ] and the World Health Organization (WHO) in four studies [ 8 , 9 , 13 , 14 ].…”

Section: Resultsmentioning

confidence: 99%

“…Circulating nesfatin-1 levels in all included studies were examined after overnight fasting. Blood samples were obtained from the serum in three studies [ 10 , 11 , 14 ] and from plasma in four studies [ 8 , 9 , 12 , 13 ] and were all measured by enzyme-linked immunosorbent assay (ELISA). The group size ranged from 20 to 74 in the included studies.…”

Section: Resultsmentioning

confidence: 99%

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Circulating Nesfatin-1 Levels and Type 2 Diabetes: A Systematic Review and Meta-Analysis

Zhai

Fan

et al. 2017

Journal of Diabetes Research

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The role of nesfatin-1 in glucose homeostasis has been investigated previously. However, although numerous studies have examined the relationships between circulating nesfatin-1 levels and type 2 diabetes, the conclusions are contradictory. We aimed to probe the relationship between circulating nesfatin-1 levels and type 2 diabetes by meta-analysis. Seven studies including 328 type 2 diabetes patients and 294 control subjects were included. Although there was no obvious difference in circulating nesfatin-1 levels between patients with type 2 diabetes and the control group (MD = −0.04; 95% CI = −0.32 to −0.23), subgroup analysis showed higher nesfatin-1 levels in newly diagnosed type 2 diabetes patients (MD = 0.59; 95% CI = 0.45 to 0.74) and significantly lower nesfatin-1 levels in type 2 diabetes patients receiving antidiabetic treatment (MD = −0.26; 95% CI = −0.33 to −0.20). In conclusion, the analysis supports a relationship between circulating nesfatin-1 levels and type 2 diabetes, where newly diagnosed type 2 diabetes was associated with an elevated Nesfatin-1 level, and type 2 diabetes patients receiving antidiabetic treatment showed lower circulating nesfatin-1 levels.

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Section: Discussionsupporting

confidence: 61%

Section: Resultsmentioning

confidence: 84%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Circulating Nesfatin-1 Levels and Type 2 Diabetes: A Systematic Review and Meta-Analysis

Zhai

Fan

et al. 2017

Journal of Diabetes Research

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“…Similarly, mRNA and protein expression is significantly reduced in the islets of Goto-Kakizaki (GK) rats, a model of type 2 diabetes (8). It has also been shown that fasting plasma nesfatin-1 levels are significantly reduced in T2DM (15)(16)(17), whereas plasma nesfatin-1 in type 1 diabetic patients was unchanged compared with healthy individuals (17). Accordingly, the concentrations of nesfatin-1 in the serum and milk of gestational diabetic lactating women is lower than that of control participants (18).…”

Section: Introductionmentioning

confidence: 99%

NUCB2 polymorphisms are associated with an increased risk for type 2 diabetes in the Chinese population

Li¹,

Yan²,

Fan³

et al. 2020

Ann Transl Med

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Background: The nucleobindin 2 (NUCB2) gene encodes the NUCB2 protein, which plays a critical role in glucose metabolism and diabetes. This study explored the correlation between NUCB2 genetic variants and type 2 diabetes mellitus (T2DM). The study further examined the different NUCB2 variants that confer risk to T2DM in Chinese Han populations. Methods: This study evaluated the anthropometric and glycemic profiles of 578 T2DM patients and 1,609 healthy controls. Subsequently, we genotyped five single nucleotide polymorphisms (SNPs) (rs10832756, rs1330, rs10766383, rs10832757, and rs11024251) in all the study participants using a Sequenom Mass ARRAY SNP genotyping platform. Results: The distribution of polymorphisms was significantly different between the T2DM patients and healthy controls. Our logistic regression analysis results showed that the five NUCB2 SNPs are significantly correlated with the risk for T2DM, especially rs11024251(P=2.97×10 −6). Interestingly, analysis of male and female sub-populations separately showed that only two of the SNPs (rs10832757 and rs11024251) have significant correlation to T2DM in males [P=0.0244, odds ratio (OR) 1.28 and P=0.0062, OR 1.35, respectively). In females however, we identified four significant SNPs (rs1330, rs10766383, rs10832757, and rs11024251; P<0.05, OR 1.31-1.42). Furthermore, we found that rs1330 is associated with body mass index of female subpopulation only (P=0.0174, β =0.0060). Conclusions: NUCB2 polymorphisms could have a pivotal role in the presence of T2DM. Sex-specific SNPs of NUCB2 could account for the differences in clinical features of T2DM between male and female subpopulations. Nevertheless, our results should be replicated using larger sample sizes, and experimental investigations are needed to elucidate the molecular mechanisms of the associations observed in this study.

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Islet β-cell-produced NUCB2/nesfatin-1 maintains insulin secretion and glycemia along with suppressing UCP-2 in β-cells

et al. 2019

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Nesfatin-1 is a hypothalamic anorexigenic peptide processed from nucleobindin 2 (NUCB2). Central and peripheral administration of NUCB2/nesfatin-1 enhances glucose metabolism and insulin release. NUCB2/nesfatin-1 is also localized in pancreatic islets, while its function remains unknown. To explore the role of pancreatic β-cell-produced NUCB2/nesfatin-1, we developed pancreatic β-cell-specific NUCB2 knockout (βNUCB2 KO) mice and NUCB2 gene knockdown (shNUCB2) MIN6 β-cell line. In βNUCB2 KO mice, casual blood glucose was elevated from 12 weeks of age. In a glucose tolerance test at 12 weeks, insulin secretion at 15 min was reduced and blood glucose at 2 h increased in βNUCB2 KO mice fasted 8 h. In islets isolated from βNUCB2 KO mice, high glucose-stimulated insulin secretion (GSIS) was impaired. In shNUCB2 MIN6 cells, GSIS was reduced and UCP-2 mRNA expression was elevated. These results show impaired GSIS possibly associated with UCP-2 overexpression in NUCB2-silenced β-cells, suggesting that β-cell-produced NUCB2/nesfatin-1 maintains GSIS and thereby glycemia.

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Relation of serum and vitreous nesfatin-1 concentrations with diabetic retinopathy

Abstract: Serum and vitreous nesfatin-1 concentrations were negatively correlated with DR.

Cited by 12 publications

References 22 publications

Circulating Nesfatin-1 Levels and Type 2 Diabetes: A Systematic Review and Meta-Analysis

Circulating Nesfatin-1 Levels and Type 2 Diabetes: A Systematic Review and Meta-Analysis

NUCB2 polymorphisms are associated with an increased risk for type 2 diabetes in the Chinese population

Islet β-cell-produced NUCB2/nesfatin-1 maintains insulin secretion and glycemia along with suppressing UCP-2 in β-cells

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