Nesiritide for Pulmonary Arterial Hypertension With Decompensated Cor Pulmonale

Abstract

Pulmonary arterial hypertension complicated by decompensated cor pulmonale is a challenging clinical problem with few effective therapeutic options. B-type natriuretic peptide is a pluripotent hormone that promotes diuresis and natriuresis, vasodilates systemic and pulmonary vessels, and reduces circulating levels of endothelin and aldosterone. It may represent a possible therapeutic strategy for decompensated cor pulmonale in the same manner that it is used to treat decompensated left heart failure. The authors report their experience with B-type natriuretic peptide as adjunctive therapy for pulmonary arterial hypertension complicated by decompensated cor pulmonale. A detailed case report is presented followed by the evaluation of a series of 11 cases occurring in eight patients from December 2002 through April 2004.

γ-Tocopherol Accelerated Sodium Excretion in a Dose-Dependent Manner in Rats with a High Sodium Intake

“…Natriuretic hormone is an effective vasodilator and induces diuretic. As a pharmacological treatment, the hormone improves hypertension and inhibits the development of cardiac failure [ 5 , 6 ]. The γ-tocopherol (γ-Toc) urinary metabolite, 2,7,8-trimethyl-2-(2'-carboxyethyl)-6-hydroxychroman (γ-CEHC), plays a role similar to natriuretic hormones [ 7 – 9 ] (Fig.…”