Nestin in the Temporal Neocortex of the Intractable Epilepsy Patients

Wang, Liang; Wang, Xuefeng; Yuan, Jie; Xi, Zhiqin; Xue, Tao; Li, Yuqin; Xiao, Zheng

doi:10.1007/s11064-008-9824-4

Cited by 10 publications

(12 citation statements)

References 23 publications

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“…Most nestin‐positive cells in epileptic patients show an astrocyte‐like form with characteristic sharp multipolar processes 12,13 . It is considered that nestin‐positive cells may be derived from astrocytes or neural precursor cells and play a role in the reconstruction of glia 14,15 …”

Section: Introductionmentioning

confidence: 99%

An immunohistochemical finding in glioneuronal lesions associated with epilepsy: The appearance of nestin‐positive, CD34‐positive and tau‐accumulating cells

Nagaishi¹,

Arai²,

Osawa

et al. 2011

Neuropathology

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Several kinds of unusual cells have been pathologically identified in epileptic patients. CD34-positive, nestin-positive and tau-positive cells are some of them. However, no reports have investigated the significance of these cells. We examined 14 cases of seizure-associated glioneuronal lesions to investigate the incidences and distributions of these cells and the association between their incidence and clinical parameters. CD34-positive and nestin-positive cells were seen in 43% and 50% of cases, respectively. In the regions with structural anomalies, there were increased numbers of CD34-positive cells and nestin-positive cells, but they were identified as different cells. Both examinations showed many abnormal processes in oligodendroglial-like cells with round nuclei. In contrast, few reactive astrocytes that demonstrated immunoreactivity for glial fibrillary acidic protein were found in this area. Tau accumulation was present in 37% of cases. There was no correspondence with the regions showing increasing numbers of nestin or CD34-positive cells. There were no significant associations between epileptic clinical parameters and the incidences of the abovementioned immunopositive cells. CD34-positive cells and nestin-positive cells are found as frequently as balloon cells and are associated with abnormal reconstitution of the cortex. These findings support the assertion that increases in the numbers of these cells might contribute to promoting epilepsy. In addition, these immunopositive cells are valuable findings for the pathological identification of epileptogenic lesions.

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Section: Introductionmentioning

confidence: 99%

An immunohistochemical finding in glioneuronal lesions associated with epilepsy: The appearance of nestin‐positive, CD34‐positive and tau‐accumulating cells

Nagaishi¹,

Arai²,

Osawa

et al. 2011

Neuropathology

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“…Neuron loss was a predominant pathological change in the epileptogenic zones; the present study demonstrated this pathological change. After seizures, neuronal survival and neurogenesis were also observed in the brain tissue of patients [2]. Up-regulation of IR after seizures might participate in the regulation of neuronal loss and neuronal survival, which are both consequences that can be induced by seizures.…”

Section: Discussionmentioning

confidence: 97%

“…Immunostaining was performed on the paraffin sections as reported previously [2]. Counterstaining was done using Harris hematoxylin.…”

Section: Immunohistochemistry and Double-label Immunofluorescencementioning

confidence: 99%

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Increased insulin receptor expression in anterior temporal neocortex of patients with intractable epilepsy

Wang

Liu

et al. 2010

Journal of the Neurological Sciences

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“…There has been found some abnormal expression of proteins such as nestin, aquaporin-1, slit-2, and TGF-β1 that appear under pathological injuries such as seizure. Therefore, altered astrocytes disturb the interneural and astrocyte-neuron interaction, promoting the development of RE [16–18]. …”

Section: The Pathomechanism Of Refractory Epilepsymentioning

confidence: 99%

State of the art paper Deep brain stimulation for refractory epilepsy

Tykocki¹,

Mandat²,

Kornakiewicz³

et al. 2012

aoms

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Deep brain stimulation (DBS) is a method of treatment utilized to control medically refractory epilepsy (RE). Patients with medically refractory epilepsy who do not achieve satisfactory control of seizures with pharmacological treatment or surgical resection of the epileptic focus and those who do not qualify for surgery could benefit from DBS. The most frequently used stereotactic targets for DBS are the anterior thalamic nucleus, subthalamic nucleus, central-medial thalamic nucleus, hippocampus, amygdala and cerebellum. The DBS is believed to be an effective method of treatment for various types of epilepsy among adults and adolescents. Side effects may be associated with implantation of electrodes and with the stimulation itself. An increasing number of publications and growing interest in DBS application for RE may result in standardization of the qualification and treatment protocol for RE with DBS.

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Nestin in the Temporal Neocortex of the Intractable Epilepsy Patients

Cited by 10 publications

References 23 publications

An immunohistochemical finding in glioneuronal lesions associated with epilepsy: The appearance of nestin‐positive, CD34‐positive and tau‐accumulating cells

An immunohistochemical finding in glioneuronal lesions associated with epilepsy: The appearance of nestin‐positive, CD34‐positive and tau‐accumulating cells

Increased insulin receptor expression in anterior temporal neocortex of patients with intractable epilepsy

State of the art paper Deep brain stimulation for refractory epilepsy

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