Network analysis of single-subject fMRI during a finger opposition task

Smith, Jason F.; Chen, Kewei; Johnson, Sterling C.; Morrone-Strupinsky, Jeannine V.; Reiman, Eric M.; Nelson, Ann E.; Moeller, James R.; Alexander, Gene E.

doi:10.1016/j.neuroimage.2005.12.010

Cited by 34 publications

(27 citation statements)

References 33 publications

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“…We found a mean Euclidean distance of 9.1± 0.8 mm between the thumb and index finger, compared with 9.61±2.27 mm previously reported (Lotze et al 2000). Our "finger disparity" for control individuals was 5.7 to 9.1 mm from the group average, compared with previous reports of 8.14±1.69 (Smith et al 2006). The consistency between studies suggests that our musicians' finger representations were not expanded, as might have been expected from studies that showed enlarged representations in skilled musicians (Meister et al 2005;Pantev et al 2001;PascualLeone et al 1995).…”

Section: Control Subjects: Finger Representationscontrasting

confidence: 60%

Altered Finger Representations in Sensorimotor Cortex of Musicians with Focal Dystonia: Precentral Cortex

Burman

Lie-Nemeth

Brandfonbrener

et al. 2008

Brain Imaging and Behavior

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Using functional magnetic resonance imaging (fMRI), finger representations were characterized in the precentral cortex of 11 normal musicians and 14 musicians with focal task-specific dystonia. Finger representations were identified from differential activation during repetitive movements of each finger relative to others. Despite group similarities in topography, abnormalities in representations of affected fingers were identified. For the finger showing chronic flexion (primary dystonic finger or PDF), the cortical "disparity" from its normal location and the distance to the adjacent finger were increased. By contrast, representational characteristics of the finger showing chronic extension (primary compensatory finger or PCF) did not differ significantly from the control group, but did differ from those of the PDF. Regardless of whether either finger's representation differed substantively from normal, the PCF consistently showed greater volume of activation than the PDF or other fingers. These findings reflect dysfunctional interactions between at least two fingers and their cortical representations.

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Section: Control Subjects: Finger Representationscontrasting

confidence: 60%

Altered Finger Representations in Sensorimotor Cortex of Musicians with Focal Dystonia: Precentral Cortex

Burman

Lie-Nemeth

Brandfonbrener

et al. 2008

Brain Imaging and Behavior

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show abstract

“…Multivariate network analyses, such as the scaled subprofile model (SSM) (Moeller et al, 1987), test for regional interactions that can reflect the distributed effects of aging or disease and associated alterations in functional or anatomical connectivity. The SSM has been applied in numerous human functional neuroimaging studies (Alexander and Moeller, 1994;Moeller and Eidelberg, 1997;Alexander et al, 1999;Habeck et al, 2003;Smith et al, 2006). Previous studies of healthy human aging using SSM analysis with structural MRI VBM identified age-related gray matter patterns that included reductions in dorsolateral prefrontal and temporal regions Brickman et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Age-Related Regional Network of Magnetic Resonance Imaging Gray Matter in the Rhesus Macaque

Alexander¹,

Chen²,

Aschenbrenner³

et al. 2008

J. Neurosci.

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Human structural neuroimaging studies have supported the preferential effects of healthy aging on frontal cortex, but reductions in other brain regions have also been observed. We investigated the regional network pattern of gray matter using magnetic resonance imaging (MRI) in young adult and old rhesus macaques (RMs) to evaluate age effects throughout the brain in a nonhuman primate model of healthy aging in which the full complement of Alzheimer's disease (AD) pathology does not occur. Volumetric T1 MRI scans were spatially normalized and segmented for gray matter using statistical parametric mapping (SPM2) voxel-based morphometry. Multivariate network analysis using the scaled subprofile model identified a linear combination of two gray matter patterns that distinguished the young from old RMs. The combined pattern included reductions in bilateral dorsolateral and ventrolateral prefrontal and orbitofrontal and superior temporal sulcal regions with areas of relative preservation in vicinities of the cerebellum, globus pallidus, visual cortex, and parietal cortex in old compared with young RMs. Higher expression of this age-related gray matter pattern was associated with poorer performance in working memory. In the RM model of healthy aging, the major regionally distributed effects of advanced age on the brain involve reductions in prefrontal regions and in the vicinity of the superior temporal sulcus. The age-related differences in gray matter reflect the effects of healthy aging that cannot be attributed to AD pathology, providing support for the targeted effects of aging on the integrity of frontal lobe regions and selective temporal lobe areas and their associated cognitive functions.

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“…[23][24][25][26][27]). Among others, cortical motor areas include primary (sensori-) motor cortex (SM1) along the central sulcus, supplementary motor areas (SMA) located on the medial surface on the frontal lobes and premotor areas located laterally on the frontal lobes anterior to SM1.…”

Section: Introductionmentioning

confidence: 99%

A serial functional connectivity MRI study in healthy individuals assessing the variability of connectivity measures: reduced interhemispheric connectivity in the motor network during continuous performance

Amann¹,

Hirsch²,

Gass³

2009

Magnetic Resonance Imaging

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Network analysis of single-subject fMRI during a finger opposition task

Cited by 34 publications

References 33 publications

Altered Finger Representations in Sensorimotor Cortex of Musicians with Focal Dystonia: Precentral Cortex

Altered Finger Representations in Sensorimotor Cortex of Musicians with Focal Dystonia: Precentral Cortex

Age-Related Regional Network of Magnetic Resonance Imaging Gray Matter in the Rhesus Macaque

A serial functional connectivity MRI study in healthy individuals assessing the variability of connectivity measures: reduced interhemispheric connectivity in the motor network during continuous performance

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