Network-based cancer precision medicine: A new emerging paradigm

Tan, Aidi; Huang, Huiya; Zhang, Peng; Li, Shao

doi:10.1016/j.canlet.2019.05.015

Cited by 31 publications

(20 citation statements)

References 106 publications

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“…In recent years, there has been increasing concern about the application of bioinformatics and systems biology approaches to understand the development of diseases and the mechanism of the TCMs ( Li and Zhang, 2013 ; Zheng et al, 2018 ; Tan et al, 2019 ; Wang X. et al, 2020 ). Based on the new trend in interdisciplinary fields, Li et al established TCM systems bioinformatics (TCMSB) and proposed for the first time a map of “Phenotype network-Biological network-Herb network,” which contributes to identifying network biomarkers for TCM syndrome and herb formula ( Li et al, 2007 ; Li, 2009 ).…”

Section: The Classification and Treatment Of Cold And Hot Syndromesmentioning

confidence: 99%

A Song of Ice and Fire: Cold and Hot Properties of Traditional Chinese Medicines

2021

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The theory of cold and hot properties is the basic theory of traditional Chinese medicines (TCMs) and has been successfully applied to combat human diseases for thousands of years. Although the theory of cold and hot is very important to guide the clinical application of TCMs, this ancient theory remains an enigma for a long time. In recent years, more and more researchers have tried to uncover this ancient theory with the help of modern techniques, and the cold and hot properties of a myriad of TCMs have been studied. However, there is no review of cold and hot properties. In this review, we first briefly introduced the basic theories about cold and hot properties, including how to distinguish between the cold and hot properties of TCMs and the classification and treatment of cold and hot syndromes. Then, focusing on the application of cold and hot properties, we take several important TCMs with cold or hot property as examples to summarize their traditional usage, phytochemistry, and pharmacology. In addition, the mechanisms of thermogenesis and antipyretic effect of these important TCMs, which are related to the cold and hot properties, were summarized. At the end of this review, the perspectives on research strategies and research directions of hot and cold properties were also offered.

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Section: The Classification and Treatment Of Cold And Hot Syndromesmentioning

confidence: 99%

A Song of Ice and Fire: Cold and Hot Properties of Traditional Chinese Medicines

2021

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“…NM assumes that all cellular components that belong to the same topological, functional or disease module have a high likelihood of being involved in the same disease. Network-based tools have been applied to a wide range of diseases and pathophenotypes 49,50 , such as several different types of cancer, including prostate cancer (Table 1).…”

Section: Network-based Approaches In Prostate Cancer Researchmentioning

confidence: 99%

Prostate cancer screening research can benefit from network medicine: an emerging awareness

et al. 2020

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Up to date, screening for prostate cancer (PCa) remains one of the most appealing but also a very controversial topics in the urological community. PCa is the second most common cancer in men worldwide and it is universally acknowledged as a complex disease, with a multi-factorial etiology. The pathway of PCa diagnosis has changed dramatically in the last few years, with the multiparametric magnetic resonance (mpMRI) playing a starring role with the introduction of the "MRI Pathway". In this scenario the basic tenet of network medicine (NM) that sees the disease as perturbation of a network of interconnected molecules and pathways, seems to fit perfectly with the challenges that PCa early detection must face to advance towards a more reliable technique. Integration of tests on body fluids, tissue samples, grading/staging classification, physiological parameters, MR multiparametric imaging and molecular profiling technologies must be integrated in a broader vision of "disease" and its complexity with a focus on early signs. PCa screening research can greatly benefit from NM vision since it provides a sound interpretation of data and a common language, facilitating exchange of ideas between clinicians and data analysts for exploring new research pathways in a rational, highly reliable, and reproducible way.

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“…Furthermore, text mining was applied to gather the ingredients in plasma after oral administration of JDNW formula. The ten different herbs, PU, RR, PN, LH, HMM, VAH, TKM, ALRP, CR and RS contributed 6,3,7,8,18,7,14,11,3 and 57 active ingredients, respectively. In total, 114 unduplicated active ingredients were identi ed.…”

Section: Identi Cation Of Active Ingredientsmentioning

confidence: 99%

“…Network-based strategies hold great promise in supporting such transition from the "single-gene-based" paradigm to a "network-based" paradigm for drug discovery in many diseases, such as cancer [7], rheumatoid arthritis [8] and coronary heart disease [9]. Network pharmacology is also successfully applied in discovering biological mechanisms of Chinese medicine on liver diseases including liver brosis [10], non-alcoholic liver disease [11] and drug-induced liver injury [12].…”

Section: Introductionmentioning

confidence: 99%

Uncovering bioactive compounds and potential mechanisms of Jieduan-Niwan Formula against liver failure

Ma¹,

Zhang²,

Gao³

et al. 2020

Preprint

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Background Liver failure is considered as the inability of the liver to perform its normal synthetic and metabolic function. Our previous data showed that Jieduan-Niwan formula (JDNW) induced liver failure, while its underlying mechanism remains unknown. Methods In the present study, we performed a network pharmacology to analyze the bioactive ingredients and related targets. Compound and target data of JDNW formula were retrieved from the Traditional Chinese Medicine Systems Pharmacology Database (TCMSP), and targets related to liver diseases were obtained from DisGeNET database. Information of protein protein interaction were retrieved from STRING database. Network construction and degree calculation were used Cytoscape software. Metascape web-server was used for GO and KEGG pathway enrichment. A microarray data series (GSE72081) was obtained from Gene Expression Omnibus database and analyzed using R project and Connectivity Map. Ledock was used for molecular docking. Results A total of 114 unduplicated active ingredients were identified after ADME screening. After construction of a target-liver disease network, 28 targets were identified for anti-liver failure effect. These targets were significantly enriched in fluid shear stress and atherosclerosis, pathways in cancer, IL-17 signaling pathway, HIF-1 signaling pathway, insulin resistance, toxoplasmosis, prostate cancer, microRNAs in cancer, NF-kappa B signaling pathway, Chemical carcinogenesis, VEGF signaling pathway and complement and coagulation cascades pathways. After analyzing a public microarray data of quercetin, we found biological action of some NFκB inhibitors was similar to quercetin. Molecular docking study showed that quercetin possessed a capability to bind on IKKβ and inhibited NFκB activation. Conclusions JDNW formula treated liver failure via multiple targets and multiple pathways, including NFκB signal. Quercetin was identified as a key bioactive ingredient of JDNW formula and its anti-liver failure effect may involve in NFκB inhibition.

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Network-based cancer precision medicine: A new emerging paradigm

Cited by 31 publications

References 106 publications

A Song of Ice and Fire: Cold and Hot Properties of Traditional Chinese Medicines

A Song of Ice and Fire: Cold and Hot Properties of Traditional Chinese Medicines

Prostate cancer screening research can benefit from network medicine: an emerging awareness

Uncovering bioactive compounds and potential mechanisms of Jieduan-Niwan Formula against liver failure

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