2017
DOI: 10.1111/jnc.13921
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Network‐based characterization of the synaptic proteome reveals that removal of epigenetic regulator Prmt8 restricts proteins associated with synaptic maturation

Abstract: The brain adapts to dynamic environmental conditions by altering its epigenetic state, thereby influencing neuronal transcriptional programs. An example of an epigenetic modification is protein methylation, catalyzed by protein arginine methyltransferases (PRMT). One member, Prmt8, is selectively expressed in the central nervous system during a crucial phase of early development, but little else is known regarding its function. We hypothesize Prmt8 plays a role in synaptic maturation during development. To eva… Show more

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Cited by 17 publications
(23 citation statements)
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References 87 publications
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“…The regulation of gene expression, mRNA trafficking to synaptic sites, and numerous post-translational mechanisms, including protein trafficking, phosphorylation, ubiquitination, and acetylation, are all critical to neuronal function (Kandel, 2001). The protein argi-nine methyltransferase (PRMT) family of enzymes regulates multiple cellular processes and pathways; however, the roles of these proteins in brain function have only begun to be explored (Bedford and Clarke, 2009).…”
Section: Introductionmentioning
confidence: 99%
See 2 more Smart Citations
“…The regulation of gene expression, mRNA trafficking to synaptic sites, and numerous post-translational mechanisms, including protein trafficking, phosphorylation, ubiquitination, and acetylation, are all critical to neuronal function (Kandel, 2001). The protein argi-nine methyltransferase (PRMT) family of enzymes regulates multiple cellular processes and pathways; however, the roles of these proteins in brain function have only begun to be explored (Bedford and Clarke, 2009).…”
Section: Introductionmentioning
confidence: 99%
“…PRMT8 is unique among the PRMT proteins in that it is expressed specifically in the nervous system (Lee et al, 2005;. Furthermore, PRMT8 is a multifunctional protein, exhibiting both arginine methyltransferase and phospholipase D activities (Lee et al, 2005;.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Lee et al moreover, showed that the visual acuity of Prmt8 knockout mice were lower than wildtype mice suggesting a premature closure of critical period because of the hastened PNNs formation. These findings suggest that PRMT8 methylation activity is critical for the complete maturation of inhibitory circuitry by regulating the formation of PNNs that essentially act as structural brakes to critical period plasticity (Lee et al 2017).…”
Section: Prmt8smentioning
confidence: 87%
“…These findings suggest that PRMT8 methylation activity is critical for the complete maturation of inhibitory circuitry by regulating the formation of PNNs that essentially act as structural brakes to critical period plasticity (Lee et al . ).…”
Section: Molecular Mechanisms Regulating Gabaergic Developmentmentioning
confidence: 97%