Network modeling of the convective flow and diffusion of molecules adsorbing in monoliths and in porous particles packed in a chromatographic column

Structured adsorbents in gas separation processes

“…Meyers and Liapis [29,30] have employed pore network theory to determine in an a priori manner, the mass transfer and pressure drop characteristics of monoliths and in columns packed with porous particles. The outcome of their microscopic model was then employed in a dynamic macroscopic model to describe the dynamic behaviour of chromatographic columns.…”

Theory and Practice of UHPLC and UHPLC–MS

“…They also challenged the overly optimistic views of Afeyan et al, who claimed that a large fraction of the mobile phase is permeating through the particles, and argued that only a very small fraction, typically less than 1% of the flow, can percolate through the particulate porous packing material (Rodrigues et al, 2003). The theoretical treatment of convective flow was further developed by Liapis et al Meyers and Liapis, 1999).…”

Temperature-independent Detection of Heteroduplex and Homoduplex Fragments Applying Poly(glycidylmethacryate-co-divinylbenzene-based) Monoliths Modified to Strong Anion-exchanger

“…Monoliths are distinguished for fast analysis due to the ample channels available, which allow high flow-rate at low pressure-drop, as well as high mass transfer due to enhancing convection and lessening diffusion. 5,6 Monoliths have been prepared from different materials such as inorganic silica by sol-gel [7][8][9] or organic polymer such as metal-catalyzed ring opening metathesis polymerization (ROMP), 10 or free-radical polymerization based on styrene and acrylate chemistry. [11][12][13] The ease to make and derivatize, made these monoliths a good choice for present and future applications in bioseparation.…”