Network of biomarkers and their mediation effects on the associations between regular exercise and the incidence of cardiovascular &amp; metabolic diseases

Park, Joo Yong; Choi, Jaesung; Kim, Ji Eun; Lee, Mi-Young; Shin, Aesun; Lee, Jong koo; Kang, Daehee; Choi, Ji Yeob

doi:10.1038/s41598-021-92312-x

Cited by 7 publications

(7 citation statements)

References 57 publications

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“…Process function (model 4) in this package was performed to identify whether diabetes influence the relationship between NAFLD and PN as the mediator. If the 95% Bootstrap confidence intervals of the estimated indirect effect did not include number zero, the mediation effect were considered statistically significant 15 .…”

Section: Methodsmentioning

confidence: 99%

Association between nonalcoholic fatty liver disease and peripheral neuropathy in US population, a cross-sectional study

Tang

Xuan

et al. 2023

Sci Rep

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Nonalcoholic fatty liver disease (NAFLD) has become an important risk of type 2 diabetes mellitus (T2DM). Peripheral neuropathy (PN) is regarded as one of the main microvascular complications of diabetes. But the association of NAFLD with PN is still unclear. We aimed to investigate the association between NAFLD and PN in US population by conducting a cross-sectional study. We enrolled 3029 participants aged 40–85 years from National Health and Nutrition Examination Survey (NHANES) 1999–2004. NAFLD was defined as a US Fatty Liver Index (FLI) score ≥ 30, and PN was defined as having one or more insensate areas on either foot. Participants were divided into two groups (with or without PN). We performed multivariate logistic regression models to evaluate the association between NAFLD and PN. Subgroup analyses were used to find out whether the association was stable in different stratified groups. Sensitivity analyses were conducted to assess the robustness of the results. All the analyses were weighted. Among the individuals, 524 (17.3%) had PN and 1250 (41.27%) had NAFLD. In the multivariate logistic regression models, NAFLD was associated with an increased risk of PN (OR 1.44 [1.03 ~ 2.02]) after fully adjusting for covariates. In the subgroup analyses, NAFLD was significantly associated with PN in the age group (40–64 years), compared with those in the age group (65–85 years), (P for interaction: 0.004). The results of association of NAFLD with PN were stable in sensitivity analyses. In this cross-sectional study among US adults aged 40–85 years old, NAFLD was associated with an increased likelihood of prevalent PN.

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Section: Methodsmentioning

confidence: 99%

Association between nonalcoholic fatty liver disease and peripheral neuropathy in US population, a cross-sectional study

Tang

Xuan

et al. 2023

Sci Rep

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“…Possible reasons are that (i) the type and intensity of exercise differ between sexes ( Molanorouzi et al, 2015 ) and (ii) there are sex differences in the mechanisms of exercise effects on MetS. According to Park et al (2021) , regular exercise has no direct effect on the risk of metabolic disease but is mediated by other physiological factors; for instance, body composition (e.g., cell mass, mineral mass, and protein mass) plays an important role for men but obesity-related biomarkers (e.g., body fat) are key factors for women.…”

Section: Discussionmentioning

confidence: 99%

Sex differences in the change of exercise behavior leading to incident metabolic syndrome reduction: A community-based prospective study

Hsu

Yeh

Chen

et al. 2023

Preventive Medicine Reports

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“…Different types of exerkines may be more important during growth, maintenance, and aging [14], and identifying their actions may best support the desired outcome for fitness and health, especially with respect to oxidative stress and inflammation that contribute to chronic diseases [3]. Physical attributes and biomarkers have been proposed [18] to reflect the benefits of exercise on cardiovascular and metabolic diseases. However, the focus on exerkines throughout the life cycle has yet to be considered.…”

Section: Exerkines Of Metabolism and Energy Productionmentioning

confidence: 99%

Exerkines, Nutrition, and Systemic Metabolism

Watkins,

Smith,

Volpe

et al. 2024

Nutrients

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The cornerstones of good health are exercise, proper food, and sound nutrition. Physical exercise should be a lifelong routine, supported by proper food selections to satisfy nutrient requirements based on energy needs, energy management, and variety to achieve optimal metabolism and physiology. The human body is sustained by intermediary and systemic metabolism integrating the physiologic processes for cells, tissues, organs, and systems. Recently, interest in specific metabolites, growth factors, cytokines, and hormones called exerkines has emerged to explain cooperation between nutrient supply organs and the brain during exercise. Exerkines consist of different compounds described as signaling moiety released during and after exercise. Examples of exerkines include oxylipin 12, 13 diHOME, lipid hormone adiponectin, growth factor BDNF, metabolite lactate, reactive oxygen species (ROS), including products of fatty acid oxidation, and cytokines such as interleukin-6. At this point, it is believed that exerkines are immediate, fast, and long-lasting factors resulting from exercise to support body energy needs with an emphasis on the brain. Although exerkines that are directly a product of macronutrient metabolism such as lactate, and result from catabolism is not surprising. Furthermore, other metabolites of macronutrient metabolism seem to be candidate exerkines. The exerkines originate from muscle, adipose, and liver and support brain metabolism, energy, and physiology. The purpose of this review is to integrate the actions of exerkines with respect to metabolism that occurs during exercise and propose other participating factors of exercise and brain physiology. The role of diet and macronutrients that influence metabolism and, consequently, the impact of exercise will be discussed. This review will also describe the evidence for PUFA, their metabolic and physiologic derivatives endocannabinoids, and oxylipins that validate them being exerkines. The intent is to present additional insights to better understand exerkines with respect to systemic metabolism.

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Network of biomarkers and their mediation effects on the associations between regular exercise and the incidence of cardiovascular & metabolic diseases

Cited by 7 publications

References 57 publications

Association between nonalcoholic fatty liver disease and peripheral neuropathy in US population, a cross-sectional study

Association between nonalcoholic fatty liver disease and peripheral neuropathy in US population, a cross-sectional study

Sex differences in the change of exercise behavior leading to incident metabolic syndrome reduction: A community-based prospective study

Exerkines, Nutrition, and Systemic Metabolism

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