The pattern and impact of scientific collaborations depends on a country’s or region’s development stage. Prior to promoting scientific collaborations, it is crucial to understand what types of collaboration are more beneficial. By taking the stage of regional scientific development into consideration, this paper investigates the effect of various collaborations on regional scientific output. Our results highlight the differences between collaboration effects across regions at various capability levels. Scientifically weak regions benefit from more concentrated collaboration, in particular with advanced domestic regions. However, scientifically strong regions can benefit from a centrally located position in a broader collaboration network. Findings from this analysis indicate that international collaborations might not be beneficial a priori. Whether or not one region benefits from international collaborations depends on this region’s local capacity. Being embedded in a broad network structure can help increase one region’s publication output. However, such benefit is limited only to regions that have relatively higher research capacity.