2020
DOI: 10.1371/journal.pone.0239700
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Network theory of the bacterial ribosome

Abstract: In the past two decades, research into the biochemical, biophysical and structural properties of the ribosome have revealed many different steps of protein translation. Nevertheless, a complete understanding of how they lead to a rapid and accurate protein synthesis still remains a challenge. Here we consider a coarse network analysis in the bacterial ribosome formed by the connectivity between ribosomal (r) proteins and RNAs at different stages in the elongation cycle. The ribosomal networks are found to be d… Show more

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Cited by 5 publications
(4 citation statements)
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“…As we have observed in previous research, [4] the modular groups change as a function of the different states. Typically, 23S-D2 and D5 are found together in the same module but 23S-D0 is found in a second LSU domain.…”
Section: Plos Onesupporting
confidence: 78%
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“…As we have observed in previous research, [4] the modular groups change as a function of the different states. Typically, 23S-D2 and D5 are found together in the same module but 23S-D0 is found in a second LSU domain.…”
Section: Plos Onesupporting
confidence: 78%
“…A more careful analysis might explore the specific connectivity of the different hypothesized oldest regions and whether they include conserved residues. Nevertheless, the analysis, along with that of previous work [4] does allow some relatively broad observations. First, the evolution from the universal ribosome appears to be constrained in the development of new interactions.…”
Section: Centralitymentioning
confidence: 88%
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“…Ribosomal proteins form a network structure within the ribosome. 8,47,48 The terminal region of several ribosomal proteins lacks secondary structure. However, structural analyses suggest that their terminal regions interact with tRNA.…”
Section: Toc Graphicmentioning
confidence: 99%