Neue M�glichkeiten der Strukturanalyse von Knochenbiopsien bei Anwendung der Mikrocomputertomographie (?CT)

Delling, G.; Hahn, Moon Sik; Bonse, U.; Busch, Felix; Günnewig, Olaf; Beckmann, Felix; Uebbing, H.; Graeff, W.

doi:10.1007/s002920050112

Cited by 14 publications

(1 citation statement)

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“…Auch ist die Bedeutung der µCT bei der Diagnose anderer Krankheiten wie z.B. hämatologischer Systemerkrankungen, die eindeutig in zwei-dimensionalen Schnittpräpara-ten beurteilt werden können [5], noch unklar.…”

Section: Relevanz Für Die Präklinische Forschungunclassified

Mikro-CT

et al. 1999

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The strength and fracture resistance of bone is determined by the structure of the trabecular network and the cortical shell. While standard 2D techniques like histomorphometry are inadequate to assess the 3D nature of the trabecular network, isotropic 3D datasets of this network can be acquired with the new imaging modality of microCT. However, so far the quantitative analysis of the generated datasets, in particular the extraction of appropriate parameters describing the bone structure, has not been finally solved. In this article we describe the technology and applications of microCT systems relevant in the field of osteology. The most important technical features of current microCT systems in this context are: 1. A spatial resolution down to 5-10 microns can be achieved. 2. The maximum sample size is related to the desired resolution by a factor of approximately 1000, that is, a resolution of 10 microns limits the maximum sample size to approximately 1 cm. 3. Scan times for microCT systems vary between minutes and hours. Currently five areas for the application of microCT systems in osteology can be identified: 1. The search of parameters characterizing the 3D trabecular structure. 2. The application of finite element models to determine the biochemical competence of the structural parameters. 3. The use of microCT in preclinical trials to study drug effects in small animals. 4. The validation of analysis methods used in high-resolution in-vivo imaging systems. 5. The 3D quantification of modeling and remodeling processes.

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Section: Relevanz Für Die Präklinische Forschungunclassified

Mikro-CT

et al. 1999

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Röntgen‐Mikrotomographie

Bonse

1997

Phys. Bl.

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Abb. 1: Durch Rontgen-Mikrotomographie bei einer Wellenlange von ca. 70 pm gewonnenes Bild eines Mikrokallus (netzsrtiges Knochengebilde in der Bildmitte). Die Knochenprobe wurde durch eine Biopsie vom Beckenkamm eines an renaler Osteopathie (nierenbedingter Knochenkrankheit) erkrankten Patienten entnommen. Die Folge der Erkrankung sind ubergrofie Hohlraume, verdunnte, unterbrochene oder fehlende Stutzelemente (Trabekeln). Das netzartige Knochengebilde ist vermutlich die Reaktion des Organismus auf Mikrofrakturen, um diese wieder zu stabilisieren. ~ ~_ _ _ _ _ _ ___

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