Neuere Entwicklungen in der Pteridin‐Chemie

Pfleiderer, Wolfgang

doi:10.1002/ange.19630752102

Cited by 44 publications

(10 citation statements)

References 221 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…), is located in between the reflectance spectra of the two Colotis species. The spread of the reflectance spectra of orange and red wing areas, from which one and the same pigment (erythropterin; Pfleiderer, 1963;Descimon, 1971) was extracted, is discussed below.…”

Section: Article In Pressmentioning

confidence: 99%

“…The pigments all appeared to belong to one class, appropriately called the pterins (Descimon, 1975;Kayser, 1985). Leucopterin and isoxanthopterin absorb exclusively in the ultraviolet, and consequently inhomogeneous, scattering substances containing these pterins have a white color; xanthopterin and dihydroxanthopterin absorb in the violet as well, and thus produce a yellow color; and with the blue-absorbing erythropterin an orange or red color remains (Pfleiderer, 1963;Descimon, 1971;Watt, 1972).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Colors and pterin pigmentation of pierid butterfly wings

Wijnen

Leertouwer

Stavenga

2007

Journal of Insect Physiology

105

103

View full text Add to dashboard Cite

The reflectance of pierid butterfly wings is principally determined by the incoherent scattering of incident light and the absorption by pterin pigments in the scale structures. Coherent scattering causing iridescence is frequently encountered in the dorsal wings or wing tips of male pierids. We investigated the effect of the pterins on wing reflectance by local extraction of the pigments with aqueous ammonia and simultaneous spectrophotometric measurements. The ultraviolet-absorbing leucopterin was extracted prominently from the white Pieris species, and the violet-absorbing xanthopterin and blue-absorbing erythropterin were mainly derived from the yellow-and orangecolored Coliadinae, but they were also extracted from the dorsal wing tips of many male Pierinae. Absorption spectra deduced from wing reflectance spectra distinctly diverge from the absorption spectra of the extracted pigments, which indicate that when embedded in wing scales the pterins differ from those in solution. The evolution of pierid wing coloration is discussed. r

show abstract

Section: Article In Pressmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Colors and pterin pigmentation of pierid butterfly wings

Wijnen

Leertouwer

Stavenga

2007

Journal of Insect Physiology

105

103

View full text Add to dashboard Cite

show abstract

“…Recently, it has been suggested that the yellow color of these cells is due to sepiapterin (6), a compound that was first isolated from the sepia mutant of Drosophila and was shown to be a 7,8-dihydropterin carrying a lactoyl group at position C-6 (reviewed in Ref. 22). Accumulation of pteridines in the skin of various cyprinid species has also been described (19,23,24), and the main component of these, originally named ichthyopterin, was shown to be 7-oxobiopterin (25,26).…”

mentioning

confidence: 99%

Development of the Pteridine Pathway in the Zebrafish,Danio rerio

Ziegler¹,

McDonald²,

Heßlinger³

et al. 2000

Journal of Biological Chemistry

View full text Add to dashboard Cite

In the zebrafish, the peripheral neurons and the pigment cells are derived from the neural crest and share the pteridine pathway, which leads either to the cofactor tetrahydrobiopterin or to xanthophore pigments. The components of the pteridine pattern were identified as tetrahydrobiopterin, sepiapterin, 7-oxobiopterin, isoxanthopterin, and 2,4,7-trioxopteridine. The expression of GTP cyclohydrolase I activity during the first 24-h postfertilization, followed by 6-pyruvoyl-5,6,7,8-tetrahydropterin synthase and sepiapterin reductase, suggest an early supply of tetrahydrobiopterin for neurotransmitter synthesis in the neurons and for tyrosine supply in the melanophores. At 48-h postfertilization, sepiapterin formation branches off the de novo pathway of tetrahydrobiopterin synthesis. Sepiapterin, via 7,8-dihydrobiopterin and biopterin, serves as a precursor for the formation of 7-oxobiopterin, which may be further catabolized to isoxanthopterin and 2,4,7-trioxopteridine. Neither 7,8-dihydrobiopterin nor biopterin is a substrate for xanthine oxidoreductase. In contrast, both of these compounds are oxidized at C-7 by a xanthine oxidase variant form, which is inactivated by KCN, but is insensitive to allopurinol. The oxidase and the dehydrogenase form of xanthine oxidoreductase as well as the xanthine oxidase variant have specific developmental patterns. It follows that GTP cyclohydrolase I, the formation of sepiapterin, and the xanthine oxidoreductase family control the pteridine pathway in the zebrafish.

show abstract

“…some cases the problems of Isolation and characterization are caused by the low concentrations of pteridines in biological samples; they are generally present only in trace amounts (1,2). An exception is the relatively high concentrations which are found in the wings ofPteridae butterflies.…”

Section: Introductionmentioning

confidence: 99%

“…An excellent review of pteridine chemistry up to 1963 is given by Pfleiderer (2). Interesting and more recent aspects of analysis were described in the reports of the pteridines symposia held at Konstanz in 1973 (3) and at La Jolla, California, in 1978 (4), (5)(6)(7)(8)(9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Pteridines in the Assessment of Neoplasia

Hausen¹,

Wachter²

1982

CCLM

View full text Add to dashboard Cite

Summary: Biological processes which inight explain the association of pteridine excretion with proliferation are still unknown. Difficulties in the analysis and the determination of naturally occurring pteridines are described. The best quantitative estimations were achieved when measurement of non-reduced forms was attempted. The performance characteristics of such a method for neppterin by high performance liquid chromatography on reversed phase are given. Enhanced proliferation and dedifferentiation in cell cultures and organisms is paralleled by excretion of unconjugated pteridines into the medium or urine. Urinary neopterin in healthy subjects and in patients with benign diseases was only significantly raised in patients with viral diseases. Howevei, an elevation of urmary neopterin occurred in a wide variety of malignant diseases. In haematologic neoplasias correlatipns of neopterin values to clinicäl features, to tumour staging, and to laboratory data were apparent. The clinicäl Utility of neopterin measurement was also demonstrated in patients with gynaecologic tumours, particularly in patients with ovarian carcinoma. In both homogenepus patient groups the neopterin assay may provide an additional aid for prognosis and for monitoring therapy. Comparison of the neopterin assay with already established tumour marker substances at least revealed no inferiority in sensitivity. The present results justify extensive investigations in prder to eväluate further the clinicäl applicäbility of the neopterin assay. Pteridine in der Diagnostik von Neoplasien

show abstract

Neuere Entwicklungen in der Pteridin‐Chemie

Cited by 44 publications

References 221 publications

Colors and pterin pigmentation of pierid butterfly wings

Colors and pterin pigmentation of pierid butterfly wings

Development of the Pteridine Pathway in the Zebrafish,Danio rerio

Pteridines in the Assessment of Neoplasia

Contact Info

Product

Resources

About