Neues Verfahren zur Liposuktion und Fettaugmentation nach Chordektomie

Haubner, Frank; Lorenz, Anne; Kummer, Peter; Alvarez, Jean-Claude

doi:10.1055/s-0044-101380

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…In der Rubrik Tipps und Tricks wird die Technik der Eigenfettinjektion zur Stimmlippenaugmentation nach Laserresektion von frühen Stimmlippenkarzinomen beschrieben [5]. Insbesondere interessant ist die einfache und sichere Entnahme des Eigenfetts mit der Liposuktionskanüle.…”

Section: Sehr Geehrte Kolleginnen Und Kollegenunclassified

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Stöckli¹

2018

Laryngo-Rhino-Otol

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Section: Sehr Geehrte Kolleginnen Und Kollegenunclassified

Kommentar der Schriftleitung

Stöckli¹

2018

Laryngo-Rhino-Otol

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Primary injection laryngoplasty after chordectomy for small glottic carcinomas

Felicio‐Briegel

Sharaf

Haubner

et al. 2022

Eur Arch Otorhinolaryngol

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Objectives The purpose of this study was to analyze the short- and middle-term effects of primary injection laryngoplasty in patients having tumor resection within the same surgery concerning the vocal outcome. Injection laryngoplasty was performed after harvesting autologous adipose tissue via lipoaspiration. Methods A prospective study was performed with 16 patients (2 female; 14 male) who received tumor resection and an injection laryngoplasty using autologous adipose tissue during a single stage procedure. Multidimensional voice evaluation including videostroboscopy, patient self-assessment, voice perception, aerodynamics, and acoustic parameters was performed preoperatively, as well as 1.5, 3 and 6 months postoperatively. Results Results show an improvement in the roughness–breathiness–hoarseness (RBH) scale, voice dynamics and subjective voice perception 6 months postoperatively. Maintenance of Voice Handycap Index, jitter and shimmer could be observed 6 months postoperatively. There was no deterioration in RBH and subjective voice perception 2 and 6 weeks postoperatively. No complications occurred in the fat harvesting site. Conclusions Using the lipoaspiration and centrifugation approach, primary fat injection laryngoplasty shows short-term maintenance und middle-term improvement in voice quality in patients with vocal fold defect immediately after chordectomy 6 months postoperatively. Cancer recurrence rate is comparable to the reported cancer recurrence rate for laryngeal carcinoma and thus not elevated through primary augmentation.

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Human Adipose-Derived Stem/Stromal Cells Promote Proliferation and Migration in Head and Neck Cancer Cells

Sharaf

Eggersmann

Haider

et al. 2021

Cancers

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Human adipose-derived stem/stromal cells (ASCs) are increasingly used as auto-transplants in regenerative medicine to restore tissue defects or induce wound healing, especially in cancer patients. The impact of ASCs on squamous cell carcinoma of the upper aerodigestive tract (UAT) including head and neck and esophageal squamous cell carcinoma (HNSCC and ESCC) is not yet fully understood. ASCs were cultured from subcutaneous, abdominal lipoaspirates of five patients, who received auto-transplants to the head and neck. Supernatants were tested for paracrine effects in functional in vitro assays of proliferation of HNSCC tumor cell line FaDu and ESCC cell line Kyse30, and their cell migration/invasion capacities in Boyden chambers, in addition to endothelial tube formation assay using human umbilical vein endothelial cells (HUVECs). All ASC-derived supernatants enhanced proliferation of FaDu cells, invasive migration, and tube formation by HUVECs, compared to controls. Of five patients’ lipoaspirates, ASC-derived supernatants of four patients increased proliferation and invasive migration in Kyse30 cells. The data suggests that ASCs can promote tumor cell proliferation, invasiveness, and neo-angiogenesis in these tumor cell lines of the UAT and HUVEC in a paracrine manner. Although clinical studies on the subject of oncological safety are still needed, these findings emphasize the importance of complete tumor removal before ASCs are used in the head and neck.

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Neues Verfahren zur Liposuktion und Fettaugmentation nach Chordektomie

Cited by 3 publications

References 27 publications

Kommentar der Schriftleitung

Kommentar der Schriftleitung

Primary injection laryngoplasty after chordectomy for small glottic carcinomas

Human Adipose-Derived Stem/Stromal Cells Promote Proliferation and Migration in Head and Neck Cancer Cells

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