Neumonía atípica por Chlamydia psittaci . Cuatro casos relacionados

Arenas-Valls, Nuria; Chacón, Silvia; Pérez, Alfredo; Pozo, Roberto Del

doi:10.1016/j.arbres.2016.10.006

Cited by 14 publications

(2 citation statements)

References 7 publications

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“…A wholegenome alignment (WGA) was performed on the 61 C. psittaci genomes using SKA v1.0 6 . Prior to that alignment, fragmented genomes with more than one scaffold were mapped on the 6BC reference genome (NC_015470.1) using minimap2 v2.17 [71].…”

Section: Phylogenetic and Recombination Analysesmentioning

confidence: 99%

“…Mild symptoms are seen in most individuals infected, but immunocompromised persons are more likely to develop clinical signs. Occasionally, also apparently healthy individuals can be severely affected [6, 7]. In the last two decades, cases of zoonotic transmission were reported from psittacine birds [8], as well as ducks [9, 10], turkeys [11] and mixed domestic poultry [7] as the main sources.…”

Section: Introductionmentioning

confidence: 99%

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Extensive genomic divergence among 61 strains ofChlamydia psittaci

Sachse

Hölzer

Vorimore

et al. 2022

Preprint

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Chlamydia (C.) psittaci, the causative agent of avian chlamydiosis and human psittacosis, is a genetically heterogeneous species. Its broad host range includes parrots and many other birds, but occasionally also humans (via zoonotic transmission), ruminants, horses, swine and rodents. To assess whether there are genetic markers associated with host tropism we comparatively analyzed whole-genome sequences of 61 C. psittaci strains. Initially, poorly assembled genomes in public databases were subjected to clean-up, reassembly and polishing. Multiple sequence alignment of the genome sequences revealed four major clades within this species. Clade 1 represents the most recent lineage comprising 40/61 strains and contains 9/10 of the psittacine strains, including type strain 6BC, and 10/13 of human isolates. Clades 2-4 carry strains from different non-psittacine hosts. We found that clade membership correlates with classification schemes based on SNP types, ompA genotypes, multilocus sequence types as well as plasticity zone (PZ) structure and host preference. Genome analysis also revealed that i) sequence variation in the major outer membrane porin OmpA can result in 3D structural changes of immunogenic domains, ii) past host change of Clade 3 and 4 strains could be associated with loss of MAC/perforin in the PZ, rather than the large cytotoxin, iii) the distinct phylogeny of atypical strains (Clades 3 and 4) is also reflected in their repertoire of inclusion proteins (Inc family) and polymorphic membrane proteins (Pmps). Altogether, our study identified a number of genomic features that can be correlated with the phylogeny and host preference of C. psittaci strains.

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Section: Phylogenetic and Recombination Analysesmentioning

confidence: 99%