Neural and Hormonal Control of Gastric Secretion

Effects of spiroglumide, a gastrin receptor antagonist, on acid secretion in humans

“…One approach to prove the regulatory role of gastrin in acid secretion would be to demonstrate that exogenously administered gastrin in an amount that produces physiological gastrin blood levels stimulates gastric acid secretion in the same way as after a meal. Several features of the first part of the present study largely satisfy these criteria confirming previous reports [13,14]. First, synthetic, unsulphated human gastrin-17, which possesses all of the biological activity of larger forms of gastrin, was used for infusion.…”

Gastroprotective activity of the chloroform extract of the roots from Arctium lappa L.

“…Acute gastric injury induced in rats by the necrotizing agent ethanol was potently decreased by pretreating animals with the CE. Ethanol is a well-known necrotizing agent that destroys the protective factors of the mucosa (Wallace & Ma 2001), decreasing the mucous barrier (Hirschowitz 1983), gastric mucosal blood flow (reviewed by Abdel-Salam et al 2001) and levels of glutathione, a free-radical scavenger of the gastric mucosa (Repetto & Llesuy 2002). The destruction of these factors promotes haemorrhage, resulting in injury by oxidative damage to gastric epithelial cells.…”

Flavonoid-rich fraction of Maytenus ilicifolia Mart. ex. Reiss protects the gastric mucosa of rodents through inhibition of both H+,K+-ATPase activity and formation of nitric oxide

“…Ethanol is a very well known necrotizing agent that destroys the mucus barrier (Hirschowitz, 1983), increases vascular permeability (Szabo et al, 1985) and decreases non-proteic sulphydrilic groups (NP-SH) of the gastric mucosa (Repetto and Llesuy, 2002;Siegmund et al, 2003). Glutathione is the majoritary NP-SH of gastric mucosa and therefore constitutes one of the most important cytoprotective mechanisms (Cnubben et al, 2001), while mucus, which continuously coats over the gastric mucosa, prevents the injury of luminal acid, bacteria and noxious agents injury (Chen et al, 2005).…”