Neural and Hormonal Peptides in Rectal Biopsy Specimens From Patients With Chagas' Disease and Chronic Autonomic Failure

Long, Richard; Barnes, Alan; O’Shaughnessy, Denis; Bannister, R.; Bishop, Anne E.; Albuquerque, R. H.; McGregor, G.P.; Polak, Julia M.; Bloom, Stephen R.

doi:10.1016/s0140-6736(80)91054-5

Cited by 48 publications

(12 citation statements)

References 9 publications

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“…Considering that the chagasic mega colon has a greatly reduced number of all kinds of intramural autonomic cells [8. 10, 11], including peptidergic neurons [4,14], the absence of response to pentagastrin reported here suggests that the motor effect of this sub stance on the human sigmoid and rectum depends on the myenteric nervous pathways, and cannot occur if these structures have been severely damaged.…”

Section: Discussionmentioning

confidence: 87%

Effect of Pentagastrin on the Motor Activity of the Dilated and Nondilated Sigmoid and Rectum in Chagas’ Disease

et al. 1983

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In order to evaluate the effect of pentagastrin on the motor activity of the sigmoid and rectum in patients with Chagas’ disease, manometric studies were performed on 22 chagasic patients, 11 without and 11 with megacolon, and 11 control subjects. Pentagastrin had a stimulating effect on the sigmoid and rectum in control subjects as well as in chagasic patients without megacolon. In chagasic patients with megacolon, pentagastrin had no effect on sigmoid or rectum motility, probably as a result of the intrinsic denervation known to occur in this disease. The findings suggest that the motor effect of pentagastrin on the human sigmoid and rectum depends on the myenteric nervous pathways.

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Section: Discussionmentioning

confidence: 87%

Effect of Pentagastrin on the Motor Activity of the Dilated and Nondilated Sigmoid and Rectum in Chagas’ Disease

et al. 1983

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“…The denervation of the gut leads to profound changes in the mucosal peptide concentration (23). Thus, it is quite plausible that the combination of neuropeptide concentration with other factors may be able to inhibit the carcinogenic process, since it is well known that the gut neuroendocrine system is significantly altered in the denervated colon and in megacolon (27)(28)(29)(30).…”

Section: Discussionmentioning

confidence: 99%

Intrinsic denervation of the colon is associated with a decrease of some colonic preneoplastic markers in rats treated with a chemical carcinogen

Vespúcio

Turatti

Modiano

et al. 2008

Braz J Med Biol Res

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Denervation of the colon is protective against the colon cancer; however, the mechanisms involved are unknown. We tested the hypothesis that the denervated colonic mucosa could be less responsive to the action of the chemical carcinogen dimethylhydrazine (DMH). Three groups of 32 male Wistar rats were treated as follows: group 1 (G1) had the colon denervated with 0.3 mL 1.5 mM benzyldimethyltetradecylammonium (benzalkonium chloride, BAC); G2 received a single ip injection of 125 mg/kg DMH; G3 was treated with BAC + the same dose and route of DMH. A control group (Sham, N = 32) did not receive any treatment. Each group was subdivided into four groups according to the sacrifice time (1, 2, 6, and 12 weeks after DMH). Crypt fission index, ß-catenin accumulated crypts, aberrant crypt foci, and cell proliferation were evaluated and analyzed by ANOVA and the Student t-test. G3 animals presented a small number of aberrant crypt foci and low crypt fission index compared to G2 animals after 2 and 12 weeks, respectively. From the second week on, the index of ß-catenin crypt in G3 animals increased slower than in G2 animals. From the 12th week on, G2 animals presented a significant increase in cell proliferation when compared to the other groups. Colonic denervation plays an anticarcinogenic role from early stages of colon cancer development. This finding can be of importance for the study of the role of the enteric nervous system in the carcinogenic process.

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“…Studies of rectal biopsy samples from patients with Chagas' disease have shown reduced levels of substance P, vasoactive intestinal polypeptide, somatostatin, and enterglucagon (141). These neurohumoral peptides do not show reduced levels in patients with chronic autonomic neuropathy (141), which is an abnormality of preganglionic extrinsic nerves. However, the elaboration of these products is neuronally mediated, and the decreases that have been reported in patients with Chagas' disease are probably due to a reduction in ganglion cells.…”

Section: Colonmentioning

confidence: 97%

“…These infusions have no effect in chagasic patients with megacolon, suggesting that the colonic myenteric plexus includes enkephalin-containing neurons (145). Studies of rectal biopsy samples from patients with Chagas' disease have shown reduced levels of substance P, vasoactive intestinal polypeptide, somatostatin, and enterglucagon (141). These neurohumoral peptides do not show reduced levels in patients with chronic autonomic neuropathy (141), which is an abnormality of preganglionic extrinsic nerves.…”

Section: Colonmentioning

confidence: 99%

Chagas' disease

et al. 1992

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Chagas' disease, caused by Trypanosoma cruzi, is an important cause of morbidity in many countries in Latin America. The important modes of transmission are by the bite of the reduviid bug and blood transfusion. The organism exists in three morphological forms: trypomastigotes, amastigotes, and epimastigotes. The mechanism of transformation and differentiation is currently being explored, and signal transduction pathways of the parasites may be involved in this process. Parasite adherence to and invasion of host cells is a complex process involving complement, phospholipase, penetrin, neuraminidase, and hemolysin. Two clinical forms of the disease are recognized, acute and chronic. During the acute stage pathological damage is related to the presence of the parasite, whereas in the chronic stage few parasites are found. In recent years the roles of tumor necrosis factor, gamma interferon, and the interleukins in the pathogenesis of this infection have been reported. The common manifestations of chronic cardiomyopathy are arrhythmias and thromboembolic events. Autoimmune, neurogenic, and microvascular factors may be important in the pathogenesis of the cardiomyopathy. The gastrointestinal tract is another important target, and "mega syndromes" are common manifestations. The diagnosis and treatment of this infection are active areas of investigation. New serological and molecular biological techniques have improved the diagnosis of chronic infection. Exacerbations of T. cruzi infection have been reported for patients receiving immuno-suppressive therapy and for those with AIDS.

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Neural and Hormonal Peptides in Rectal Biopsy Specimens From Patients With Chagas' Disease and Chronic Autonomic Failure

Cited by 48 publications

References 9 publications

Effect of Pentagastrin on the Motor Activity of the Dilated and Nondilated Sigmoid and Rectum in Chagas’ Disease

Effect of Pentagastrin on the Motor Activity of the Dilated and Nondilated Sigmoid and Rectum in Chagas’ Disease

Intrinsic denervation of the colon is associated with a decrease of some colonic preneoplastic markers in rats treated with a chemical carcinogen

Chagas' disease

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