Neural aromatization and the control of sexual behavior

Freeman, Louise M.; Rissman, Emilie F.

doi:10.1016/s1043-2760(96)00156-7

Cited by 22 publications

(11 citation statements)

References 43 publications

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“…The precise causes contributing to the decrease in fertility upon administration of the two agonists in our study are currently being pursued. In rodents, male sexual behaviour and ability to mate is under the influence of the testosterone, yet E 2 is also thought to play an important role (Freeman & Rissman 1996, McCarthy & Albrecht 1996. It is evident that there was a decrease in potency in the treatment groups where there was a decrease in serum testosterone levels ( Fig.…”

Section: Discussionmentioning

confidence: 93%

Effect of estrogen receptor-subtype-specific ligands on fertility in adult male rats

Dumasia

Kumar

Kadam

et al. 2015

Journal of Endocrinology

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Maintenance of normal male fertility relies on the process of spermatogenesis which is under complex endocrine control by mechanisms involving gonadotropin and steroid hormones. Although testosterone is the primary sex steroid in males, estrogen is locally produced in the testis and plays a very crucial role in male fertility. This is evident from presence of both the estrogen receptors alpha (ERa) and beta (ERb) in the testis and their absence, as in the case of knockout mice models, leads to sterility. The present study was undertaken to understand individual roles of the two ERs in spermatogenesis and their direct contribution towards the maintenance of male fertility using receptor-subtype-specific ligands. Administration of ERa and b agonists to adult male rats for 60 days results in a significant decrease in fertility, mainly due to an increase in pre-and post-implantation loss and a concomitant decrease in litter size and sperm counts. Our results indicate that ERa is mainly involved in negative feedback regulation of gonadotropin hormones, whereas both ERs are involved in regulation of prolactin and testosterone production. Histological examinations of the testis reveal that ERb could be involved in the process of spermiation since many failed spermatids were observed in stages IX-XI following ERb agonist treatment. Our results indicate that overactivation of estrogen signaling through either of its receptors can have detrimental effects on the fertility parameters and that the two ERs have both overlapping and distinct roles in maintenance of male fertility.

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Section: Discussionmentioning

confidence: 93%

Effect of estrogen receptor-subtype-specific ligands on fertility in adult male rats

Dumasia

Kumar

Kadam

et al. 2015

Journal of Endocrinology

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“…Such a capacity may be typical of species that are exposed to some T from the placenta or from male siblings during prenatal development [26, 28]. Given the role of tonic T in activating female sexual behavior in the musk shrew [29] and the suggestion that T levels may actually increase during pregnancy [11], it is possible that female musk shrews receive substantial T exposure as fetuses. This view is consistent with the observation of mounting behavior in some control animals in this and previous studies [15] and also with our observations (unpublished) that female musk shrews, like rats [28], occasionally mount unresponsive males.…”

Section: Discussionmentioning

confidence: 99%

“…Sexual behavior in the female musk shrew is activated much like male sexual behavior in other species [11]. Female musk shrews have no behavioral estrus cycle, do not show the lordosis reflex and are tonically sexually receptive; mating is activated by ovarian and adrenal T [12–13].…”

Section: Introductionmentioning

confidence: 99%

“…Females initially respond to this attention with aggression in the form of male-directed vocalizations, lunges and attacks that are occasionally fierce enough to bloody his nose. Eventually, the females’ behavior shifts from aggression to receptivity, as indicated by “tail-wagging” behavior (presentation of the rump and a characteristic swishing movement of the tail) and reduced aggression toward the male [11, 13]. Shortly after tail-wagging begins, the male typically achieves his first successful mount.…”

Section: Introductionmentioning

confidence: 99%

“…In the musk shrew, neural aromatization of gonadal T to E2 in the medial preoptic area is essential to the activation of copulatory behavior in both sexes [11]. Neonatal testosterone propionate (TP) treatment of female musk shrews both masculinizes (as measured by a decrease in mount latency and an increase in mount rate) and defeminizes (as measured by an increase in male-directed aggression during tail-wagging and a resultant reduced intromission efficiency by the male) copulatory behavior [15], but whether T had this organizational effect via AR or after conversion to E2 was unknown.…”

Section: Introductionmentioning

confidence: 99%

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Neonatal DHT but not E2 speeds induction of sexual receptivity in the musk shrew

Ewton¹,

Siboni²,

Jackson³

et al. 2010

Physiology & Behavior

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Neural aromatization of testosterone (T) to estrogen during development is thought to be important for sexual differentiation of many altricial mammals. We evaluated the effects of neonatal injections of the non-aromatizable androgen dihydrotestosterone propionate (DHTP) and estradiol (E2) on the copulatory behavior of the female musk shrew, an altricial insectivore. Following adult ovariectomy and replacement T, animals were paired with a stimulus female for two 60-minute copulatory behavior tests. The latency to induce sexual receptivity (in the form of tail-wagging by the female), mount latency and total number of mounts were recorded in experimental females and in a group of untreated control males. While neither hormone treatment significantly affected mounting behavior, DHTP-treated animals induced receptivity faster and with latencies not significantly different from intact males, suggesting that early non-aromatizable androgens can have masculinizing actions by either increasing sexual motivation or making the treated animal more attractive to the stimulus female. Reliance on androgenic rather than estrogenic metabolites for the differentiation of courtship behaviors conforms to the pattern seen more typically in primates than rodents.

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Time Course of Effects of Testosterone Administration on Sexual Arousal in Women

Tuiten

Honk²,

Koppeschaar³

et al. 2000

Arch Gen Psychiatry

251

184

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Neural aromatization and the control of sexual behavior

Cited by 22 publications

References 43 publications

Effect of estrogen receptor-subtype-specific ligands on fertility in adult male rats

Effect of estrogen receptor-subtype-specific ligands on fertility in adult male rats

Neonatal DHT but not E2 speeds induction of sexual receptivity in the musk shrew

Time Course of Effects of Testosterone Administration on Sexual Arousal in Women

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