Neural bases of prospective memory: A meta-analysis and the “Attention to Delayed Intention” (AtoDI) model

Cona, Giorgia; Scarpazza, Cristina; Sartori, Giuseppe; Moscovitch, Morris; Bisiacchi, Patrizia

doi:10.1016/j.neubiorev.2015.02.007

Cited by 169 publications

(227 citation statements)

References 97 publications

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“…While the precise functions of the angular gyrus remain unclear, degeneration of this region in AD may disrupt the integration of information and imparting of meaning towards an intended action [69]. Our findings resonate with the conceptualization of PM as lying at the interface between the domains of memory and attention, with successful PM performance requiring a shift between external stimuli (e.g., cues) and representations of intentions stored in memory [18]. While the precise neurocognitive mechanisms driving Time-based PM deficits in AD remain unclear, our behavioral and neuroimaging analyses underscore the multifactorial nature of PM dysfunction in AD, likely reflecting the deterioration of episodic memory, compromised time perception mechanisms, and disruption of core cognitive control processes.…”

Section: Discussionsupporting

confidence: 78%

“…Prefrontal regions, including the rostral prefrontal cortex (BA10), consistently activate during PM performance in healthy individuals potentially reflecting intention maintenance [17,18]. Lesions to prefrontal regions have been shown to significantly compromise PM function [19,20], corroborating the neuroimaging findings.…”

Section: Introductionmentioning

confidence: 55%

“…Activation of parietal regions such as the angular gyrus and supramarginal gyrus, in concert with the prefrontal cortices, is consistently reported in functional neuroimaging studies of PM performance in healthy individuals [18]. These sites form part of a broader cognitive control network, which supports sustained attention and goal-directed cognition, as well as a range of cognitively demanding tasks such as planning and problem-solving [67].…”

Section: Discussionmentioning

confidence: 96%

“…Regions beyond the frontal lobes are also implicated in successful PM function. For example, parietal activation may support allocation of attention towards external stimuli and the PM intention, as well as maintenance and retrieval of the intention itself [18]. Moreover, medial temporal lobe regions, including the hippocampus, are implicated in the retrieval of an action or recognition of a cue during PM tasks [21,22].…”

Section: Introductionmentioning

confidence: 99%

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Prospective Memory Impairments in Alzheimer’s Disease and Behavioral Variant Frontotemporal Dementia: Clinical and Neural Correlates

Dermody

Hornberger

Piguet

et al. 2016

JAD

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Section: Discussionsupporting

confidence: 78%

Section: Introductionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Prospective Memory Impairments in Alzheimer’s Disease and Behavioral Variant Frontotemporal Dementia: Clinical and Neural Correlates

Dermody

Hornberger

Piguet

et al. 2016

JAD

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“…Specifically, the research expected to replicate the e4 advantage in PM retrieval, and target detection on the RVIP, in comparison to the population norm (e3 homozygotes), at the cost of response latency in this group. The processes targeted by these tasks include goal maintenance, switching, monitoring and updating, all of which burden executive attention and load on frontal lobes (Cona et al, 2015;Coull et al, 1996). In addition, a computerized Stroop-switch task was used to explore if errors on this task differentiate carriers of a genetic risk for AD as early as mid-adulthood.…”

Section: Introductionmentioning

confidence: 99%

The APOE paradox: do attentional control differences in mid-adulthood reflect risk of late-life cognitive decline

Lancaster

Tabet

Rusted

2016

Neurobiology of Aging

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Article (Accepted Version) http://sro.sussex.ac.uk Lancaster, Claire, Tabet, Naji and Rusted, Jennifer (2016) The APOE paradox: how do attentional control differences in mid-adulthood reflect risk of late-life cognitive decline. Neurobiology of Aging, This version is available from Sussex Research Online: http://sro.sussex.ac.uk/62415/ This document is made available in accordance with publisher policies and may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the URL above for details on accessing the published version. Copyright and reuse:Sussex Research Online is a digital repository of the research output of the University.Copyright and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable, the material made available in SRO has been checked for eligibility before being made available.Copies of full text items generally can be reproduced, displayed or performed and given to third parties in any format or medium for personal research or study, educational, or not-for-profit purposes without prior permission or charge, provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. AbstractPossession of an APOE e4 allele is an established risk factor for Alzheimer's disease, while the less commonly studied e2 variant is premised to offer some protection. This research explores the purported deleterious-protective dichotomy of APOE variants on attentional control in mid-adulthood. 66 volunteers, aged 45-55 years, completed three tasks that provided complementary measures of attentional control: prospective memory, sustained attention and inhibition. Performance was compared between e2 carriers, e4 carriers and e3 homozygotes (the population norm). Carriers of the e4 allele showed subtle disadvantages, compared to the e3 group, in accuracy of Stroop task and prospective memory performance. Contrary to expectations, e2 carriers showed performance disadvantages in sustained attention. The finding of detrimental effects in attentional control for both e4 and e2 complicates the current model that proposes opposing effects of these variants on later-life cognition. Future research is needed to understand how cognitive differences develop with increasing age, and the physiological mechanisms that underpin these changes.

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Selective microstructural integrity impairments of the anterior corpus callosum are associated with cognitive deficits in obstructive sleep apnea

et al. 2019

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BackgroundThere is some evidence that obstructive sleep apnea (OSA) patients have white matter integrity abnormality in the corpus callosum (CC). However, whether the CC subregions are differentially affected in OSA is largely unknown.MethodsTwenty patients with OSA and 24 well‐matched healthy controls were enrolled and underwent diffusion tensor imaging (DTI) and clinical and cognitive assessments. DTI tractography was used to reconstruct the CC which was divided into five subregions. Intergroup differences in multiple diffusion metrics of each CC subregion and their correlations with clinical and cognitive parameters were tested.ResultsIn comparison with healthy controls, OSA patients exhibited white matter integrity alterations in the anterior CC, characterized by increased radial diffusivity (RD) in the subregion 1 and decreased fractional anisotropy (FA) along with increased mean diffusivity (MD) and RD in the subregion 2. Moreover, we found that the lower microstructural integrity in the anterior CC was correlated with worse prospective memory and sustained attention in OSA patients.ConclusionsThese findings indicate that the selective impairments of the anterior CC may help clarify the neural correlates of cognitive impairments in OSA.

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Neural bases of prospective memory: A meta-analysis and the “Attention to Delayed Intention” (AtoDI) model

Cited by 169 publications

References 97 publications

Prospective Memory Impairments in Alzheimer’s Disease and Behavioral Variant Frontotemporal Dementia: Clinical and Neural Correlates

Prospective Memory Impairments in Alzheimer’s Disease and Behavioral Variant Frontotemporal Dementia: Clinical and Neural Correlates

The APOE paradox: do attentional control differences in mid-adulthood reflect risk of late-life cognitive decline

Selective microstructural integrity impairments of the anterior corpus callosum are associated with cognitive deficits in obstructive sleep apnea

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