Neural conduction, visual motion detection, and insect flight behaviour are disrupted by low doses of imidacloprid and its metabolites

Parkinson, Rachel H.; Gray, John R.

doi:10.1016/j.neuro.2019.02.012

Cited by 22 publications

(14 citation statements)

References 30 publications

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“…Neonicotinoid-mediated impairment of foraging behavior has been reported for bumblebees [32,64,65]. Flight behavior of locusts ( Locusta migratoria L.) is impaired by imidacloprid [37] and the migration of a songbird is also impaired by this compound [38]. The possible impact of sub-lethal nectar-borne neonicotinoids on monarch migration should be investigated as a matter of urgency.…”

Section: Discussionmentioning

confidence: 99%

“…Sub-lethal effects may have substantial impacts on pollinator population level parameters [35] and neonicotinoids have been implicated in the global decline of pollinators [36]. Neonicotinoid-induced impairment of flight behavior and migratory ability have been described recently in a locust and a songbird [37,38]. Direct and indirect effects of neonicotinoids on non-target vertebrates have also been reported from rats, mice, rabbits, birds, frogs, fish, reptiles and deer [39,40].…”

Section: Introductionmentioning

confidence: 99%

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A Neonicotinoid Insecticide at a Rate Found in Nectar Reduces Longevity but Not Oogenesis in Monarch Butterflies, Danaus plexippus (L.). (Lepidoptera: Nymphalidae)

James

2019

Insects

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The monarch butterfly in North America has suffered a serious population decline since the mid-1990s. The introduction and widespread use of neonicotinoid insecticides during the same time period has been suggested as a potential driver of this decline but no studies have looked at the impact of these insecticides on adult monarchs. A brief laboratory study assessed the impact of Imidacloprid, the most commonly used neonicotinoid, on western monarch butterfly longevity and oogenesis. Imidacloprid at 23.5 ppb, a field-realistic rate reported from wild nectar and pollen, was fed ad libitum to newly-eclosed monarchs in a sugar-based diet for 22 days. Treated monarchs showed reduced longevity, suffering 78.8% mortality by day 22, compared to 20% in untreated monarchs. Prior to death, butterflies exhibited signs of poisoning including uncoordinated flapping of wings and uncontrolled vibrating of wings and body. Imidacloprid did not reduce egg production. Shortened adult longevity has serious consequences for monarch population development, migration and overwintering. The potential widespread impact of imidacloprid-contaminated crop and wild flower nectar, may be a significant driver of monarch population decline. More research on the impact of neonicotinoid insecticides on the monarch and other butterflies should be viewed as a serious priority.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Neonicotinoid Insecticide at a Rate Found in Nectar Reduces Longevity but Not Oogenesis in Monarch Butterflies, Danaus plexippus (L.). (Lepidoptera: Nymphalidae)

James

2019

Insects

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“…This is a significant finding, as SFX and IMD act on the same target, the nAChR, although they are metabolized through different pathways (8). We previously demonstrated that metabolites of IMD, including IMD-olefin and 5-hydroxy IMD, display toxic effects on this collision avoidance pathway equal to or greater than those of the parent compound (12). The detoxification pathway of SFX may result in metabolites that do not bind to the nAChR or can be more readily excreted, suggesting that SFX would cause toxicity by binding to the nAChR before metabolism.…”

Section: Discussionmentioning

confidence: 99%

“…While sublethal oral treatment with IMD resulted in robust effects on collision avoidance behavior, as seen previously with an injected dose (13), SFX did not affect this behavior at sublethal concentrations. This unanticipated result suggests that compared with SFX, IMD may bind more readily to the nAChR subtypes found in the locust optic lobes and central nervous system, or that the metabolites of IMD heighten its sublethal effects (12). The differences in sublethal toxicity between IMD and SFX were also reflected in their effects on the population responses of descending visual interneurons.…”

Section: Discussionmentioning

confidence: 99%

“…The neonic imidacloprid (IMD) has previously been shown to affect visual motion processing and collision avoidance behavior in the locust (Locusta migratoria) (12,13). The locust possesses a tractable and well-described descending interneuron, the descending contralateral movement detector (DCMD), which responds preferentially to objects approaching on a direct collision course (looming) (14,15).…”

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Neonicotinoid and sulfoximine pesticides differentially impair insect escape behavior and motion detection

Parkinson

Zhang

Gray

2020

Proc. Natl. Acad. Sci. U.S.A.

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Insect nervous systems offer unique advantages for studying interactions between sensory systems and behavior, given their complexity with high tractability. By examining the neural coding of salient environmental stimuli and resulting behavioral output in the context of environmental stressors, we gain an understanding of the effects of these stressors on brain and behavior and provide insight into normal function. The implication of neonicotinoid (neonic) pesticides in contributing to declines of nontarget species, such as bees, has motivated the development of new compounds that can potentially mitigate putative resistance in target species and declines of nontarget species. We used a neuroethologic approach, including behavioral assays and multineuronal recording techniques, to investigate effects of imidacloprid (IMD) and the novel insecticide sulfoxaflor (SFX) on visual motion-detection circuits and related escape behavior in the tractable locust system. Despite similar LD50 values, IMD and SFX evoked different behavioral and physiological effects. IMD significantly attenuated collision avoidance behaviors and impaired responses of neural populations, including decreases in spontaneous firing and neural habituation. In contrast, SFX displayed no effect at a comparable sublethal dose. These results show that neonics affect population responses and habituation of a visual motion detection system. We propose that differences in the sublethal effects of SFX reflect a different mode of action than that of IMD. More broadly, we suggest that neuroethologic assays for comparative neurotoxicology are valuable tools for fully addressing current issues regarding the proximal effects of environmental toxicity in nontarget species.

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Sublethal Imidacloprid Administration to Honey Bee Workers is More Lethal to the Queen Larvae

Chen,

Tzeng,

Lin

et al. 2024

Enviro Toxic and Chemistry

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Imidacloprid and other neonicotinoid insecticides severely impact the performance and survival of honey bees and other pollinators. In the present study, we focused on the gene expression profile of newly emerged Apis mellifera queen bees after sublethal imidacloprid treatment during the larval stage. Royal jelly containing 1 ppb imidacloprid was provided to larvae for 3 consecutive days (2–4 days postemergence). Queen larvae treated with imidacloprid showed lower capping and emergence rates (35.5% and 24.22%, respectively) than did control larvae (61.68% and 52.95%, respectively), indicating a high failure rate of queen rearing associated with imidacloprid exposure during the larval stage. The molecular response to imidacloprid treatment was examined next. By comparing the gene expression profiles of imidacloprid‐treated queen larvae and those of control queen larvae using DESeq2, we identified 215 differentially expressed genes, with 105 and 111 up‐ and downregulated genes, respectively. Gene Ontology results indicated that chitin binding– and calcium ion binding–related genes were upregulated, while phototransduction‐ and visual perception–related genes were downregulated. The high mortality rate and altered gene expression profiles suggest that treatment with even 1 ppb imidacloprid can severely impact queen bee survival. Environ Toxicol Chem 2024;00:1–11. © 2024 SETAC

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Neural conduction, visual motion detection, and insect flight behaviour are disrupted by low doses of imidacloprid and its metabolites

Cited by 22 publications

References 30 publications

A Neonicotinoid Insecticide at a Rate Found in Nectar Reduces Longevity but Not Oogenesis in Monarch Butterflies, Danaus plexippus (L.). (Lepidoptera: Nymphalidae)

A Neonicotinoid Insecticide at a Rate Found in Nectar Reduces Longevity but Not Oogenesis in Monarch Butterflies, Danaus plexippus (L.). (Lepidoptera: Nymphalidae)

Neonicotinoid and sulfoximine pesticides differentially impair insect escape behavior and motion detection

Sublethal Imidacloprid Administration to Honey Bee Workers is More Lethal to the Queen Larvae

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