2015
DOI: 10.1016/j.pnpbp.2014.08.011
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Neural correlates during working memory processing in major depressive disorder

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Cited by 74 publications
(69 citation statements)
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References 90 publications
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“…More specifically, our results are corroborated by diverse findings from previous studies highlighting the importance of these brain regions in acute MDD, including reports on increased resting-state functional connectivity between the insula and the OFC associated with altered interoceptive awareness in depressed patients. [45][46][47][48][49] As comparable alterations were not observed in individuals at familial risk for MDD in our study, the present work might highlight differential functional connectivity in this circuit as a possible statedependent neural substrate of altered interoception and social emotional processing as core features of acute MDD.…”
Section: Discussionsupporting
confidence: 71%
“…More specifically, our results are corroborated by diverse findings from previous studies highlighting the importance of these brain regions in acute MDD, including reports on increased resting-state functional connectivity between the insula and the OFC associated with altered interoceptive awareness in depressed patients. [45][46][47][48][49] As comparable alterations were not observed in individuals at familial risk for MDD in our study, the present work might highlight differential functional connectivity in this circuit as a possible statedependent neural substrate of altered interoception and social emotional processing as core features of acute MDD.…”
Section: Discussionsupporting
confidence: 71%
“…20 Alternatively, it could be that DLPFC hypoactivation is not a robust finding in MDD. In support of this latter interpretation, Wang et al 43 meta-analyzed 11 voxel-based fMRI studies of MDD patients that used working memory tasks, and found reduced activation in the insula, precentral gyrus and precuneus, but not in the DLPFC or other frontal regions. Instead, there was increased activation in the left inferior and middle frontal gyrus and the left precentral gyrus.…”
Section: Discussionmentioning
confidence: 95%
“…The PFC is strongly connected with the amygdala and the hippocampus and the activity of its different subdivisions has been widely studied in depressed patients. Hence, although studies seemed consistent in showing a lower activity of dorsolateral PFC in resting state analyses of MDD patients (Fitzgerald et al 2008; Hamilton et al 2012; Limon et al 2016; Zhang et al 2015a; Zhong et al 2016), meta-analyses of this region during task processing and especially in response to emotional stimuli with a negative valence have shown either a higher activity (Miller et al 2015; Wang et al 2015b; Zhang et al 2013) or a lower activity (Groenewold et al 2013; Hamilton et al 2012; Zhang et al 2015a). This might be due to the various parameters of the studies such as age of individuals, severity of depression, or whether there were medicated or not.…”
Section: Brain Regions and Neurocircuits Involved In Depression: Neurmentioning
confidence: 98%