Neural correlates of asymptotic avoidance and classical conditioned leg flexion

Cassady, J. Michael; Thompson, Richard F.; Weinberger, Norman M.

doi:10.1016/0014-4886(73)90136-2

Cited by 14 publications

(3 citation statements)

References 5 publications

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“…The issues focused on the fate of sensory signals when they predicted an 118 N.M. WEINBERGER important event, such as reward or negative reinforcement. In fact, systematic increases in CS-evoked LFPs could be obtained in the same dogs that were successively switched between classic conditioning and instrumental avoidance conditioning with the same CS and US, despite the learning of different responses for the two types of conditioning (Cassady et al, 1973). This issue was part of the larger program of seeking the neural circuitry underlying learning and memory.…”

Section: Background Findingsmentioning

confidence: 96%

New perspectives on the auditory cortex

Weinberger

2015

Handbook of Clinical Neurology

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Section: Background Findingsmentioning

confidence: 96%

New perspectives on the auditory cortex

Weinberger

2015

Handbook of Clinical Neurology

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“…Standard scores ([CSbioci, -pre-CSbiock]/SD pre -cs session and [UCSbiock -pre-CSbiock]/SD pre .cs session) were then computed for each block of trials for the CS period and the UCS period. The procedure provides an index of increased or decreased neural activity relative to background, the pre-CS period (Cassady, Cole, Thompson, & Weinberger, 1973;Disterhoft & Olds, 1972;Gabriel, Wheeler, & Thompson, 1973;Thompson et al, 1976).…”

Section: Data Acquisition and Analysismentioning

confidence: 99%

Neuronal unit activity in the abducens nucleus during classical conditioning of the nictitating membrane response in the rabbit (Oryctolagus cuniculus).

Cegavske¹,

Patterson²,

Thompson³

1979

Journal of Comparative and Physiological Psychology

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Neuronal unit activity was recorded from the abducens (6th nerve) nucleus, the "final common path," during classical conditioning of the nictitating membrane (NM) response in the rabbit, with the use of a tone conditioned stimulus, an air puff unconditioned stimulus (UCS), 250-msec interstimulus interval, and 60-sec intertrial interval. Animals were given 2 days of conditioning training (104 trials in eight blocks per day) and 1 day of extinction. Control animals were given comparable periods of stimulus presentations, explicitly unpaired. Activity of small clusters of units-"multiple unit" recording-was compared with the amplitude-time course of the NM response. Between-blocks comparisons of neural and behavioral responses indicated an essentially perfect correlation during acquisition of the conditioned response (Day 1, r = .99; Day 2, r = .98) and a slightly lower correlation during extinction (r = .93) for the conditioning animals. Within-blocks comparisons indicated a close correspondence between the histograms of unit activity and the amplitude-time course of the NM response for the conditioning animals in all phase of training and for the control animals in the UCS trial blocks. *Analysis of the neural mechanisms of of processing, it is necessary to compare learning and memory has proved extraordi-putative learning-related changes in other narily difficult. The goal is localization and brain structures with the temporal course of analyses of the alterations in neuronal ac-altered activity in motoneurons. tivity that code learning-the "engram"We have adopted classical conditioning of

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“…Numerous studies of classical and instrumental conditioning in animals have demonstrated that responses to conditioned and discriminative stimuli in sensory systems are altered systematically by associative processes (for reviews, see John, 1961;Sokolov, 1977;Thompson, Patterson, & Teyler, 1972). Such response plasticity is particularly evident in sensory cortex; it has been documented most extensively in auditory cortex (e.g., Buchwald, Halas, & Schramm, 1966;Cassady, Cole, Thompson, & Weinberger, 1973;Galambos, Sheatz, & Vernier, 1955;Oleson, Ashe, & Weinberger, 1975) and has been reported as well in olfactory (Freeman, 1980), somatosensory (e.g., Voronin, Gerstein, Kudryashov, & Ioffe, 1975), and visual (e.g., Shinkman, Bruce, & Pfingst, 1974) cortices. Thus, sensory responses are affected by two types of variables: (a) the physical parameters of stimuli and (b) the meaning or cue value of stimuli.…”

mentioning

confidence: 99%

Physiological plasticity of single neurons in auditory cortex of the cat during acquisition of the pupillary conditioned response: I. Primary field (AI).

Weinberger¹,

Hopkins²,

Diamond³

1984

Behavioral Neuroscience

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The effects of conditioning on the discharges of single neurons in primary auditory cortex (AI) were determined during acquisition of the pupillary conditioned response in chronically prepared cats. Acoustic stimuli (1-s white noise or tone) were presented with electrodermal stimulation unpaired during a sensitization control phase followed by pairing during a subsequent conditioning phase. Stimulus constancy at the periphery was ensured by the use of neuromuscular blockade. Discharge plasticity developed rapidly for both evoked and background activity, the former attaining criterion faster than the latter. The pupillary dilation conditioned response was acquired at the same rate as were changes in evoked activity (i.e., 10-15 trials) and faster than background activity (i.e., 20-25 trials). Increases in background activity were correlated with increasing level of tonic arousal, as indexed by pretrial size of the pupil.

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Neural correlates of asymptotic avoidance and classical conditioned leg flexion

Cited by 14 publications

References 5 publications

New perspectives on the auditory cortex

New perspectives on the auditory cortex

Neuronal unit activity in the abducens nucleus during classical conditioning of the nictitating membrane response in the rabbit (Oryctolagus cuniculus).

Physiological plasticity of single neurons in auditory cortex of the cat during acquisition of the pupillary conditioned response: I. Primary field (AI).

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