2003
DOI: 10.1523/jneurosci.23-09-03855.2003
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Neural Correlates of Competing Fear Behaviors Evoked by an Innately Aversive Stimulus

Abstract: Environment and experience influence defensive behaviors, but the neural circuits mediating such effects are not well understood. We describe a new experimental model in which either flight or freezing reactions can be elicited from mice by innately aversive ultrasound. Flight and freezing are negatively correlated, suggesting a competition between fear motor systems. An unfamiliar environment or a previous aversive event, moreover, can alter the balance between these behaviors. To identify potential circuits … Show more

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Cited by 129 publications
(117 citation statements)
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“…5). There was little cat odor-related Fos expression in other septal regions, including the diagonal band of Broca (Mongeau et al, 2003).…”
Section: The Lateral Septummentioning
confidence: 97%
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“…5). There was little cat odor-related Fos expression in other septal regions, including the diagonal band of Broca (Mongeau et al, 2003).…”
Section: The Lateral Septummentioning
confidence: 97%
“…Benzodiazepines injected directly into this region are anxiolytic across a range of animal models (Menard and Treit, 1999), and the lateral septum (ventral part) has been identified as a key region that differentiates active versus passive forms of defense (Mongeau et al, 2003). This area was strongly activated in mice showing freezing rather than fleeing to an anxiogenic ultrasonic stimulus (Mongeau et al, 2003).…”
Section: The Lateral Septummentioning
confidence: 99%
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“…Mice were tested for their innate fear reactions to a train of ultrasonic stimuli (US), as described previously (Mongeau et al, 2003). Animals were placed one per cage for at least 1 week before testing.…”
Section: Behavioral Testingmentioning
confidence: 99%
“…It seems that these two are phenotypically flexible response patterns, for instance in voles (Sundell & Ylönen 2004), and after a correct stimulus interpretation both may be equally effective for survival, depending on type of predator and hunting environment (Eilam et al 1999). An unfamiliar environment or a previous aversive event can, however, alter the balance between these behaviors (Mongeau et al 2003). The intermediate behaviors should be the most ineffective against an approaching predator.…”
Section: Introductionmentioning
confidence: 99%