Neural correlates of electrointestinography: Insular activity modulated by signals recorded from the abdominal surface

Hashimoto, Takanao; Kitajo, Keiichi; Kajihara, Takafumi; Ueno, Kenichi; Suzuki, Chisato; Asamizuya, Takeshi; Iriki, Atsushi

doi:10.1016/j.neuroscience.2014.12.057

Cited by 4 publications

(4 citation statements)

References 45 publications

(50 reference statements)

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“…The fact that a common gastric input reaches these different body maps might facilitate the coordination of the different frames of reference employed in touch, action, and vision, but this hypothesis remains to be experimentally tested. Nevertheless, current results indicate that the stomach, and probably more generally the entire GI tract [93], is coupled with the brain at rest in a novel, delayed-connectivity RSN, cutting across canonical RSNs.…”

Section: Viscera-brain Coupling Reveals New Rsnsmentioning

confidence: 57%

Visceral Signals Shape Brain Dynamics and Cognition

Azzalini

Rebollo

Tallon‐Baudry

2019

Trends in Cognitive Sciences

321

294

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Most research in cognitive neuroscience explores how external stimuli are processed by the brain. However, the brain also receives input from the internal body. We discuss here how the heart and gastrointestinal (GI) tract intrinsically generate their own electrical activity, thereby continuously sending information to the brain. These ongoing ascending signals actively shape brain dynamics at rest, complementing canonical resting-state networks (RSNs). Cardiac signals also influence the processing of external sensory information and the production of spontaneous, internal cognition. These findings are discussed in relation to interpretative frameworks regarding the functional role of visceral inputs. This active field of research offers a unique opportunity to draw new theories blurring the border between cognition, emotion, and consciousness, as well as between mind and body. A Paradigm Shift in Cognitive Neuroscience 'The brain is bombarded by information from the environment.' This sentence, in one form or another, acts as an introduction to many textbooks and articles about perception and cognition (e.g., [1]). Although the internal environment is sometimes mentioned, the vast majority of the experimental work pertains to the processing of external stimuli. This reflects the dominant paradigm in cognitive neuroscience, where an agent collects information from the external environment via the senses and then reacts to this environment by producing actions (Figure 1A). By studying the brain, cognitive neuroscience has been highly successful at providing mechanistic explanations of behavior and at revealing the existence of hidden rules and variables, such as for instance the reward prediction error [2]. In the following we review extensions of this paradigm that include the interplay between the brain and the internal bodily environment (Figure 1B) to account for the neural implementation of cognition. More specifically, we focus on the heart and the gastrointestinal (GI) tract (see Glossary), and refer the reader to [3] for a comprehensive review of other types of somatic influences, including notably humoral and immune factors.

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Section: Viscera-brain Coupling Reveals New Rsnsmentioning

confidence: 57%

Visceral Signals Shape Brain Dynamics and Cognition

Azzalini

Rebollo

Tallon‐Baudry

2019

Trends in Cognitive Sciences

321

294

View full text Add to dashboard Cite

show abstract

“…Additionally, important biological information could be obtained by measuring other gastric parameters beyond electrical activity, such as the pH of the stomach, or the regulation of gastric distention, contractions and size by the autonomic and central nervous system. Similarly, the influence of other gut organs such as the large and small intestine on intrinsic brain activity have remained largely unexplored (but see (44)). Finally, there would be great potential for ambulatory EGG recordings, a method which is still technically challenging but currently in development (45).…”

Section: -Back To the Gutmentioning

confidence: 99%

Brain–stomach coupling: Anatomy, functions, and future avenues of research

Rebollo

Wolpert

Tallon‐Baudry

2021

Current Opinion in Biomedical Engineering

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“…31 However, when the slow wave activity was accompanied by spike bursts, a number of ancillary bands appeared within the upper range of frequency. Again electrointestinographic studies of human subjects 35 identified colonic (6 cpm) and small intestinal (7.8-12 cpm) frequencies within this range. Hence, the activity in the higher frequency range in our studies, which was not an exact multiple of that in the middle range of frequencies and was of much greater standard deviation, could result from a combination of harmonics and extraneous physiological frequencies, notably spike potentials on gastric slow waves or intestinal slow waves, which latter may have been precipitated by distension of the small intestine with digesta emptying from the stomach.…”

Section: Discussionmentioning

confidence: 76%