Neural correlates of emotional processing in panic disorder

Korgaonkar, Mayuresh S.; Tran, Jenny; Felmingham, Kim L.; Williams, Leanne M.; Bryant, Richard A.

doi:10.1016/j.nicl.2021.102902

Cited by 8 publications

(4 citation statements)

References 40 publications

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“…A variety of affective and disorder-relevant experimental tasks have been used in fMRI trials of anxiety disorders with a mixed pattern of results ( Caseras et al, 2010 ; Nakao et al, 2011 ; Giménez et al, 2012 ; Petrowski et al, 2014 ; Schwab et al, 2020 ; Korgaonkar et al, 2021 ). One study in SAD reported increased activation in the bilateral cerebellum and vermis, during a social scrutiny exposure task, but activation in the left cerebellum was also reported in controls ( Giménez et al, 2012 ).…”

Section: Resultsmentioning

confidence: 99%

“…Similarly, Nakao et al (2011) found that both SAD and controls showed cerebellar activation during a social situation task, although controls displayed greater activation in left cerebellum. In PD, relatively decreased activation of the right cerebellum was reported during processing of emotional faces ( Korgaonkar et al, 2021 ). In line with this, another study using a similar task noted decreased activation of the left cerebellum in PD patients with comorbid agoraphobia, relative to controls ( Petrowski et al, 2014 ).…”

Section: Resultsmentioning

confidence: 99%

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Imaging the cerebellum in post-traumatic stress and anxiety disorders: a mini-review

Gil-Paterna,

Furmark

2023

Front. Syst. Neurosci.

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Post-traumatic stress disorder (PTSD) and anxiety disorders are among the most prevalent psychiatric conditions worldwide sharing many clinical manifestations and, most likely, neural mechanisms as suggested by neuroimaging research. While the so-called fear circuitry and traditional limbic structures of the brain, particularly the amygdala, have been extensively studied in sufferers of these disorders, the cerebellum has been relatively underexplored. The aim of this paper was to present a mini-review of functional (task-activity or resting-state connectivity) and structural (gray matter volume) results on the cerebellum as reported in magnetic resonance imaging studies of patients with PTSD or anxiety disorders (49 selected studies in 1,494 patients). While mixed results were noted overall, e.g., regarding the direction of effects and anatomical localization, cerebellar structures like the vermis seem to be highly involved. Still, the neurofunctional and structural alterations reported for the cerebellum in excessive anxiety and trauma are complex, and in need of further evaluation.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Imaging the cerebellum in post-traumatic stress and anxiety disorders: a mini-review

Gil-Paterna,

Furmark

2023

Front. Syst. Neurosci.

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“…Given that the pgACC, one important node in the salience network, plays a pivotal role in emotion processing, especially emotion regulation and emotional conflicts, and anxiety (Egner et al ., 2008 ; Hakamata et al ., 2017 ; Korgaonkar et al ., 2021 ), it is not surprising that the coupling of right SFA and pgACC was negatively associated with childhood trauma, in particular with physical neglect. One previous study on bipolar disorder supported that the functional connectivity between the ventromedial prefrontal cortex (vmPFC, which includes the pgACC) and the limbic system (amygdala and hippocampus) was negatively associated with emotional and physical neglect (Souza-Queiroz et al ., 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Regional superficial amygdala resting-state functional connectivity in adults infers childhood maltreatment severity

et al. 2023

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Background Childhood maltreatment is a potential risk factor for some neuropsychiatric disorders in adulthood (e.g. depression and anxiety) and alters trajectories of brain development. Accumulating evidence suggests that functional connectivity of the limbic system, especially the amygdala, is highly associated with childhood maltreatment, although not all studies have found this. These inconsistent results may be due to differential alterations of amygdala resting-state functional connectivity (rsFC) following childhood maltreatment. Methods In this study, we employed the Childhood Trauma Questionnaire (CTQ) to assess childhood maltreatment severity in each individual. We explored the relationship between the rsFC of amygdala subregions (i.e. centromedial -CMA, basolateral -BLA, superficial-SFA amygdala) and CM experience in a discovery dataset of n = 110 healthy Chinese participants by linear multiple regression analysis. Subsequent dimensional and categorical approach were performed to elucidate the relationship between rsFCs and CM severity and CM subtypes, respectively. A support vector regression model was then conducted to validate the associations between rsFCs and total CTQ scores. Moreover, we also verified the model into another independent replication dataset (n = 38). Results Our findings suggested that childhood maltreatment was negatively associated with rsFC between the right superficial amygdala and perigenual anterior cingulate cortex (pgACC)/postcentral gyrus (PCG) but not the other two amygdala subregions. Moreover, SFA-pgACC coupling was more associated with physical neglect whereas the SFA-PCG was more related to emotional neglect. In addition, supervised machine learning confirmed that using these two rsFCs as predictors could stably estimate continuous maltreatment severity in both discovery and replication datasets. Conclusion The current study supports that the rsFCs of superficial amygdala are related to childhood maltreatment and which may be a potential biomarker for the effects of childhood maltreatment-related psychiatric disorders (i.e. depression and anxiety).

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“…Um den Grad und die Art der Alexithymie zu bestimmen, wurde die inzwischen weltweit eingesetzte Toronto Alexithymia Scale entwickelt.Emotionale Abweichungen vom so genannten ‚Normalzustand' gehören folglich zum Alltag in der Psychiatrie und finden sich bei vielen Störungsbildern. Beispiele sind Patienten mit Panikstörungen(Korgaonkar et al 2021), Zwangsstörungen(Lazarov et al 2022), Angsterkrankungen (Parikh, de Brigard, La Bar 2022), Posttraumatischen Belastungsstörungen (Ogłodek 2022), Bulimie, Borderline-Persönlichkeitsstörung (Dodd et al 2022) oder mit Schizophrenie (Garcia-Leon et al 2021). Im Folgenden gehe ich nun näher auf ein Krankheitsbild ein (Dissoziative Amnesie), die ein ideales Beispiel für eine Hypokognition von Emotionen beschreibt.…”

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Hypokognition der Emotion aus neurowissenschaftlicher Perspektive

Markowitsch¹

2023

Anthropologie Der Emotionen

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Neural correlates of emotional processing in panic disorder

Cited by 8 publications

References 40 publications

Imaging the cerebellum in post-traumatic stress and anxiety disorders: a mini-review

Imaging the cerebellum in post-traumatic stress and anxiety disorders: a mini-review

Regional superficial amygdala resting-state functional connectivity in adults infers childhood maltreatment severity

Hypokognition der Emotion aus neurowissenschaftlicher Perspektive

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