Neural Correlates of Sensorineural Hearing Loss

Salvi, Richard; Henderson, D.; Hamernik, Roger P.; Ahroon, William A.

doi:10.1097/00003446-198305000-00001

Cited by 35 publications

(17 citation statements)

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“…The intercept decreased with hearing threshold, representing a shift along the signal level axis, and the linear term increased proportionally with animals' PTAs, indicating that the greater the hearing loss the steeper the N-level functions. A steeper slope is consistent with some reports on the input-output function of the amplitude of the N1 of the CAP in noise-exposed animals ͑Elberling and Salomon, 1976; Salvi et al, 1983;Wang and Dallos, 1972͒ and humans with sensorineural hearing loss ͑Yoshie and Ohashi, 1969;Portmann et al, 1973͒. However, these reports are by no means conclusive, as other investigators reported no change in the slope or a decrease in the slope in the N1-amplitude functions ͑Popelar et al., 1987;Dolan and Mills, 1989͒. The increase in the slope of the high frequency ͑i.e., 8 and 16 kHz͒ N-level functions in hearing-impaired animals suggests a recruitmentlike phenomenon.…”

Section: B Parameter Nsupporting

confidence: 88%

“…One problem with this type of hearing loss is that damage to the cochlea and auditory nerve varies greatly among patients ͑Schuknecht, 1988͒, and clinical techniques that distinguish and quantify the anatomical changes are lacking. Although audiometric threshold measurements are clinically valuable, they fail to provide sufficient information regarding underlying cochlear pathologies and neural integrity ͑e.g., see Salvi et al, 1983͒. New techniques that distinguish sensory from neural pathologies and that also estimate the extent of anatomical damage would be useful in the clinical setting to provide a site of lesion as hair cell regeneration and genetic therapy are developed and may perhaps drive advancements in signal processing of hearing aids and cochlear implants.…”

Section: Introductionmentioning

confidence: 99%

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The influence of noise exposure on the parameters of a convolution model of the compound action potential

Chertoff

Lichtenhan

Tourtillott

et al. 2008

The Journal of the Acoustical Society of America

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The influence of noise exposure on the parameters of a convolution model of the compound action potential ͑CAP͒ was examined. CAPs were recorded in normal-hearing gerbils and in gerbils exposed to a 117 dB SPL 8 kHz band of noise for various durations. The CAPs were fitted with an analytic CAP to obtain the parameters representing the number of nerve fibers ͑N͒, the probability density function ͓P͑t͔͒ from a population of nerve fibers, and the single-unit waveform ͓U͑t͔͒. The results showed that the analytic CAP fitted the physiologic CAPs well with correlations of approximately 0.90. A subsequent analysis using hierarchical linear modeling quantified the change in the parameters as a function of both signal level and hearing threshold. The results showed that noise exposure caused some of the parameter-level functions to simply shift along the signal level axis in proportion to the amount of hearing loss, whereas others shifted along the signal level axis and steepened. Significant changes occurred in the U͑t͒ parameters, but they were not related to hearing threshold. These results suggest that noise exposure alters the physiology underlying the CAP, some of which can be explained by a simple lack of gain, whereas others may not.

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Section: B Parameter Nsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

The influence of noise exposure on the parameters of a convolution model of the compound action potential

Chertoff

Lichtenhan

Tourtillott

et al. 2008

The Journal of the Acoustical Society of America

View full text Add to dashboard Cite

show abstract

“…By contrast, the spontaneous rate distributions in mammals are typically bimodal with one peak near zero, a gap in the distribution near 20 spikes/s and a second peak around 40-60spikes/s (Liberman 1978;Salvi et al 1983). A bimodal distribution has also been seen in caiman (Klinke and Pause 1980).…”

Section: Spontaneous Activitymentioning

confidence: 99%

Discharge patterns of cochlear ganglion neurons in the chicken

et al. 1992

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Physiological recordings were made of the compound action potential from the round window and single neurons in the cochlear ganglion of normal adult chickens (Gallus domesticus). The compound action potential threshold to tone bursts decreased from approximately 42 dB at 0.25 kHz to 30 dB between 1 and 2 kHz and then increased to 51 dB at 4 kHz. Most of the cochlear ganglion cells had characteristic frequencies below 2 kHz and the thresholds of most neurons were roughly 30-35 dB lower than the compound action potential thresholds. At any given characteristic frequency, thresholds varied by as much as 60 dB and units with the highest thresholds tended to have the lowest spontaneous rates. Spontaneous discharge rates ranged from 0 to 200 spikes/s with a mean rage of 86 spikes/s. Interspike interval histograms of spontaneous activity often contained regular peaks with the time interval between peaks approximately equal to 1/(characteristic frequency). Tuning curves were sharply tuned and V-shaped with approximately equal slopes to the curves above and below characteristic frequency. Q10dB and Q30dB values for the tuning curves increased with characteristic frequency. Post stimulus time histograms showed sustained firing during the stimulus and were characterized by a slight-to-moderate peak at stimulus onset. Most units showed vigorous phase-locking to tones at characteristic frequency although the degree of phase-locking declined sharply with increasing characteristic frequency. Discharge rate-level functions at characteristic frequency had a mean dynamic range of 42 dB and a mean saturation firing rate of 327 spikes/s. In general, the firing patterns of cochlear ganglion neurons are similar in most respects to those reported in other avians, but differ in several important respects from those seen in mammals.

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“…Studies report that 5-15% of the western populations experience a form of tinnitus requiring medical intervention with 1-2% experiencing significant impairments in their quality of life (QoL) 7 . Researchers have suggested that the quality of life of patients is reduced as a result of the severe distress of tinnitus 8,9 with depression and anxiety being reported to be the commonest psychological comorbidities suffered by these patients 10,11 . The relationship between tinnitus and these comorbidities is complex and poorly understood and the lack of coping capabilities can play a critical role in the clinical history of severe tinnitus sufferers 12 .…”

Section: Introductionmentioning

confidence: 99%