Neural correlates of the individual emotional Stroop in borderline personality disorder

Wingenfeld, Katja; Rullkoetter, Nina; Mensebach, Christoph; Beblo, Thomas; Mertens, Markus; Kreisel, Stefan H.; Toepper, Max; Drießen, Martin; Woermann, Friedrich G.

doi:10.1016/j.psyneuen.2008.10.024

Cited by 100 publications

(113 citation statements)

References 90 publications

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“…This result suggests that the lObfc volume is associated with the capacity to regulate emotional processes. lObfc is involved in complex emotional regulation such as cognitive reappraisal of emotional stimuli (Eippert et al, 2007;Wager et al, 2008;Kanske et al, 2011;Golkar et al, 2012) and it has been suggested that it has critical role in psychiatric disorders displaying emotional dysregulation (Castellanos and Tannock, 2002;Lieb et al, 2004;Yang and Raine, 2009;Soloff et al, 2012) mirrored in lower functional activations in emotional regulation tasks (Wingenfeld et al, 2009;Yang and Raine, 2009;Schulze et al, 2011) and a smaller GMV (Yang and Raine, 2009;Soloff et al, 2012). Importantly, subjects in our studies were mentally healthy (see Materials and Methods and Figure 1).…”

Section: Discussionmentioning

confidence: 70%

“…For example, in ADHD, smaller GMV in dlPFC and cACC has been observed (Seidman et al, 2011), and these structures are less activated during attentional tasks in this group (Dickstein et al, 2006). Likewise, in BPD, smaller GMV has been observed in lObfc and rACC (Soloff et al, 2008(Soloff et al, , 2012 and these regions are less activated in emotional regulation for this group of patients (Wingenfeld et al, 2009;Schulze et al, 2011). At the same time, BPD is linked to smaller volume in insula and amygdala (Soloff et al, 2008(Soloff et al, , 2012 but an over-activity of these regions in emotional processes (Herpertz et al, 2001;Donegan et al, 2003;Hazlett et al, 2012)-possibly suggesting a reduced volume in local inhibitory networks.…”

Section: Discussionmentioning

confidence: 75%

“…It has been suggested that these regions have a critical role in psychiatric disorders displaying emotional dysregulation including BPD, APD and emotional ADHD (Castellanos and Tannock, 2002;Lieb et al, 2004;Yang and Raine, 2009;Soloff et al, 2012). Apart from lower functional activations in emotional regulation tasks (Wingenfeld et al, 2009;Yang and Raine, 2009;Schulze et al, 2011), volumetric studies have found reduced brain volume in rACC and lObfc (Soloff et al, 2008(Soloff et al, , 2012Yang and Raine, 2009) for these disorders.…”

Section: Introductionmentioning

confidence: 99%

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Significant grey matter changes in a region of the orbitofrontal cortex in healthy participants predicts emotional dysregulation

Petrović

Ekman

Klahr

et al. 2015

Social Cognitive and Affective Neuroscience

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The traditional concept of 'categorical' psychiatric disorders has been challenged as many of the symptoms display a continuous distribution in the general population. We suggest that this is the case for emotional dysregulation, a key component in several categorical psychiatric disorder constructs. We used voxel-based magnetic resonance imaging morphometry in healthy human subjects (n ¼ 87) to study how self-reported subclinical symptoms associated with emotional dysregulation relate to brain regions assumed to be critical for emotion regulation. To measure a pure emotional dysregulation, we also corrected for subclinical symptoms of non-emotional attentional dysregulation. We show that such subclinical emotional symptoms correlate negatively with the grey matter volume of lateral orbitofrontal cortex bilaterally-a region assumed to be critical for emotion regulation and dysfunctional in psychiatric disorders involving emotional dysregulation. Importantly, this effect is mediated both by a decrease in volume associated with emotional dysregulation and an increase in volume due to non-emotional attentional dysregulation. Exploratory analysis suggests that other regions involved in emotional processing such as insula and ventral striatum also show a similar reduction in grey matter volume mirroring clinical disorders associated with emotional dysregulation. Our findings support the concept of continuous properties in psychiatric symptomatology.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 99%

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Significant grey matter changes in a region of the orbitofrontal cortex in healthy participants predicts emotional dysregulation

Petrović

Ekman

Klahr

et al. 2015

Social Cognitive and Affective Neuroscience

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“…For instance, some studies have shown decreased resting-state blood flow in right temporal regions 6 and decreased activation of the temporal cortex during response inhibition. 50 In contrast, increased activation of middle and inferior temporal areas has been described during tasks requiring emotional processing. 51 With regard to parietal regions, neuropsychologic studies have suggested visuospatial processing and learning deficits in patients with BPD, 52 possibly linked to an impaired engagement of prefrontal and posterior parietal attentional systems.…”

Section: Discussionmentioning

confidence: 99%

Aberrant connectivity of resting-state networks in borderline personality disorder

Wolf

Sambataro

Vasić

et al. 2011

jpn

109

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Background: Several functional neuroimaging studies have reported regionally abnormal activation of the frontal cortex in individuals with borderline personality disorder (BPD) during cognitive and affective task performance. However, little is known about neural function in individuals with BPD during the resting state. Using functional magnetic resonance imaging (fMRI), this study investigated the functional connectivity of prefrontal and limbic networks in patients with BPD. Methods: Between January 2009 and March 2010, we investigated patients with BPD according to DSM-IV criteria and healthy controls by means of resting-state fMRI. The data were analyzed using a spatial group independent component analysis, and random effects t tests were used to compare spatial components between groups (p < 0.005, uncorrected). Results: There were 17 women with BPD and 17 female healthy controls enrolled in this study. Within a network comprising cortical midline regions ("default mode network"), patients with BPD showed an increase in functional connectivity in the left frontopolar cortex (FPC) and the left insula, whereas decreased connectivity was found in the left cuneus. Within a network comprising predominantly right lateral prefrontal and bilateral parietal regions, patients with BPD showed decreased connectivity of the left inferior parietal lobule and the right middle temporal cortex compared with healthy controls. Two networks comprising lateral prefrontal and cingulate regions did not exhibit significant between-group differences. We found correlations between functional connectivity of the FPC and measures of impulsivity as well as between connectivity of the insula/cuneus and dissociation tension. Limitations: Co-occurrent axis I disorders and medication use in this sample of patients with BPD have to be considered as potential limitations. Conclusion: These data suggest that abnormal functional connectivity of temporally coherent resting-state networks may underlie certain symptom clusters in patients with BPD

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“…In order to directly assess the potential role that failures in response inhibition may play in BPD, Wingenfeld and colleagues [156] administered the emotional Stroop task and compared performance on the task between a sample of 20 individuals with BPD and 20 HCs while they underwent fMRI. In the emotional Stroop task, 12 words are presented (4 of each type: neutral, generally negative words, negative words specific to each participant, meaningless sequence of letters) in four colors and the participant has to correctly name the color that the word (or letters) is presented in.…”

Section: Neural Network Impulsivity and Bpdmentioning

confidence: 99%

Using Functional Neuroimaging to Refine the Diagnostic Construct of Borderline Personality Disorder

Silverman¹,

Schulz²,

Cullen³

2016

J Neuroimaging Psychiatry Neurol

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Neural correlates of the individual emotional Stroop in borderline personality disorder

Cited by 100 publications

References 90 publications

Significant grey matter changes in a region of the orbitofrontal cortex in healthy participants predicts emotional dysregulation

Significant grey matter changes in a region of the orbitofrontal cortex in healthy participants predicts emotional dysregulation

Aberrant connectivity of resting-state networks in borderline personality disorder

Using Functional Neuroimaging to Refine the Diagnostic Construct of Borderline Personality Disorder

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