Neural correlates of voluntary and involuntary risk taking in the human brain: An fMRI Study of the Balloon Analog Risk Task (BART)

Rao, Hengyi; Korczykowski, Marc; Pluta, John; Hoang, Angela; Detre, John A.

doi:10.1016/j.neuroimage.2008.05.046

Cited by 314 publications

(348 citation statements)

References 52 publications

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“…The advantage of this design is that rewards and losses are thought to be more meaningful when there is an active choice to play (Rao et al, 2008;Tricomi et al, 2004). Therefore, the analyses were focused on the brain responses to reward and loss following play trials.…”

Section: Discussionmentioning

confidence: 99%

“…To these ends, we report two experiments using a risky decision task, in which participants could choose to take a gamble (and win or lose 10 Eurocents) or pass on this gamble (in which case nothing was gained or lost). We were specifically interested in the brain's response to rewards and losses as a result of an active gamble, since prior studies have shown that outcome monitoring is more salient when the outcomes are the result of an active choice (Rao, Korczykowski, Pluta, Hoang, & Detre, 2008;Tricomi, Delgado, & Fiez, 2004).…”

Section: Introductionmentioning

confidence: 99%

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A cross-sectional and longitudinal analysis of reward-related brain activation: Effects of age, pubertal stage, and reward sensitivity

Duijvenvoorde

Macks

Overgaauw

et al. 2014

Brain and Cognition

109

102

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Neurobiological models suggest that adolescents are driven by an overactive ventral striatum (VS) response to rewards that may lead to an adolescent increase in risk-taking behavior. However, empirical studies showed mixed findings of adolescents' brain response to rewards. In this study, we aimed to elucidate the relationship between reward-related brain activation and risky decision-making. In addition, we examined effects of age, puberty, and individuals' reward sensitivity. We collected two datasets: Experiment 1 reports cross-sectional brain data from 75 participants (ages 10-25) who played a risky decision task. Experiment 2 presents a longitudinal extension in which a subset of these adolescents (n = 33) was measured again 2 years later. Results showed that (1) a reward-related network including VS and medial PFC was consistently activated over time, (2) the propensity to choose the risky option was related to increased reward-related activation in VS and medial PFC, and (3) longitudinal comparisons indicated that self-reported reward sensitivity was specifically related to VS activation over time. Together, these results advance our insights in the brain circuitry underlying reward processing across adolescence.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A cross-sectional and longitudinal analysis of reward-related brain activation: Effects of age, pubertal stage, and reward sensitivity

Duijvenvoorde

Macks

Overgaauw

et al. 2014

Brain and Cognition

109

102

View full text Add to dashboard Cite

show abstract

“…This analysis targeted the right middle frontal gyrus, which was associated with parametric modulation of activation with striatal D2-like receptor availability in our prior published findings (Kohno et al, 2013). The right middle frontal gyrus was sampled as a spherical ROI with a 10-mm radius around the peak voxel (MNI coordinates: x = 30, y = 36, z = 20) from a cluster previously associated with risk-taking on the BART (Rao et al, 2008). We examined the relationship between the modulation of activation by risk in this region of interest with all other possible scores derived from variants in the five genes considered.…”

Section: Iterative Permutation Modelmentioning

confidence: 99%

Functional Genetic Variation in Dopamine Signaling Moderates Prefrontal Cortical Activity During Risky Decision Making

Kohno

Nurmi

Laughlin

et al. 2015

Neuropsychopharmacol

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Brain imaging has revealed links between prefrontal activity during risky decision-making and striatal dopamine receptors. Specifically, striatal dopamine D2-like receptor availability is correlated with risk-taking behavior and sensitivity of prefrontal activation to risk in the Balloon Analogue Risk Task (BART). The extent to which these associations, involving a single neurochemical measure, reflect more general effects of dopaminergic functioning on risky decision making, however, is unknown. Here, 65 healthy participants provided genotypes and performed the BART during functional magnetic resonance imaging. For each participant, dopamine function was assessed using a gene composite score combining known functional variation across five genes involved in dopaminergic signaling: DRD2, DRD3, DRD4, DAT1, and COMT. The gene composite score was negatively related to dorsolateral prefrontal cortical function during risky decision making, and nonlinearly related to earnings on the task. Iterative permutations of all possible allelic variations (7777 allelic combinations) was tested on brain function in an independently defined region of the prefrontal cortex and confirmed empirical validity of the composite score, which yielded stronger association than 95% of all other possible combinations. The gene composite score also accounted for a greater proportion of variability in neural and behavioral measures than the independent effects of each gene variant, indicating that the combined effects of functional dopamine pathway genes can provide a robust assessment, presumably reflecting the cumulative and potentially interactive effects on brain function. Our findings support the view that the links between dopaminergic signaling, prefrontal function, and decision making vary as a function of dopamine signaling capacity.

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“…However, the neural data show significantly higher activation in the left and right medial prefrontal cortices when approaching a yellow light when the participants drove with a passenger. Studies have shown these areas to be associated with active risky decision-making (Rao et al, 2008), voluntary decision-making (Cazzell et al, 2012), and response inhibition (Rubia et al, 2003). Thus, despite no outward (simulator-measured) behavioral evidence of specific driving decisions, the data suggest active differences in neural processing during these scenarios.…”

Section: Resultsmentioning

confidence: 82%

Pre-Frontal Cortex Activity of Male Drivers in the Presence of Passengers During Simulated Driving: An Exploratory Functional Near- Infrared Spectroscopy (fNIRS) Study

Pradhan

Buckley

et al. 2015

Proceedings of the 8th International Driving Symposium on Human Factors in Driver Assessment, Training, and Vehicle Design: Dri

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Neural correlates of voluntary and involuntary risk taking in the human brain: An fMRI Study of the Balloon Analog Risk Task (BART)

Cited by 314 publications

References 52 publications

A cross-sectional and longitudinal analysis of reward-related brain activation: Effects of age, pubertal stage, and reward sensitivity

A cross-sectional and longitudinal analysis of reward-related brain activation: Effects of age, pubertal stage, and reward sensitivity

Functional Genetic Variation in Dopamine Signaling Moderates Prefrontal Cortical Activity During Risky Decision Making

Pre-Frontal Cortex Activity of Male Drivers in the Presence of Passengers During Simulated Driving: An Exploratory Functional Near- Infrared Spectroscopy (fNIRS) Study

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