Neural Effects of Nitrofurantoin

Toole, James F.; Gergen, John A.; Hayes, D. S.; Felts, John H.

doi:10.1001/archneur.1968.00470360102010

Cited by 22 publications

(2 citation statements)

References 25 publications

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“…Diminished excretion of nitrofurantoin in renal failure presumably results in high tissue drug levels, which in turn lead to axonal degeneration of peripheral nerve and sensory roots [40].…”

Section: Peripheral Nervous System Toxicitymentioning

confidence: 99%

Mechanisms of antibiotic neurotoxicity in renal failure

Chow

Szeto

Hui

et al. 2004

International Journal of Antimicrobial Agents

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Section: Peripheral Nervous System Toxicitymentioning

confidence: 99%

Mechanisms of antibiotic neurotoxicity in renal failure

Chow

Szeto

Hui

et al. 2004

International Journal of Antimicrobial Agents

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“…Under aerobic conditions, the reduction of nitrofurantoin by the addition of an electron to the 5nitrofuran ring via a nitroreductase, NADPH, and a flavoprotein has been reported to occur in vitro in hepatic and/or lung microsomes from rats (male, CD, 160-180 g. Mason and Holtzman, 1975a; male, HLA-SD, 150 g, Boyd et al, 1979a; male, Sprague Dawley, [135][136][137][138][139][140]…”

Section: Absorption Metabolism and Excretionmentioning

confidence: 99%

NTP technical report on the toxicology and carcinogenesis studies of nitrofurantoin (CAS no. 67-20-9) in F344/N rats and B6C3F mice (feed studies) / National Toxicology Program.

1989

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Nitrofurantoin was studied and evaluated because of its widespread use as a drug for treating urinary tract infections in humans, its structural relationship to known carcinogenic 5-nitrofuran compounds, and the lack of adequate studies to assess its carcinogenicity Toxicology and carcinogenesis studies of nitrofurantoin were conducted by administering nitrofurantoin (greater than 99% pure) in feed to groups of F344/N rats and B6C3Fi mice of each sex for 14 days, 13 weeks, or 2 years. Fourteen-Day and Thirteen-Week Studies: None of the rats (at dietary concentrations up to 20,000 ppm) died before the end of the 14-day studies. Rats that received 5,000, 10,000, or 20,000 ppm lost weight. Four of five male and 4/5 female mice that received 10,000 ppm and 1/5 females that received 5,000 ppm nitrofurantoin died before the end of the studies. Mice that received 5,000 ppm and male mice that received 10,000 ppm lost weight. In the 13-week studies, final mean body weights of rats that received 2,500, 5,000, or 10,000 ppm were 10%, 34%, or 47% lower than that of the controls for males and 15%, 31%, or 41% lower for females. Feed consumption by dosed and control rats was generally similar. Degeneration of the germinal epithelium of the seminiferous tubules of the testis was observed in male rats that received 2,500 to 10,000 ppm nitrofurantoin. Necrosis of the ovarian follicles was observed in 8/10 female rats that received 10,000 ppm, in 3/10 females that received 5,000 ppm, and in 1/10 that received 2,500 ppm. For mice, final mean body weights of the 5,000-ppm groups were 13% lower than that of the controls for males and 15% lower for females. Two of 10 male mice that received 5,000 ppm and 1/10 males that received 300 ppm died before the end of the 13-week studies. Estimated feed consumption was similar for dosed and control groups. Degeneration of the germinal epithelium of the testis was observed in males that received 1,300 to 5,000 ppm; necrosis of the ovarian follicles was observed in females that received 5,000 ppm but not in the lower dose groups. Necrosis of the renal tubular epithelium was observed in 2/9 males that received 5,000 ppm. Based on these results, 2-year studies of nitrofurantoin were conducted by feeding diets containing 0, 1,300, or 2,500 ppm nitrofurantoin to groups of 50 male F344/N rats and to groups of 50 male and Nitrofurantoin, NTP TR 341 PEER REVIEW PANEL The members of the Peer Review Panel who evaluated the draft Technical Report on nitrofurantoin on July 14, 1987, and on April 18, 1988, are listed below. Panel members serve as independent scientists, not as representatives of any institution, company, or governmental agency. In this capacity, Panel members have five major responsibilities: (a) to ascertain that all relevant literature data have been adequately cited and interpreted, (b) to determine if the design and conditions of the NTP studies were appropriate, (c) to ensure that the Technical Report presents the experimental results and conclusions fully and clearly, (d) to judge the...

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Cerebellar Toxic Effects From Nitrofurantoin

Graebner¹,

Herskowitz²

1973

Archives of Neurology

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Neural Effects of Nitrofurantoin

Cited by 22 publications

References 25 publications

Mechanisms of antibiotic neurotoxicity in renal failure

Mechanisms of antibiotic neurotoxicity in renal failure

NTP technical report on the toxicology and carcinogenesis studies of nitrofurantoin (CAS no. 67-20-9) in F344/N rats and B6C3F mice (feed studies) / National Toxicology Program.

Cerebellar Toxic Effects From Nitrofurantoin

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