1989
DOI: 10.5962/bhl.title.4012
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NTP technical report on the toxicology and carcinogenesis studies of nitrofurantoin (CAS no. 67-20-9) in F344/N rats and B6C3F mice (feed studies) / National Toxicology Program.

Abstract: Nitrofurantoin was studied and evaluated because of its widespread use as a drug for treating urinary tract infections in humans, its structural relationship to known carcinogenic 5-nitrofuran compounds, and the lack of adequate studies to assess its carcinogenicity Toxicology and carcinogenesis studies of nitrofurantoin were conducted by administering nitrofurantoin (greater than 99% pure) in feed to groups of F344/N rats and B6C3Fi mice of each sex for 14 days, 13 weeks, or 2 years. Fourteen-Day and Thirteen… Show more

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