Recent progress in neural information retrieval has demonstrated large gains in effectiveness, while often sacrificing the efficiency and interpretability of the neural model compared to classical approaches. This paper proposes ColBERTer, a neural retrieval model using contextualized late interaction (ColBERT) with enhanced reduction. Along the effectiveness Pareto frontier, ColBERTer's reductions dramatically lower ColBERT's storage requirements while simultaneously improving the interpretability of its token-matching scores. To this end, ColBERTer fuses single-vector retrieval, multivector refinement, and optional lexical matching components into one model. For its multi-vector component, ColBERTer reduces the number of stored vectors per document by learning unique whole-word representations for the terms in each document and learning to identify and remove word representations that are not essential to effective scoring. We employ an explicit multi-task, multi-stage training to facilitate using very small vector dimensions. Results on the MS MARCO and TREC-DL collection show that ColBERTer can reduce the storage footprint by up to 2.5×, while maintaining effectiveness. With just one dimension per token in its smallest setting, ColBERTer achieves index storage parity with the plaintext size, with very strong effectiveness results. Finally, we demonstrate ColBERTer's robustness on seven high-quality outof-domain collections, yielding statistically significant gains over traditional retrieval baselines.does doxycycline contain sulfa BERT tokenized (9 subword-tokens): 'does', 'do', '##xy', '##cy', '##cl', '##ine', 'contain', 'sul', '##fa'ColBERTer BOW 2 (30 saved vectors from 84 subword-tokens): photosensitivity doxycycline 12.9 sulfa 14.2 sunburned rash clothing sunlight allergic compound drugs containing 6.6 take safely wear . is no 4.7 exposed ... Fulltext: No doxycycline is not a sulfa containing compound, so you may take it safely if you are allergic to sulfa drugs. You should be aware, however, that doxycycline may cause photosensitivity, so you should wear appropriate clothing, or you may get easily sunburned or develop a rash if you are exposed to sunlight.