Neural Stem Cells Reduce Brain Injury After Unilateral Carotid Ligation

Comi, Anne M.; Cho, Eunpi; Mulholland, Justin D.; Hooper, Andrew; Li, Qun; Qu, Yun; Gary, Devin S.; McDonald, John W.; Johnston, Michael V.

doi:10.1016/j.pediatrneurol.2007.10.007

Cited by 31 publications

(36 citation statements)

References 24 publications

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“…Newborn neu-rons integrate into existing circuits and could contribute to recovery from injury. In addition to their potential role in replacing damaged neurons, newborn stem cells have been shown to have a protective effect when injected within days after injury, possibly by expressing growth factors [Comi et al, 2008].…”

Section: Mechanisms For Plasticity In the Central Nervous Systemmentioning

confidence: 99%

Plasticity in the developing brain: Implications for rehabilitation

Johnston

2009

Dev Disabil Res Revs

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443

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Neuronal plasticity allows the central nervous system to learn skills and remember information, to reorganize neuronal networks in response to environmental stimulation, and to recover from brain and spinal cord injuries. Neuronal plasticity is enhanced in the developing brain and it is usually adaptive and beneficial but can also be maladaptive and responsible for neurological disorders in some situations. Basic mechanisms that are involved in plasticity include neurogenesis, programmed cell death, and activity-dependent synaptic plasticity. Repetitive stimulation of synapses can cause long-term potentiation or long-term depression of neurotransmission. These changes are associated with physical changes in dendritic spines and neuronal circuits. Overproduction of synapses during postnatal development in children contributes to enhanced plasticity by providing an excess of synapses that are pruned during early adolescence. Clinical examples of adaptive neuronal plasticity include reorganization of cortical maps of the fingers in response to practice playing a stringed instrument and constraint-induced movement therapy to improve hemiparesis caused by stroke or cerebral palsy. These forms of plasticity are associated with structural and functional changes in the brain that can be detected with magnetic resonance imaging, positron emission tomography, or transcranial magnetic stimulation (TMS). TMS and other forms of brain stimulation are also being used experimentally to enhance brain plasticity and recovery of function. Plasticity is also influenced by genetic factors such as mutations in brain-derived neuronal growth factor. Understanding brain plasticity provides a basis for developing better therapies to improve outcome from acquired brain injuries. ' 2009 Wiley-Liss, Inc. Dev Disabil Res Rev 200915:94-101.

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Section: Mechanisms For Plasticity In the Central Nervous Systemmentioning

confidence: 99%

Plasticity in the developing brain: Implications for rehabilitation

Johnston

2009

Dev Disabil Res Revs

Self Cite

443

273

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“…Beneficial effects of cell-based therapies have been noted with stem cell transplantation in the first hours to 7 days after brain injury [4,5,6,7,45,46]. In a neonatal mouse stroke model, intrastriatal injection of neural stem cells at 2 days but not at 7 days after injury significantly reduced ischemia-induced brain atrophy [47]. In a well-designed dose ranging and timing study in newborn mice, intranasal stem cell transplantation at 3 and 10 days, but not at 17 days, after hypoxic-ischemic brain injury improved outcomes [42].…”

Section: Determining the Optimal Timing For Msc Transplantationmentioning

confidence: 99%

Stem Cells for Neonatal Brain Disorders

2016

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Despite recent advances in neonatal intensive care medicine, neonatal brain injury resulting from intraventricular hemorrhage or hypoxic-ischemic encephalopathy remains a major cause of neonatal mortality and neurologic morbidities in survivors. Several studies have indicated that stem cell therapy is a promising novel therapy for neonatal brain injury resulting from these disorders. This review summarizes recent advances in stem cell research for treating neonatal brain injury due to intraventricular hemorrhage or hypoxic-ischemic encephalopathy with a particular focus on preclinical data, covering important issues for clinical translation such as optimal cell type, route, dose and timing of stem cell therapy, and translation of these preclinical results into a clinical trial.

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“…The vast majority of those studies have used rodent models of neonatal HIE. Only four studies in rodent models of neonatal stroke have been published [16][17][18][19] (Table 17.2). No study on the effects of cell-based therapy for perinatal/neonatal brain injury in large animal models has been reported, although some groups are doing research on it (abstracts of conferences and personal communications).…”

Section: Overviewmentioning

confidence: 99%

“…Comi et al reported the effects of stem-cell-based therapy in a neonatal stroke model for the first time [16]. They used P12 CD1 mice with permanent unilateral CCAO.…”

Section: Studies In Neonatal Stoke Models: Four Reportsmentioning

confidence: 99%

“…Van Velthoven and colleagues demonstrated that MSC treatment at either 3 days or 10 days, but not 17 days, after HI insult is similarly beneficial [14,44,46,47]. Comi et al reported NSC transplantation at 2 days, but not 7 days, after CCAO is beneficial [16]. Two studies in an excitotoxicity model showed no time-dependent effects comparing 4 h versus 72 h after insult [66] and immediate versus 24 h after insult [67].…”

Section: Cell Typementioning

confidence: 99%

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