Neural Substrates of Cognitive Load Changes During a Motor Task in Subjects with Stroke

Kimberley, Teresa Jacobson; Lewis, Scott M.; Strand, Carolyn A.; Rice, Brooke Darst; Hall, Sara M.; Slivnik, Patricia

doi:10.1097/npt.0b013e318183d716

Cited by 10 publications

(9 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is of particular importance as previous studies have largely failed to demonstrate decisive changes in precision grip following specific rehabilitation procedures, although patients often report a subjective improvement of their ability to conduct daily-life activities involving the manipulation of objects [26]. Therefore, it would be of interest to examine whether these rehabilitation procedures reduce the impact of a concurrent cognitive task on precision grip, which would suggest that the rehabilitation reduced the amount of cognitive resources required for object manipulation [20,45]. In other words, studying precision grip in the context of a concurrent cognitive task may constitute a more ecological way to study motor function, which could be especially useful for the clinical evaluation of patients and the assessment of treatment efficacy.…”

Section: Discussionmentioning

confidence: 99%

Cognitive-Motor Interference While Grasping, Lifting and Holding Objects

2013

View full text Add to dashboard Cite

In daily life, object manipulation is usually performed concurrently to the execution of cognitive tasks. The aim of the present study was to determine which aspects of precision grip require cognitive resources using a motor-cognitive dual-task paradigm. Eighteen healthy participants took part in the experiment, which comprised two conditions. In the first condition, participants performed a motor task without any concomitant cognitive task. They were instructed to grip, lift and hold an apparatus incorporating strain gauges allowing a continuous measurement of the force perpendicular to each contact surface (grip force, GF) as well as the total tangential force applied on the object (load force, LF). In the second condition, participants performed the same motor task while concurrently performing a cognitive task consisting in a complex visual search combined with counting. In the dual-task condition, we found a significant increase in the duration of the preload phase (time between initial contact of the fingers with the apparatus and onset of the load force), as well as a significant increase of the grip force during the holding phase, indicating that the cognitive task interfered with the initial force scaling performed during the preload phase and the fine-tuning of grip force during the hold phase. These findings indicate that these aspects of precision grip require cognitive resources. In contrast, other aspects of the precision grip, such as the temporal coupling between grip and load forces, were not affected by the cognitive task, suggesting that they reflect more automatic processes. Taken together, our results suggest that assessing the dynamic and temporal parameters of precision grip in the context of a concurrent cognitive task may constitute a more ecological and better-suited tool to characterize motor dysfunction in patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Cognitive-Motor Interference While Grasping, Lifting and Holding Objects

2013

View full text Add to dashboard Cite

show abstract

“…Three ROIs were defined anatomically as follows: the M1 as the area extending from the anterior bank of the central sulcus to the anterior edge of the precentral gyrus (Dassonville et al, 2001; Kimberley et al, 2008b,c), the PMC as the area between M1 and the sulcus nearest the coronal plane through the anterior commissure, bounded inferiorly by the inferior edge of the frontal lobe (Dassonville et al, 2001), and the SMA as the medial region of the hemispheres superior to the dorsal bank of the cingulated sulcus along the same anterior-posterior extent as the PM (Dassonville et al, 2001; Kimberley et al, 2008a,c). …”

Section: Methodsmentioning

confidence: 99%

Oscillatory motor network activity during rest and movement: an fNIRS study

Bajaj

Drake

Butler

et al. 2014

Front. Syst. Neurosci.

View full text Add to dashboard Cite

Coherent network oscillations (<0.1 Hz) linking distributed brain regions are commonly observed in the brain during both rest and task conditions. What oscillatory network exists and how network oscillations change in connectivity strength, frequency and direction when going from rest to explicit task are topics of recent inquiry. Here, we study network oscillations within the sensorimotor regions of able-bodied individuals using hemodynamic activity as measured by functional near-infrared spectroscopy (fNIRS). Using spectral interdependency methods, we examined how the supplementary motor area (SMA), the left premotor cortex (LPMC) and the left primary motor cortex (LM1) are bound as a network during extended resting state (RS) and between-tasks resting state (btRS), and how the activity of the network changes as participants execute left, right, and bilateral hand (LH, RH, and BH) finger movements. We found: (i) power, coherence and Granger causality (GC) spectra had significant peaks within the frequency band (0.01–0.04 Hz) during RS whereas the peaks shifted to a bit higher frequency range (0.04–0.08 Hz) during btRS and finger movement tasks, (ii) there was significant bidirectional connectivity between all the nodes during RS and unidirectional connectivity from the LM1 to SMA and LM1 to LPMC during btRS, and (iii) the connections from SMA to LM1 and from LPMC to LM1 were significantly modulated in LH, RH, and BH finger movements relative to btRS. The unidirectional connectivity from SMA to LM1 just before the actual task changed to the bidirectional connectivity during LH and BH finger movement. The uni-directionality could be associated with movement suppression and the bi-directionality with preparation, sensorimotor update and controlled execution. These results underscore that fNIRS is an effective tool for monitoring spectral signatures of brain activity, which may serve as an important precursor before monitoring the recovery progress following brain injury.

show abstract

“…In bimanual movements, the interaction of the ipsilesional SMA and the contralesional motor cortex was reduced, and this correlated with impaired bimanual performance. This can be related to the observation that there was less activation in contralesional motor cortex when the motor task did not require working memory demands and no change when the task required online visual feedback monitoring ( 153 ). Furthermore, connectivity strength of the prefrontal cortex to the premotor cortex was enhanced in relation to motor imagery highlighting its role for higher order planning of movement ( 154 ).…”

Section: Mechanisms Of Post-stroke Recoverymentioning

confidence: 99%

Recovery Potential After Acute Stroke

Seitz

Donnan

2015

Front. Neurol.

View full text Add to dashboard Cite

In acute stroke, the major factor for recovery is the early use of thrombolysis aimed at arterial recanalization and reperfusion of ischemic brain tissue. Subsequently, neurorehabilitative training critically improves clinical recovery due to augmention of postlesional plasticity. Neuroimaging and electrophysiology studies have revealed that the location and volume of the stroke lesion, the affection of nerve fiber tracts, as well as functional and structural changes in the perilesional tissue and in large-scale bihemispheric networks are relevant biomarkers of post-stroke recovery. However, associated disorders, such as mood disorders, epilepsy, and neurodegenerative diseases, may induce secondary cerebral changes or aggravate the functional deficits and, thereby, compromise the potential for recovery.

show abstract

Neural Substrates of Cognitive Load Changes During a Motor Task in Subjects with Stroke

Cited by 10 publications

References 47 publications

Cognitive-Motor Interference While Grasping, Lifting and Holding Objects

Cognitive-Motor Interference While Grasping, Lifting and Holding Objects

Oscillatory motor network activity during rest and movement: an fNIRS study

Recovery Potential After Acute Stroke

Contact Info

Product

Resources

About