Neural Tube Defects in Southwestern Region of Saudi Arabia

El-Awad, Mohamad El-Hag; Sivasankaran, Subramaniam

doi:10.5144/0256-4947.1992.449

Cited by 15 publications

(9 citation statements)

References 15 publications

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“…10 Other countries have intermediate rates of incidence. Anencephaly occurs six times more in whites than in blacks 1,2,7,8,10 and females are more often affected than males, as was seen in our study.…”

Section: Discussionsupporting

confidence: 74%

“…1,2,4,7 In a previous study on infants in the Asir Region during the period December 1987-December 1990, El-Awad et al 8 found the overall incidence of NTD to be 0.82/1000 births, which indicates that the frequency of the disease in the region has remained virtually the same since the 1980s. DH=dislocation of the hip; AH=adrenal hyperplasia; *the patient with meningocele had no associated anomaly and the 3 patients with anencephaly were not screened for associated lesions.…”

Section: Discussionmentioning

confidence: 99%

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Neural Tube Defects in the Asir Region of Saudi Arabia

Asindi

Alshehri

2001

Annals of Saudi Medicine

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Neural Tube Defects in the Asir Region of Saudi Arabia

Asindi

Alshehri

2001

Annals of Saudi Medicine

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“…In the West, antenatal screening coupled with selective termination have much reduced antenatal hydrocephalus. With the great improvement of socioeconomic conditions and the care of expectant mothers, it is expected that there would be a further reduction in the incidence of this problem 6. The administration of Periconceptional folic acid should reduce this incidence still further.…”

Section: Discussionmentioning

confidence: 99%

Infantile hydrocephalus in the south-western region of Saudi Arabia

Awad

1992

Annals of Tropical Paediatrics

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During the period January 1988 to December 1990, the overall incidence of infantile hydrocephalus in the south-western region of Saudi Arabia was 0.81/1000. The series comprised 61 infants affected by infantile hydrocephalus. The total number of live births in this period was 74,923. Hydrocephalus associated with spinal dysraphism (spina bifida cystica and encephalocoele) constituted 24 cases (39.3%), and there was aqueduct stenosis in 10 cases (16.4%). Nine cases (11.9%) were post-meningitic, and seven (14.8%) post-haemorrhagic. There was Dandy-Walker malformation in five cases (8.2%), three (4.9%) had congenital idiopathic hydrocephalus, two (3.3%) congenital toxoplasmosis, and one (1.6%) isolated Arnold Chiari malformation. There were congenital causes in 45 cases, 73.7% of all the cases in this series (incidence: 0.6/1000 births). Of the remaining 16 cases (26.3%) which were due to postnatal factors, seven (11.5%) were caused by acquired cerebral haemorrhage, only two of them being premature, and the other nine (14.8%) were due to meningitis. The data indicate the predominance of prenatal causes of infantile hydrocephalus and the relatively low contribution of extreme prematurity. This is possibly due to the high mortality of this group of infants in this region.

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“…Year Province Incidence (per 1000 live births) Prevalence (per 1000 live births) Magbool et al, 4 1989 Eastern province 1.83 --El-Awad et al, 5 1992 Southern province 0.82 --Asindi et al, 6 2001 0.78 --Safdar et al, 7 2007 Western province 0.76 --Seidahmed et al, 2014…”

Section: Studymentioning

confidence: 99%

“…4 Saudi health authorities adopted folic acid supplementation, one of the most effective preventives for MMC, for pregnant women decades ago, taking into consideration the appropriate dose and timing of folic acid before conception or even initiating folic acid supplementation among all married women to reduce the burden of unplanned pregnancy. 5 However, only 9.7% of pregnant Saudi women used folic acid supplementation before conception with continuation throughout pregnancy, which is far below the expectation for such an ambitious plan. 6 Other studies have reported that approximately 4% of Saudi women use folic acid during pregnancy, 8.3% of whom have had previous children with congenital anomalies.…”

mentioning

confidence: 98%

Review on myelomeningocele management and its current status in Saudi Arabia

Alnaami

Alayad

2019

NSJ

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Major approaches have emerged in the field of myelomeningocele (MMC) management. The prevalence of MMC in Kingdom of Saudi Arabia is 0.44-1.46/1000 births. Nine point seven percent of pregnant Saudi women take folic acid before conception; MMC is estimated to result in 1,417,500 Saudi Riyals (SAR) in lifetime costs per patient. Abortion should be performed cautiously in Muslim countries; another option may be the intrauterine foetal surgical repair of MMC, which has better neuromotor outcomes and reduces the need for ventriculoperitoneal shunt, albeit with a higher risk of obstetric complications. Seven years after intrauterine foetal surgery emerged, there is a need to establish this service in Kingdom of Saudi Arabia. A multidisciplinary approach is required for MMC Review Article patients; surgical closure should be carried out within 72 hours after birth to reduce the risk of infection. Advancing MMC care allows patients to survive to adulthood, and action must be taken to improve the quality of MMC care in Kingdom of Saudi Arabia.

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Neural Tube Defects in Southwestern Region of Saudi Arabia

Cited by 15 publications

References 15 publications

Neural Tube Defects in the Asir Region of Saudi Arabia

Neural Tube Defects in the Asir Region of Saudi Arabia

Infantile hydrocephalus in the south-western region of Saudi Arabia

Review on myelomeningocele management and its current status in Saudi Arabia

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