Neurasthenic fatigue, chemical sensitivity and GABAa receptor toxins

Corrigan, Frank M.; Macdonald, Shiona; Brown, Adam R.; Armstrong, Kelly; Armstrong, E.M.

doi:10.1016/0306-9877(94)90065-5

Cited by 27 publications

(15 citation statements)

References 17 publications

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“…Accordingly, quite apart from the mechanisms considered above, it is to be expected that substantial changes in cholinergic function induced by OPs will have widespread effects on other neurotransmitter systems, and the possibility that this may represent another mechanism whereby OPs adversely effect mental health has been raised by Corrigan et al [44].…”

Section: Discussionmentioning

confidence: 98%

Organophosphates, Affective Disorders and Suicide

Vies¹

1995

Journal of Nutritional & Environmental Medicine

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Evidence to associate exposure to organophosphate (OP) pesticides with the development of affective disorders and suicidal behaviour is reviewed. It is concluded on the basis of neurotoxicological studies, clinical reports and experience, and epidemiological work that such a relationship does exist and that chronic exposure to OP pesticides not only confers increased vulnerability to affective disorder and suicide but also directly induces mood destabilization in individuals otherwise at low risk of these disorders. It is recommended that a moratorium on the use of OP insecticides be declared until definitive research to establish the riskhenefit balance with regard to affective disorders, suicide and the broader range of reported adverse effects on health is completed. Gorman JM, Liebowitz MR, Fyer AJ et al. An open trial of fluoxetine in the treatment of panic attacks. J Clin Psychopharmacol 1987; 7: 329-32. J Nutr Environ Med Downloaded from informahealthcare.com by University of Otago on 01/04/15 For personal use only.

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Section: Discussionmentioning

confidence: 98%

Organophosphates, Affective Disorders and Suicide

Vies¹

1995

Journal of Nutritional & Environmental Medicine

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“…The decreased expression of Bcl-2 in the hippocampus can result in neuron apoptosis [30], which causes neuronal dysfunction in the hippocamus. Previous studies have displayed that hippocampal dysfunction is linked to neurasthenic fatigue [31], disordered sleep [32], and abnormal cognition [33], which are the main symptoms of CFS. Here, we did not observe disordered sleep and abnormal cognition; however, we found that running activity in our model mice was reduced along with Bcl-2 mRNA expression in the hippocampus.…”

Section: Discussionmentioning

confidence: 99%

Brain Atrophy in a Murine Model of Chronic Fatigue Syndrome and Beneficial Effect of Hochu-ekki-to (TJ-41)

et al. 2008

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Brain-derived neurotrophic factor (BDNF) is associated with the main symptoms of chronic fatigue syndrome (CFS) and neuron apoptosis. Nevertheless, no study has been performed directly to explore the relationship between CFS, BDNF and neuron apoptosis. We induced a CFS model by six injections of killed Brucella abortus antigen in BALB/c mice and treated them with Hochu-ekki-to (TJ-41). Daily running activity, body weight (BW), ratio of cerebral weight to BW (CW/BW) and expression levels of BDNF and Bcl-2 mRNA in the hippocampus were determined. The daily activity and CW/BW decreased significantly in the CFS model. BDNF and Bcl-2 mRNA expression levels in the hippocampus were suppressed in the CFS model and TJ-41 treated mice, while no significant difference was found between them. We improved a murine model to investigate the relationship between CFS and brain dysfunction. In this model, reduced daily activity might have been associated with decreased hippocampal BDNF mRNA expression, hippocampal apoptosis and brain atrophy. TJ-41 increased the daily running activity of the model, which was independent of brain recovery.

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Section: Individual Ids Descriptionsmentioning

confidence: 99%

“…Some (4,75,113) may be initiators of kindling (4). This interference may also extend to polychlorinated biphenyls (PCBs) (75) and in general to organophosphate (OP) and organochlorine compounds (113). Some organochlorine insecticides such as chlorpyrifos reportedly cause both chronic neurologic symptoms (114) and modulation of the IRA (112).…”

Section: Individual Ids Descriptionsmentioning

confidence: 99%