2011
DOI: 10.1186/1471-2202-12-103
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Neuregulin1/ErbB4-induced migration in ST14A striatal progenitors: calcium-dependent mechanisms and modulation by NMDA receptor activation

Abstract: BackgroundA number of studies have separately shown that the neuregulin1 (NRG1)/ErbB4 system and NMDA-type glutamate receptors (NMDARs) are involved in several aspects of neuronal migration. In addition, intracellular calcium fluctuations play central roles in neuronal motility. Stable expression of the tyrosine kinase receptor ErbB4 promotes migratory activity in the neural progenitor cell line ST14A upon NRG1 stimulation. In this work we analyzed the potential interactions between the NRG1/ErbB4 system and N… Show more

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Cited by 11 publications
(14 citation statements)
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“…To evaluate the gene expression of NMDA receptor subunits NR2A and NR2B from tissue samples corresponding to the IC (punch from AP coordinate +1.5 to − 1.5 mm), reverse transcription polymerase chain reaction (RT‐PCR) was performed. Forward and reverse primers for each subunit ( NR2A ‐ Forward: 5′‐TTCATCTGGGAGCACCTCTT‐3′; Reverse: 5′‐GGCCACAAATGTTTGGAGTT‐3′/ NR2B ‐ Forward: 5′‐GGCATTGCTATCCAAAAGGA‐3′; Reverse: 5′‐GACAGGTTGGCCATGTTCTT‐3′), as previously described . An electrophoresis was conducted for visualization of the bands corresponding to the gene expression of NR2A and NR2B subunits in a 1% agarose gel.…”
Section: Methodsmentioning
confidence: 99%
“…To evaluate the gene expression of NMDA receptor subunits NR2A and NR2B from tissue samples corresponding to the IC (punch from AP coordinate +1.5 to − 1.5 mm), reverse transcription polymerase chain reaction (RT‐PCR) was performed. Forward and reverse primers for each subunit ( NR2A ‐ Forward: 5′‐TTCATCTGGGAGCACCTCTT‐3′; Reverse: 5′‐GGCCACAAATGTTTGGAGTT‐3′/ NR2B ‐ Forward: 5′‐GGCATTGCTATCCAAAAGGA‐3′; Reverse: 5′‐GACAGGTTGGCCATGTTCTT‐3′), as previously described . An electrophoresis was conducted for visualization of the bands corresponding to the gene expression of NR2A and NR2B subunits in a 1% agarose gel.…”
Section: Methodsmentioning
confidence: 99%
“…Among various extrinsic factors, purinergic agonists [157,158], growth factors [159], and chemokines [160162] are well-known modulators of NSC migration. For example, ATP regulates the migration of intermediate neuronal progenitors from the ventricular zone to the subventricular zone by acting through the purinergic P2Y1 receptor [157].…”
Section: Physiological Roles Of Ca2+ Signaling In Neural Developmentmentioning
confidence: 99%
“…NRG1/ErbB4 signaling is involved in tangential migration of olfactory bulb interneuron precursors in the rostral migratory stream [165] and in migration of cortical interneuron precursors from the ventral telencephalon [166]. Mechanistically, NRG1 stimulation of ErbB4 results in a sustained [Ca 2+ ] increase in neural progenitors which involves store-operated calcium entry [159]. NRG1-induced migration is dependent on Ca 2+ influx and is positively regulated by NMDAR activation [159].…”
Section: Physiological Roles Of Ca2+ Signaling In Neural Developmentmentioning
confidence: 99%
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“…In ST14A cells, an immortalized line obtained from rat striatal primordia, Pregno et al [60] investigated the migratory activity induced by Neuregulin1 and its calcium dependence. Chelating intracellular calcium with BAPTA-AM strongly reduced cell motility; Neuregulin1 induced long lasting increases in [Ca 2+ ] i that were dependent on release from intracellular stores and ensuing activation of SOCE, as assessed in experiments with 100 µM thapsigargin, an inhibitor of calcium pumps of the endoplasmic reticulum plasmamembrane that causes the emptying of these stores.…”
Section: Calcium Release From Intracellular Storesmentioning
confidence: 99%