Neuro-Immune Regulation in Inflammation and Airway Remodeling of Allergic Asthma

Zhang, Ning; Xu, Jing; Jiang, Congshan; Lu, Shemin

doi:10.3389/fimmu.2022.894047

Cited by 13 publications

(8 citation statements)

References 119 publications

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“…With the detachment of epithelial cells and the destruction of cell junctions, allergens may stimulate the cells directly as well as deteriorating asthma further. Moreover, the proteins constituting the structure of epithelial barrier, not only act as the barriers for cells, but also participate in the activation of downstream signaling pathways as well as the amplification of inflammation 26,27 . What we concerned was the role of E‐cadherin and β‐catenin.…”

Section: Discussionmentioning

confidence: 99%

“…proteins constituting the structure of epithelial barrier, not only act as the barriers for cells, but also participate in the activation of downstream signaling pathways as well as the amplification of inflammation. 26,27 What we concerned was the role of E-cadherin and β-catenin. The first protein tends to enter the nucleus of cells after the injury, activates nuclear factor kappa B (NF-κB) and stimulates inflammatory transcription factors, resulting in the aggravation of airway inflammation; [28][29][30] as an upstream signaling molecule, the other Patients with rheumatoid arthritis had similar high levels of S100A4 in both plasma and synovial fluid, and had extracellular oligomeric S100A4 enhancement.…”

Section: Discussionmentioning

confidence: 99%

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Secreted S100A4 causes asthmatic airway epithelial barrier dysfunction induced by house dust mite extracts via activating VEGFA/VEGFR2 pathway

Huang

Zheng

et al. 2023

Environmental Toxicology

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The airway epithelial barrier dysfunction plays a crucial role in pathogenesis of asthma and causes the amplification of downstream inflammatory signal pathway. S100 calcium binding protein A4 (S100A4), which promotes metastasis, have recently been discovered as an effective inflammatory factor and elevated in bronchoalveolar lavage fluid in asthmatic mice. Vascular endothelial growth factor‐A (VEGFA), is considered as vital regulator in vascular physiological activities. Here, we explored the probably function of S100A4 and VEGFA in asthma model dealt with house dust mite (HDM) extracts. Our results showed that secreted S100A4 caused epithelial barrier dysfunction, airway inflammation and the release of T‐helper 2 cytokines through the activation of VEGFA/VEGFR2 signaling pathway, which could be partial reversed by S100A4 polyclonal antibody, niclosamide and S100A4 knockdown, representing a potential therapeutic target for airway epithelial barrier dysfunction in asthma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Secreted S100A4 causes asthmatic airway epithelial barrier dysfunction induced by house dust mite extracts via activating VEGFA/VEGFR2 pathway

Huang

Zheng

et al. 2023

Environmental Toxicology

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“…One of the medical areas most affected by these innovations is certainly childhood respiratory disorders, including asthma and cystic fibrosis (CF) (3,4). Asthma is a complex disease, mostly characterized by chronic airway inflammation and airway hyperresponsiveness and obstruction with a prominent role of T helper type 2 (Th2) cells that eventually lead to airway epithelial remodelling (5)(6)(7)(8)(9). Beyond the concept of phenotype, the last attempt to classify asthma is based on the so called endotypes, which are the different biological pathways involved in the disease.…”

Section: Biomarkers In Pediatric Lung Diseasesmentioning

confidence: 99%

New trends in pediatric pulmonology: our experience

Parisi¹,

Papale²,

Manti³

et al. 2023

Pediatr Respir J

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Until a few years ago, pediatric pulmonology was one of the most static branches of pediatrics. In recent years, the description of new pathological entities affecting the lung and airways, the identification of new disease biomarkers, the use of new respiratory function tests suitable not only for collaborating but also for non-collaborating children, the enhancement of respiratory endoscopy, the advent of new therapies such as biological drugs and genetic modulators have made pediatric pulmonology one of the most dynamic branches of pediatric medicine.The objective of this article will be to explore the new fields of pediatric pulmonology by making a parallelism with the evolutions that our center had to follow in order to adapt to the new healthcare and research standards. These same standards of care are needed by patients, their families, and need to be known by primary care pediatricians. In addition, health policy must take into account these upgrades in pediatric pulmonology to provide the best quality of care to all patients and uniformly throughout the country. CF is the most common life-shortening autosomal recessive hereditary disease in Caucasians with a prevalence of 1 case per 2500 live births. CF is a multisystem disease caused by mutations in the cystic fibrosis trans-membrane conductance regulator (CFTR) gene (11, 12). The lung is the primary site of CF, to which most of the CF-associated patient morbidity and mortality is linked. CF occurs very early in infancy and is defined by the presence of infections and chronic inflammation leading to a deterioration in lung function, respiratory exacerbations, and bronchiectasis (13,14). Thus, identifying a biomarker for disease progression might be crucial for improving these patients' outcomes. Moreover, with therapeutic introduction of potentiators and correctors of the CFTR protein, the study of biomarkers could be a valuable tool for monitoring their effectiveness over time (15). Globally, therefore, the study of biomarkers could have a strategic role in CF management and also in asthma. FRACTIONAL-EXHALED NITRIC OXIDE (FeNO)asthma treatment. Finally, CaNO is the least used in clinical practice because lack of standardization of measurement techniques. VOLATILE ORGANIC COMPOUNDS (VOCs) AND EXHALED BREATH CONDENSATE (EBC)

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“…Additionally, activation of SCCs present in the nasal epithelium might be involved in the neurogenic inflammatory pathway. The role of neuro-immune regulation in inflammation has been already the subject of research in airway inflammatory diseases, such as COPD and asthma [ 147 , 148 , 149 ].…”

Section: Other Selected Aspects Of Crs Pathogenesismentioning

confidence: 99%

Immunological Aspects of Chronic Rhinosinusitis

et al. 2022

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Chronic rhinosinusitis (CRS) is related to persistent inflammation with a dysfunctional relationship between environmental agents and the host immune system. Disturbances in the functioning of the sinus mucosa lead to common clinical symptoms. The major processes involved in the pathogenesis of CRS include airway epithelial dysfunctions that are influenced by external and host-derived factors which activate multiple immunological mechanisms. The molecular bases for CRS remain unclear, although some factors commonly correspond to the disease: bacterial, fungal and viral infections, comorbidity diseases, genetic dysfunctions, and immunodeficiency. Additionally, air pollution leads increased severity of symptoms. CRS is a heterogeneous group of sinus diseases with different clinical courses and response to treatment. Immunological pathways vary depending on the endotype or genotype of the patient. The recent knowledge expansion into mechanisms underlying the pathogenesis of CRS is leading to a steadily increasing significance of precision medicine in the treatment of CRS. The purpose of this review is to summarize the current state of knowledge regarding the immunological aspects of CRS, which are essential for ensuring more effective treatment strategies.

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Neuro-Immune Regulation in Inflammation and Airway Remodeling of Allergic Asthma

Cited by 13 publications

References 119 publications

Secreted S100A4 causes asthmatic airway epithelial barrier dysfunction induced by house dust mite extracts via activating VEGFA/VEGFR2 pathway

Secreted S100A4 causes asthmatic airway epithelial barrier dysfunction induced by house dust mite extracts via activating VEGFA/VEGFR2 pathway

New trends in pediatric pulmonology: our experience

Immunological Aspects of Chronic Rhinosinusitis

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