Neuro Interfaces: Neuro‐Nano Interfaces: Utilizing Nano‐Coatings and Nanoparticles to Enable Next‐Generation Electrophysiological Recording, Neural Stimulation, and Biochemical Modulation (Adv. Funct. Mater. 12/2018)

Young, Anthony; Cornwell, Neil; Daniele, Michael A.

doi:10.1002/adfm.201870079

Cited by 12 publications

(15 citation statements)

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“…This paved the way for the development of a wide variety of biocompatible and conductive electrode–tissue interfaces. They range from platinum alloys, which are the gold standard today, to more recent developments such as conductive polymers, carbon nanotubes, and conductive nanoparticles, for instance silver nanowires or nanocrystalline diamond . With advancements in neuroscience research, it has been understood that precise spatial and temporal control of neuronal stimulation is essential to achieve interfacing down to the single‐cell level .…”

Section: Introductionmentioning

confidence: 99%

Fabrication of a Biocompatible Liquid Crystal Graphene Oxide–Gold Nanorods Electro‐ and Photoactive Interface for Cell Stimulation

Duc

Stoddart

McArthur

et al. 2019

Adv Healthcare Materials

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For decades, electrode–tissue interfaces are pursued to establish electrical stimulation as a reliable means to control neuronal cells behavior. However, spreading of electrical currents in tissues limits its spatial precision. Thus, optical cues, such as near‐infrared (NIR) light, are explored as alternatives. Presently, NIR stimulation requires higher energy input than electrical methods despite introduction of light absorbers, e.g., gold nanoparticles. As potential solution, NIR and electrical costimulation are proposed but with limited interfaces capable of sustaining this stimulation technique. Here, a novel electroactive nanocomposite with photoactive properties in the NIR range is constructed by N‐(3‐dimethylaminopropyl)‐N′‐ethylcarbodiimide hydrochloride/N‐hydroxysulfosuccinimide sodium (EDC)/NHS conjugation of liquid crystal graphene oxide (LCGO) to protein‐coated gold nanorods (AuNR). The liquid crystal graphene oxide–gold nanorod nanocomposite (LCGO–AuNR) is fabricated into a hydrophilic electrode‐coating via drop‐casting, making it appropriate for versatile electrode–tissue interface fabrication. UV–vis spectrophotometry results demonstrate that LCGO–AuNR presents an absorbance peak at 798 nm (NIR range). Cyclic voltammetry measurements further confirm its electroactive capacitive properties. Furthermore, LCGO–AuNR coating supports cell adhesion, proliferation, and differentiation of NG108‐15 neuronal cells. This biocompatible interface is anticipated, with ideal electrical and optical properties for NIR and electrical costimulation, to enable further development of the technique for energy‐efficient and precise neuronal cell modulation.

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Section: Introductionmentioning

confidence: 99%

Fabrication of a Biocompatible Liquid Crystal Graphene Oxide–Gold Nanorods Electro‐ and Photoactive Interface for Cell Stimulation

Duc

Stoddart

McArthur

et al. 2019

Adv Healthcare Materials

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“…We are only beginning to appreciate the key factors, but that is vitally important from a tissue engineering perspective and a therapeutic perspective, for example, when considering off‐target effects of nanotopographies on implantable devices. [ 93,94 ] hNSC differentiation studies have helped to contribute to this emerging field.…”

Section: Va‐ns Arrays For Enhanced Human Neural Cell Differentiationmentioning

confidence: 99%

Vertically Aligned Nanostructured Topographies for Human Neural Stem Cell Differentiation and Neuronal Cell Interrogation

Lestrell

O'Brien

Elnathan

et al. 2021

Advanced Therapeutics

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Neurodegenerative disorders are a widespread global health concern caused by aging, disease, and trauma, for which there are limited treatment options. Stem cell therapies, tissue engineering, and nanobiotechnologies offer hope for improved therapeutic delivery approaches, as well as tissue repair and regenerative medicine interventions. The complexity of the human brain, coupled with its limited availability for research, makes human neural lineage cells and their precursor stem cells integral to the further understanding of brain functions in health, development, and disease. Engineered nanomaterials provide highly specialized microenvironments, enabling precise interrogation of the impact of external and spatial stimuli on human neural cells in vitro, greatly advancing the knowledge of human neural function. Interacting with neural cells at the nanoscale, vertically aligned nanostructured (VA‐NS) arrays can influence cell fate and aid in more efficient cell reprogramming, and lend themselves to the development of highly targeted, sensitive signal transducer platforms suitable for in vivo monitoring of neural cell health and activity. This perspective highlights the current state of stem cell nanoneurobiology, specifically focusing on interdisciplinary advances made by VA‐NS arrays to manipulate human neural stem cells in translatable research applications. Current challenges and identify are discussed underexplored and emerging future research areas.

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“…Neural interfaces provide a window for both bio‐signal recording and modulation, which could be achieved using microelectrodes as a bridge between the tissue and external device, 1,2 presenting a promising platform to diagnose or treat disease such as Parkinson's disease, hearing or visual disorder 3–5 . With the development of neural electrode towards integration and miniaturization, the electrochemical impedance would be increased dramatically, leading to a higher energy consumption and restricting its long‐term use 6 .…”

Section: Introductionmentioning

confidence: 99%

Enhanced electrochemical performance of neural electrodes based on PEDOT:PSS hydrogel

Zeng

2021

J of Applied Polymer Sci

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Poly (3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) has attracted much attention on applications of neural interfaces and other biomedical fields due to its excellent electrical performances and good biocompatibility. However, its stability still remains challenge. Here, a conductive polymer hydrogel (CPH) made from PEDOT:PSS is modified on platinum (Pt) substrate successfully through electrochemical gelation, employing copper (Cu) as the sacrificial layer. The as-prepared CPH electrode provides extensive large surface area with good adhesion after dried in the air. The uniform flower-like structure helps the electrode achieve a significantly low square impedance down to 10.09 Ω cm 2 (reduction of 54.89%) at 1 kHz, compared with that of bare Pt. It exhibits a high cathodic charge storage capacity (CSC c ) up to 82.36 mC cm À2 , about 27 and 16.18 times higher than that of bare Pt and PEDOT:PSS coating respectively. Besides, no obviously variation of CSC c occurs after 5 CV cycles in phosphate buffered saline (PBS), and superior charge injection capacity (CIC) was also observed. Such CPH material presents great potential for preparing functionalized flexible electrode, implying promising applications on neural implants and other flexible electronics.

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Neuro Interfaces: Neuro‐Nano Interfaces: Utilizing Nano‐Coatings and Nanoparticles to Enable Next‐Generation Electrophysiological Recording, Neural Stimulation, and Biochemical Modulation (Adv. Funct. Mater. 12/2018)

Cited by 12 publications

References 0 publications

Fabrication of a Biocompatible Liquid Crystal Graphene Oxide–Gold Nanorods Electro‐ and Photoactive Interface for Cell Stimulation

Fabrication of a Biocompatible Liquid Crystal Graphene Oxide–Gold Nanorods Electro‐ and Photoactive Interface for Cell Stimulation

Vertically Aligned Nanostructured Topographies for Human Neural Stem Cell Differentiation and Neuronal Cell Interrogation

Enhanced electrochemical performance of neural electrodes based on PEDOT:PSS hydrogel

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