Neurobehavioral and neuroprotector effects of caffeine in animal models

Abstract

This review aims to analyze and contrast the neurological effects associated with the use of caffeine on neurobehavior and neuroprotection in animal models. Caffeine belongs to the group of methylxanthines that exert a direct effect on adenosine receptors associated with inhibitory or excitatory G proteins, generating modification of cyclic AMP activity and intracellular calcium flow which produces alterations in the modulation system of the neurotransmitters dopamine and glutamate. The regulation of the neurotransmission systems generates protection against the inflammation of the central nervous system, by activation of the microglia and reinforcement of the blood-brain barrier. This drug will also restore cognition or prevent memory loss in Parkinson's or Alzheimer's diseases. It is important to establish new study models in other species to assess whether the behavior of the molecule is similar and to obtain other clinical applications in its behavioral and neuroprotective effects.

Effect Of Caffeine and Adrenaline on Memory and Anxiety in Male Wistar Rats

“…While many studies suggest that caffeine produces improvement in memory either in animal (Munawar, 2022;Villanueva-Garcia et al, 2020) or in human (Borota et al, 2014;Sherman et al, 2016;Hartney, 2020) models of learning and memory, other studies report that caffeine does not affect memory (Nehlig, 2010) or even its craving impairs memory (Palmer et al, 2017). Some studies reported that long-term consumption of caffeine could inhibit hippocampus-dependent learning and memory partially through inhibition of hippocampal neurogenesis (Han et al, 2007).…”

Pathophysiology of Perinatal Asphyxia in Humans and Animal Models

“…The use of animal models has significantly contributed to the understanding of perinatal asphyxia. Several studies have used animal models for the induction of fetal asphyxia, including maternal hypoxemia, infrared thermography (IRT), reduction of in uteroplacental blood flow, umbilical cord occlusion, and embolization, among others [ 46 , 47 , 48 , 51 , 92 , 147 , 148 , 149 , 150 , 151 , 152 , 153 ] ( Figure 3 and Figure 9 ). Infrared thermography (IRT) is a technique used in both veterinary and human medicine to quantify the surface temperature of the skin based on visualizations of thermographic changes [ 154 ].…”

Quantitative Structure–Neurotoxicity Assessment and In Vitro Evaluation of Neuroprotective and MAO-B Inhibitory Activities of Series N′-substituted 3-(1,3,7-trimethyl-xanthin-8-ylthio)propanehydrazides

“…Caffeine has neuroprotector and cytoprotector effects in cases of dopamine-induced damage by regulating the levels of this neurotransmitter [29]. Caffeine has also been associated with an effect that retards signs of neuronal degeneration in diseases like Parkinson's and Alzheimer's, effects that occur through interaction with adenosine receptors and a possible association with N-methyl D-aspartate receptors (NMDA), which increase cognition and delay the onset of the associated signs [35][36][37].…”